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Chapter 10 - Epigenetics

Published online by Cambridge University Press:  17 August 2023

By
Lynda Sedley
Edited by
Ted Dinan
Ted Dinan
Affiliation:
Emeritus Professor, University College Cork, Ireland
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Summary

Like microorganisms, the human subspecies can be characterised by subtle differences at the genomic and epigenomic levels. The divergence is due to epigenetic adaptations to variations in environmental conditions and dietary staples. It is evident that environments or food choices which may be essential to sustain life in one population may be toxic to another. However, the recognition of evolutionary biodiversity has been largely ignored with universal nutritional standards and fortification of dietary staples with epigenetic modulators. Because of environmental concerns, global consumption of plants as a primary food is rising; epigenetic adaptation of biological pathways and microbiomes is required to adjust for the loss of bioactive molecules previously obtained from animal-based diets. The resulting epigenetic inflexibility may lead to over- or under-compensation of biological pathways and disease.

This chapter discusses the modern interpretation of epigenetics as the complex plasticity of the epigenome and its DNA sequence, demonstrating the potential for modulation of epigenetic pathways through nutritional, microbiome and environmental modifications.

Type
Chapter
Information
Nutritional Psychiatry
A Primer for Clinicians
 , pp. 172 - 211
Publisher: Cambridge University Press
Print publication year: 2023

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  • Epigenetics
  • Edited by Ted Dinan, Emeritus Professor, University College Cork, Ireland
  • Book: Nutritional Psychiatry
  • Online publication: 17 August 2023
  • Chapter DOI: https://doi.org/10.1017/9781009299862.011
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  • Epigenetics
  • Edited by Ted Dinan, Emeritus Professor, University College Cork, Ireland
  • Book: Nutritional Psychiatry
  • Online publication: 17 August 2023
  • Chapter DOI: https://doi.org/10.1017/9781009299862.011
Available formats
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  • Epigenetics
  • Edited by Ted Dinan, Emeritus Professor, University College Cork, Ireland
  • Book: Nutritional Psychiatry
  • Online publication: 17 August 2023
  • Chapter DOI: https://doi.org/10.1017/9781009299862.011
Available formats
×