Skip to main content Accessibility help
×
Hostname: page-component-cd9895bd7-hc48f Total loading time: 0 Render date: 2024-12-22T04:15:04.147Z Has data issue: false hasContentIssue false

Chapter 11 - Differences in Sex Development

Published online by Cambridge University Press:  28 January 2023

Naomi S. Crouch
Affiliation:
St Michael's Hospital, Bristol
Cara E. Williams
Affiliation:
Liverpool Women's Hospital
Get access

Summary

Differences in Sex Development (DSD) is an umbrella term which covers conditions arising from a difference in observed and expected sex development. This could include karyotype, gonadal tissue, or genital appearance. Previously alternative terms were used, such as intersex, pseudo-hermaphrodite and testicular feminisation, but these were inaccurate and generally disliked by patients. A consensus was reached in 2006 to change the terminology to disorders of sex development, with individual conditions referred to by their genetic basis [1]. This has been largely accepted in the medical literature, with older more pejorative terms falling from use. Whilst more accurate, the term DSD has not been without its critics, and there is a move towards describing this group of conditions as differences in sex development, which would seem to fit more appropriately with the increased understanding in anatomical variance in those with no known medical condition.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2023

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Lee, PA, Houk, CP, Ahmed, SF, Hughes, IA. Consensus statement on management of intersex disorders. Chicago Pediatr. 2006;118(2):e488500.Google Scholar
Ahmed, SF, Achermann, JC, Arlt, W, Balen, A, Conway, G, Edwards, Z, et al. Society for Endocrinology UK guidance on the initial evaluation of an infant or an adolescent with a suspected disorder of sex development (revised 2015). Clin Endocrinol (Oxf). 2016;84(5):771–88.Google Scholar
Cools, M, Nordenström, A, Robeva, R, Hall, J, Westerveld, P, Flück, C, et al. Caring for individuals with a difference of sex development (DSD): a consensus statement. Nat Rev Endocrinol. 2018;14(7):415–29.CrossRefGoogle ScholarPubMed
Once a dark secret. BMJ. 1994;308:542.Google Scholar
Roll, MF, Kneppo, C, Roth, H, Bettendorf, M, Waag, KL, Holland-Cunz, S. Feminising genitoplasty: one-stage genital reconstruction in congenital adrenal hyperplasia: 30 years’ experience. Eur J Pediatr Surg. 2006;16(5):329–33.CrossRefGoogle ScholarPubMed
Crouch, NS, Liao, LM, Woodhouse, CR, Conway, GS, Creighton, SM. Sexual function and genital sensitivity following feminizing genitoplasty for congenital adrenal hyperplasia. J Urol. 2008;179(2):634–8.CrossRefGoogle ScholarPubMed
Minto, CL, Liao, KL, Conway, GS, Creighton, SM. Sexual function in women with complete androgen insensitivity syndrome. Fertil Steril. 2003;80(1):157–64.CrossRefGoogle ScholarPubMed
Chaudhry, S, Tadokoro-Cuccaro, R, Hannema, SE, Acerini, CL, Hughes, IA. Frequency of gonadal tumours in complete androgen insensitivity syndrome (CAIS): a retrospective case-series analysis. J Pediatr Urol. 2017;13(5):498.CrossRefGoogle Scholar
Deans, R, Creighton, SM, Liao, LM, Conway, GS. Timing of gonadectomy in adult women with complete androgen insensitivity syndrome (CAIS): patient preferences and clinical evidence. Clin Endocrinol (Oxf). 2012;76(6):894–8.Google Scholar
Liao, LM, Tacconelli, E, Wood, D, Conway, G, Creighton, SM. Adolescent girls with disorders of sex development: a needs analysis of transitional care. J Pediatr Urol. 2010;6(6):609–13.CrossRefGoogle ScholarPubMed
Ismail-Pratt, IS, Bikoo, M, Liao, LM, Conway, GS, Creighton, SM. Normalization of the vagina by dilator treatment alone in complete androgen insensitivity syndrome and Mayer–Rokitansky–Kuster–Hauser syndrome. Hum Reprod. 2007;22(7):2020–4.Google Scholar
Routh, JC, Laufer, MR, Cannon, GM Jr, Diamond, DA, Gargollo, PC. Management strategies for Mayer–Rokitansky–Kuster–Hauser related vaginal agenesis: a cost-effectiveness analysis. J Urol. 2010;184(5):2116–21.Google Scholar
Crouch, NS, Creighton, SM. Transition of care for adolescents with disorders of sex development. Nat Rev Endocrinol. 2014;10(7):436–42.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×