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Chapter 20 - Mature B-Cell Non-Hodgkin Neoplasms

from Section V - Mature Lymphoid Neoplasms

Published online by Cambridge University Press:  25 January 2024

By
Xiayuan Liang
Edited by
Xiayuan Liang ,
Bradford Siegele  and
Jennifer Picarsic
Xiayuan Liang
Affiliation:
Children’s Hospital of Colorado
Bradford Siegele
Affiliation:
Children’s Hospital of Colorado
Jennifer Picarsic
Affiliation:
Cincinnati Childrens Hospital Medicine Center
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Summary

Non-Hodgkin lymphomas (NHLs) of childhood and adulthood differ considerably in biology, incidence, treatment, and outcome [1]. Pediatric NHLs are nearly evenly split between B-cell and T-cell neoplasms, whereas in adults, nearly 80% of NHLs are of B-cell origin [2]. The vast majority of mature B-cell NHLs in children and adolescents are high-grade, including Burkitt lymphoma/leukemia (BL), diffuse large B-cell lymphoma (DLBCL), and other less common histologies. Extranodal disease is more common in children than in adults [2]. Pediatric-type follicular lymphoma and nodal and extranodal marginal-zone lymphoma are uncommon in the pediatric population, accounting for <10% of mature B-cell lymphomas among patients <18 years of age [1]. The current classification of mature B-cell lymphoma is reviewed comprehensively in the 2017 WHO Classification published by the World Health Organization (WHO). Some of these entities occur only in adults. The entities that can occur in pediatric patients are discussed in the following sections [2].

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Chapter
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Pediatric Pathology of Hematopoietic and Histiocytic Disorders , pp. 235 - 262
Publisher: Cambridge University Press
Print publication year: 2024

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