We have brought together a stellar group of international experts who diligently describe the best current evidence and their practice of treating women 40 and over who are trying to conceive. The table of contents includes chapters on demographic trends, contemporary insights from reproductive biology, optimal patient management, and support systems using patient experience architecture. Additional chapters include best practices in nutritional and preconceptual counseling, the most successful ART protocols and strategies as well as the most recent data on egg donation using fresh and frozen oocytes. Also included are chapters addressing optimal management of each stage of pregnancy, neonatal and long-term outcomes of children, ways to optimize these outcomes, and a discussion about the ethics of reproduction and fertility treatment in the 40 plus group. Rounding this off are sections on the discussion of emerging new reproductive technologies, rethinking and redefining family planning, or “fertility planning” for the twenty-first century including the most recent data on ovarian reserve assessment.