Chapter 5 articulates recommendations for responding to orphanage trafficking as a form of child trafficking. The chapter advocates for a comprehensive multi-sector framework that focuses on both anti-trafficking and child protection mechanisms to combat orphanage trafficking using the three pillars for addressing human trafficking that are found in the Trafficking Protocol: prosecution, prevention and protection. Using this framework, the chapter recommends that countries respond to orphanage trafficking through criminalising and prosecuting orphanage trafficking as a form of child trafficking; preventing orphanage trafficking through addressing vulnerability, demand, corruption and complicity; and providing protection and assistance for child victims and survivors of orphanage trafficking focusing on identification, reintegration and access to remedies. The chapter advocates that a child-rights-based approach with a focus on prevention and protection, as opposed to just prosecution, must be at the centre of implementation of this framework.