Skip to main content Accessibility help
×
Hostname: page-component-cd9895bd7-7cvxr Total loading time: 0 Render date: 2024-12-22T02:26:20.686Z Has data issue: false hasContentIssue false

15 - Toxoplasma gondii, Sarcocystis neurona, and Neospora caninum: the worst of the coccidians?

Published online by Cambridge University Press:  24 November 2009

Gerald Esch
Affiliation:
Wake Forest University, North Carolina
Get access

Summary

The sick are the greatest danger for the healthy; it is not from the strongest that harm comes to the strong, but from the weakest.

Genealogy of Morals, Friedrich Nietzsche (1844–1900)

Without question, the most speciose group of eukaryotic parasites are the coccidians. For me, the three most significant members are Toxoplasma gondii, Sarcocystis neurona, and Neospora caninum. One way or another, J. P. Dubey has had a direct hand, literally, in discovering and naming two of these organisms, in resolving one of the parasites' life cycle, and in developing a significantly deeper understanding regarding the biology of all three. Two of these three coccidians, namely T. gondii and N. caninum, infect more people, and cause more abortions in sheep and cattle, than any other protozoan parasite. The third, S. neurona, inflicts serious neurological damage to horses within the U.S.A. Because of the significant medical, veterinary, and economic importance of these parasites, I wanted to talk with J. P. and learn what I could about his interest in these organisms and the diseases they cause. Having known J. P. for probably thirty years, I thought I knew the answer, but I wanted to satisfy my curiosity and see if my guesswork was correct, so I headed for Beltsville, Maryland, in early May of 2006 to find out.

His ‘love affair’ for protozoan parasites, especially Toxoplasma gondii, goes back a long way.

Type
Chapter
Information
Parasites and Infectious Disease
Discovery by Serendipity and Otherwise
, pp. 328 - 344
Publisher: Cambridge University Press
Print publication year: 2007

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Bjerkas, I., Mohn, S. F., and Presthus, J.. 1984. Unidentified cyst-forming sporozoon causing encephalomyelitis and myositis in dogs. Zeitschrift fur Parasitenkunde 70: 46–54.CrossRefGoogle ScholarPubMed
Dubey, J. P.,Davis, G. E., Koestner, A., and, K. Kiryu, . 1974. Equine encephalomyelitis due to a protozoan parasite resembling Toxoplasma gondii. Journal of the American Veterinary Medicine Association 165: 249–255.Google ScholarPubMed
Dubey, J. P., Hattel, A. L., Lindsay, D. S., and Topper, M. J.. 1988. Neonatal Neospora caninum infection in dogs: isolation of the causative agent and experimental transmission. Journal of the American Veterinary Association 193: 1259–1263.Google ScholarPubMed
Dubey, J. P., Davis, S. W., Speer, C. A.et al., 1991. Sarcocystis neurona n. sp. (Protozoa: Apicomplexa), the causative agent of equine protozoal myeloencephalitis. Journal of Parasitology 77: 212–218.CrossRefGoogle Scholar
Fenger, C. K., Granstrom, D. E., Langemeir, J. L.et al. 1996. Identification of opposums (Didelphis virginianus) as the putative definitive host of Sarcocystis neurona. Journal of Parasitology 81: 916–919.CrossRefGoogle Scholar
Frenkel, J. K., Dubey, J. P., and Miller, N. L.. 1970. Toxoplasma gondii in cats: fecal stages identified as coccidian cysts. Science 167: 893–896.CrossRefGoogle Scholar
Hutchison, W. M. 1965. Experimental transmission of Toxoplasma gondii. Nature 206: 961–962.CrossRefGoogle ScholarPubMed
Thilsted, J. P. and Dubey, J. P.. 1989. Neosporosis-like abortions in a herd of dairy cattle. Journal of Veterinary Diagnostic Investigations 1: 205–209.CrossRefGoogle Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×