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Chapter 69 - SARS-CoV-2 Infection in Pregnancy

from Section 11 - Infectious Conditions in Pregnancy

Published online by Cambridge University Press:  23 February 2023

By
Isabelle Malhamé ,
Rohan D’Souza  and
Amira El-Messidi
Edited by
Amira El-Messidi  and
Alan D. Cameron
Amira El-Messidi
Affiliation:
McGill University, Montréal
Alan D. Cameron
Affiliation:
University of Glasgow
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Summary

A 37-year-old nulligravida with a one-year history of well-controlled essential hypertension is referred to your high-risk obstetrics clinic for preconception counseling. Recent comprehensive investigations are free of end-organ dysfunction. Maintaining a healthy lifestyle, she lost weight over the past year; her body mass index (BMI) is now 31 kg/m2. She uses condoms for contraception and is adherent to long-acting nifedipine once daily; folic acid–containing prenatal vitamins were initiated last month.

Keywords

COVID-19, SARS-CoV-2 infection, coronavirus, vaccination, pregnancyCounselingComorbiditiesPhysical examinationInvestigations, laboratory derangementsPerinatal risks, complications, maternal-fetal morbidity, adverse outcomeAntepartum, intrapartum, postpartum managementBreastfeedingVertical transmission, intrauterine transmissionTreatment, pharmacologyCOVID-19 pneumonia
Type
Chapter
Information
OSCEs in Obstetrics and Maternal-Fetal Medicine
An Evidence-Based Approach
 , pp. 877 - 886
Publisher: Cambridge University Press
Print publication year: 2023

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References

Suggested Readings

Allotey, J, Stallings, E, Bonet, M, et al. Clinical manifestations, risk factors, and maternal and perinatal outcomes of coronavirus disease 2019 in pregnancy: living systematic review and meta-analysis. BMJ. 2020;370:m3320.Google Scholar
Conde-Agudelo, A, Romero, R. SARS-CoV-2 infection during pregnancy and risk of preeclampsia: a systematic review and meta-analysis. Am J Obstet Gynecol. 2021;S0002–9378(21)00795-X.Google Scholar
Di Mascio, D, Buca, D, Berghella, V, et al. Counseling in maternal-fetal medicine: SARS-CoV-2 infection in pregnancy. Ultrasound Obstet Gynecol. 2021;57(5):687–697.Google Scholar
D’Souza, R, Ashraf, R, Rowe, H, et al. Pregnancy and COVID-19: pharmacologic considerations. Ultrasound Obstet Gynecol. 2021;57(2):195–203.CrossRefGoogle ScholarPubMed
Galang, RR, Newton, SM, Woodworth, KR, et al. Risk factors for illness severity among pregnant women with confirmed severe acute respiratory syndrome coronavirus 2 infection – surveillance for emerging threats to mothers and babies network, 22 state, local, and territorial health departments, 29 March 2020–5 March 2021. Clin Infect Dis. 2021;73(Suppl 1):S17–S23.CrossRefGoogle ScholarPubMed
Moore, KM, Suthar, MS. Comprehensive analysis of COVID-19 during pregnancy. Biochem Biophys Res Commun. 2021;538:180–186.Google Scholar
Royal College of Obstetricians and Gynaecologists. Coronavirus (COVID-19) infection in pregnancy; Version 14, August 25, 2021. Available at www.rcog.org.uk/coronavirus-pregnancy. Accessed September 25, 2021.Google Scholar
Shimabukuro, TT, Kim, SY, Myers, TR, et al. Preliminary findings of mRNA Covid-19 vaccine safety in pregnant persons. N Engl J Med. 2021;384(24):2273–2282. [Correction in N Engl J Med. 2021 Sep 8]CrossRefGoogle ScholarPubMed
(a)SMFM – Coronavirus (COVID-19) and pregnancy: what maternal-fetal medicine subspecialists need to know; November 23, 2020. Available at www.smfm.org/covidclinical. Accessed September 25, 2021.Google Scholar
SMFM – Management considerations for pregnant women with COVID-19; February 2, 2021. Available at at www.smfm.org/covidclinical. Accessed September 25, 2021.Google Scholar
SMFM – Provider considerations for engaging in COVID-19 vaccine counseling with pregnant and lactating patients; September 24, 2021. Available at https://www.smfm.org/covidclinical. Accessed September 25, 2021.Google Scholar
Wei, SQ, Bilodeau-Bertrand, M, Liu, S, et al. The impact of COVID-19 on pregnancy outcomes: a systematic review and meta-analysis. CMAJ. 2021;193(16):E540–E548.Google Scholar

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