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3 - Local Anesthetics

from PART I - LOCOREGIONAL PAIN CONTROL

Published online by Cambridge University Press:  04 September 2009

Charles E. Ray, Jr.
Affiliation:
Denver Health Medical Center
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Summary

HISTORY

Ruetsch et al. provide an in-depth review of the history of local anesthesia in their 2001 paper titled “From Rocaine to Ropivacaine: The History of Local Anesthetic Drugs” (1). What follows is a summary of pertinent points in their eloquent historical review.

Cocaine has its linguistic origin in a Peruvian plant, revered by the natives for its stimulating properties. The word Khoka, meaning the plant,” evolved into the European coca over time. We owe the term cocaine to Albert Niemann who isolated the main alkaloid from the coca leaves. A Viennese pharmacologist, Karl Damian Ritter von Schroff, described coca-induced skin insensibility. Samuel Percy was “the first to propose the use of the coca leaves as an anesthetic” in 1856. Carl Koller, in 1884, first used cocaine for ophthalmological anesthesia at the suggestion of Sigmund Freud. Addictive properties of cocaine were soon discovered as well, and many practitioners became affected, Freud and William Halsted among them. The dependency placed a significant damper on the availability of local anesthesia for medical procedures.

Subsequent pharmacological advances have led to the development of several local anesthetic compounds in the late 19th and throughout most of the 20th centuries. The delivery of local anesthetics would not have been possible, were it not for the invention, in 1844, of a hollow hypodermic needle and syringe by an Irishman, Francis Rynd (2).

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Publisher: Cambridge University Press
Print publication year: 2008

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References

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