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Chapter 14 - Chorionic gonadotropin and luteinizing hormone supplementation during ovarian stimulation

from Section 4: - Non-conventional forms used during ovarian stimulation

Published online by Cambridge University Press:  05 August 2011

By
M. Filicori ,
G.E. Cognigni ,
W. Ciampaglia ,
P. Pocognoli ,
C. Tabarelli ,
L. Parmegiani  and
A. Arnone
Edited by
Mohamed Aboulghar  and
Botros Rizk
Mohamed Aboulghar
Affiliation:
Cairo University and the IVF-ET Center
Botros Rizk
Affiliation:
University of South Alabama
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Summary

This chapter summarizes evidence related to the potential benefits and drawbacks of the use of luteinizing hormone (LH) activity in the management of anovulation and assisted reproduction therapy (ART). The specific contribution of LH and human chorionic gonadotropin (hCG) to the LH activity content of human menopausal gonadotropin (hMG) preparations is variable. Expression of the LH/CG receptor in granulosa cells is dependent upon follicle stimulating hormone (FSH) stimulation and enhanced by estrogen. In addition to FSH stimulation, proper estrogen concentration permits the achievement of optimal LH/CG receptor levels in late-follicular phase granulosa cells. Both ovulation induction (OI) and controlled ovarian stimulation (COS) are conducted with gonadotropin preparations containing FSH with or without LH activity. The administration of CG is an effective and cost-effective means to provide LH activity, as both LH and CG interact with the same gonadal receptors.

Keywords

assisted reproductionfollicle stimulating hormonegonadotropin-releasing hormoneovarian hyperstimulationoral contraceptive pillsluteinizing hormonein vitro fertilization
Type
Chapter
Information
Ovarian Stimulation , pp. 151 - 161
Publisher: Cambridge University Press
Print publication year: 2010

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