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Chapter 12 - Premature Ovarian Insufficiency

Published online by Cambridge University Press:  28 January 2023

By
Lina Michala
Edited by
Naomi S. Crouch  and
Cara E. Williams
Naomi S. Crouch
Affiliation:
St Michael's Hospital, Bristol
Cara E. Williams
Affiliation:
Liverpool Women's Hospital
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Summary

Premature Ovarian Insufficiency (POI) is defined by follicular depletion that occurs under the age of 40 and is characterised by a gradual fall of hormone production by the ovary, leading to amenorrhoea and infertility. The hallmark for diagnosis is raised follicular stimulating hormone (FSH) above 25 IU/L measured twice, at least 4 weeks apart.

Type
Chapter
Information
Paediatric and Adolescent Gynaecology for the MRCOG , pp. 94 - 98
Publisher: Cambridge University Press
Print publication year: 2023

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References

Kelsey, TW, Wright, P, Nelson, SM, Anderson, RA, Wallace, WH. A validated model of serum anti-Müllerian hormone from conception to menopause. PLoS One. 2011;6(7):e22024.Google Scholar
Raspa, M, Wheeler, AC, Riley, C. Public health literature review of fragile X syndrome. Pediatrics. 2017;139(Suppl 3):S153–71.Google Scholar
Fridovich-Keil, JL, Gubbels, CS, Spencer, JB, Sanders, RD, Land, JA, Rubio-Gozalbo, E. Ovarian function in girls and women with GALT-deficiency galactosemia. J Inherit Metab Dis. 2011;34(2):357–66.Google Scholar
Nuovo, S, Passeri, M, Di Benedetto, E, Calanchini, M, Meldolesi, I, Di Giacomo, MC, et al. Characterization of endocrine features and genotype-phenotypes correlations in blepharophimosis-ptosis-epicanthus inversus syndrome type 1. J Endocrinol Invest. 2016;39(2):227–33.Google Scholar
Tapanainen, JS, Vaskivuo, T, Aittomäki, K, Huhtaniemi, IT. Inactivating FSH receptor mutations and gonadal dysfunction. Mol Cell Endocrinol. 1998;145(1–2):129–35.Google Scholar
Bakalov, VK, Vanderhoof, VH, Bondy, CA, Nelson, LM. Adrenal antibodies detect asymptomatic auto-immune adrenal insufficiency in young women with spontaneous premature ovarian failure. Hum Reprod. 2002;17(8):2096–100.Google Scholar
SIGN. Long term follow up of survivors of childhood cancer. Edinburgh: SIGN; 2013.Google Scholar
ESHRE Guideline: Management of women with premature ovarian insufficiency. Guideline of the European Society of Human Reproduction and Embryology. Hum Reprod. 2016;31(5):926–37.Google Scholar
Crofton, PM, Evans, N, Bath, LE, Warner, P, Whitehead, TJ, Critchley, HO, et al. Physiological versus standard sex steroid replacement in young women with premature ovarian failure: effects on bone mass acquisition and turnover. Clin Endocrinol (Oxf). 2010;73(6):707–14.Google Scholar
Popat, VB, Calis, KA, Vanderhoof, VH, Cizza, G, Reynolds, JC, Sebring, N, et al. Bone mineral density in estrogen-deficient young women. J Clin Endocrinol Metab. 2009;94(7):2277–83.Google Scholar
van der Schouw, YT, van der Graaf, Y, Steyerberg, EW, Eijkemans, JC, Banga, JD. Age at menopause as a risk factor for cardiovascular mortality. Lancet. 1996;347(9003):714–8.Google Scholar
Epperson, CN, Amin, Z, Ruparel, K, Gur, R, Loughead, J. Interactive effects of estrogen and serotonin on brain activation during working memory and affective processing in menopausal women. Psychoneuroendocrinology. 2012;37(3):372–82.Google Scholar
Guerrieri, GM, Martinez, PE, Klug, SP, Haq, NA, Vanderhoof, VH, Koziol, DE, et al. Effects of physiologic testosterone therapy on quality of life, self-esteem, and mood in women with primary ovarian insufficiency. Menopause. 2014;21(9):952–61.Google Scholar
Hadnott, TN, Gould, HN, Gharib, AM, Bondy, CA. Outcomes of spontaneous and assisted pregnancies in Turner syndrome: the US National Institutes of Health experience. Fertil Steril. 2011;95(7):2251–6.Google Scholar
van Dalen, EC, van der Pal, HJ, van den Bos, C, Kok, WE, Caron, HN, Kremer, LC. Clinical heart failure during pregnancy and delivery in a cohort of female childhood cancer survivors treated with anthracyclines. Eur J Cancer. 2006;42(15):2549–53.Google Scholar

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