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3 - Vascular diseases

from Section 1 - Cardiovascular and respiratory disorders

Published online by Cambridge University Press:  19 October 2009

David R. Gambling
Affiliation:
Clinical Associate Professor, (non-salaried) Department, Anesthesiology, University of California San Diego, CA USA; Staff Anesthesiologist, Sharp Mary Birch Hospital for Women
David R. Gambling
Affiliation:
University of California, San Diego
M. Joanne Douglas
Affiliation:
University of British Columbia, Vancouver
Robert S. F. McKay
Affiliation:
University of Kansas
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Summary

Introduction

Maternal vascular lesions that become apparent during pregnancy may be present before conception but only become symptomatic as a result of the physiologic changes of pregnancy. Blood vessels are weakened by an increase in blood volume and cardiac output (CO); a decrease in systemic vascular resistance (SVR); and hormonal changes. Hence, aneurysms can expand and rupture, or arteriovenous (AV) malformations can grow and, if present in the pulmonary circulation, can worsen a preexisting shunt. Some of the rare conditions described in this chapter affect blood vessels in discrete areas of the body whereas others affect all blood vessels. Often the disorders described are part of an autoimmune disease process that impacts other organ systems. Many of the vascular disorders are associated with high maternal and neonatal mortality. For example, rupture of an enlarging aneurysm can cause abrupt, catastrophic blood loss and poor peripartum outcomes. Likewise, pulmonary hypertension worsens during pregnancy and is often associated with maternal and/or neonatal death. This chapter discusses the clinical implications for the obstetric anesthesiologist of most vascular lesions seen during pregnancy. Intracranial aneurysms during pregnancy are discussed in Chapter 9.

Primary pulmonary hypertension

Primary pulmonary hypertension is a progressive disease that produces a sustained rise of at least 25 mmHg in mean pulmonary artery pressure and an increase in pulmonary resistance, in the absence of an identified pulmonary or cardiac lesion. This inevitably leads to right ventricular (RV) dilatation and RV hypertrophy progressing to RV failure and death.

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Publisher: Cambridge University Press
Print publication year: 2008

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  • Vascular diseases
    • By David R. Gambling, Clinical Associate Professor, (non-salaried) Department, Anesthesiology, University of California San Diego, CA USA; Staff Anesthesiologist, Sharp Mary Birch Hospital for Women
  • Edited by David R. Gambling, University of California, San Diego, M. Joanne Douglas, University of British Columbia, Vancouver, Robert S. F. McKay, University of Kansas
  • Book: Obstetric Anesthesia and Uncommon Disorders
  • Online publication: 19 October 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511544552.004
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  • Vascular diseases
    • By David R. Gambling, Clinical Associate Professor, (non-salaried) Department, Anesthesiology, University of California San Diego, CA USA; Staff Anesthesiologist, Sharp Mary Birch Hospital for Women
  • Edited by David R. Gambling, University of California, San Diego, M. Joanne Douglas, University of British Columbia, Vancouver, Robert S. F. McKay, University of Kansas
  • Book: Obstetric Anesthesia and Uncommon Disorders
  • Online publication: 19 October 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511544552.004
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Vascular diseases
    • By David R. Gambling, Clinical Associate Professor, (non-salaried) Department, Anesthesiology, University of California San Diego, CA USA; Staff Anesthesiologist, Sharp Mary Birch Hospital for Women
  • Edited by David R. Gambling, University of California, San Diego, M. Joanne Douglas, University of British Columbia, Vancouver, Robert S. F. McKay, University of Kansas
  • Book: Obstetric Anesthesia and Uncommon Disorders
  • Online publication: 19 October 2009
  • Chapter DOI: https://doi.org/10.1017/CBO9780511544552.004
Available formats
×