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Chapter 3 - Fortification of Food

Principles and Practice

from Section 1 - Overview

Published online by Cambridge University Press:  02 April 2019

Robert T. Means Jr
Affiliation:
East Tennessee State University
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Nutritional Anemia
Scientific Principles, Clinical Practice, and Public Health
, pp. 16 - 30
Publisher: Cambridge University Press
Print publication year: 2019

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References

Hotz, C. and Gibson, R. S. (2001). “Assessment of home-based processing methods to reduce the phytate content and phytate/zinc molar ratio of white maize (Zea mays).J Agric Food Chem 49(2): 692698.CrossRefGoogle ScholarPubMed
Hotz, C. and Gibson, R. S. (2007). “Traditional food-processing and preparation practices to enhance the bioavailability of micronutrients in plant-based diets.J Nutr 137(4): 10971100.CrossRefGoogle ScholarPubMed
Gibson, R. S. and Anderson, V. P. (2009). “A review of interventions based on dietary diversification or modification strategies with the potential to enhance intakes of total and absorbable zinc.Food Nutr Bull 30(1): S108S143.CrossRefGoogle ScholarPubMed
Thompson, B. and Amoroso, L., Eds. (2010). Combating micronutrient deficiencies: Food based approaches, The Food and Agricultural Organization of the United Nations and CAB International.Google Scholar
Bushamuka, V. N., de Pee, S., et al. (2005). “Impact of a homestead gardening program on household food security and empowerment of women in Bangladesh.Food Nutr Bull 26(1): 1725.CrossRefGoogle ScholarPubMed
Olney, D. K., Talukder, A., et al. (2009). “Assessing impact and impact pathways of a homestead food production program on household and child nutrition in Cambodia.Food Nutr Bull 30(4): 355369.CrossRefGoogle ScholarPubMed
WHO. (2017). Nutritional anemias: tools for effective prevention and control. Geneva, World Health Organization.Google Scholar
WHO and FAO. (2006). Guidelines on food fortification with micronutrients. Geneva, World Health Organization.Google Scholar
Sazawal, S., Black, R. E., et al. (2006). “Effects of routine prophylactic supplementation with iron and folic acid on admission to hospital and mortality in preschool children in a high malaria transmission setting: community-based, randomised, placebo-controlled trial.Lancet 367(9505): 133143.CrossRefGoogle Scholar
WHO and UNICEF (2006). Iron supplementation of young children in regions where malaria transmission is intense and infectious disease highly prevalent. Geneva.Google Scholar
WHO Secretariat on behalf of the participants to the Consultation (2007). “Conclusions and recommendations of the WHO Consultation on prevention and control of iron deficiency in infants and young children in malaria-endemic areas.Food Nutr Bull 28: S621627.CrossRefGoogle Scholar
Ojukwu, J. U., Okebe, J. U., et al. (2009). “Oral iron supplementation for preventing or treating anaemia among children in malaria-endemic areas.Cochrane Database Syst Rev (3): CD006589.Google ScholarPubMed
McCuskee, S, Brickley, E. B., et al. (2014). Malaria and macronutrient deficiency as correlates of anemia in young children: a systematic review of observational studies. Ann Glob Health 80(6):458–65. doi:10.1016/j.aogh.2015.01.003.Google ScholarPubMed
Pasricha, S.-R., Hayes, E., Kalumba, K., Biggs, B.-A. (2013). “Effect of daily iron supplementation on health in children aged 4–23 months: a systematic review and meta-analysis of randomised controlled trials.” Lancet Glob Health. 1(2):e77e86. doi:10.1016/s2214-109x(13)700.CrossRefGoogle ScholarPubMed
Suchdev, P. S., Leeds, I. L., et al. (2010). “Is it time to change guidelines for iron supplementation in malarial areas?J Nutr 140(4): 875876.CrossRefGoogle ScholarPubMed
Pfeiffer, W. H. and McClafferty, B. (2007). “HarvestPlus: breeding crops for better nutrition.Crop Sci 47: S88S105.CrossRefGoogle Scholar
Bouis, H. E. and Welch, R. M. (2010). “Biofortification–a sustainable agricultural strategy for reducing micronutrient malnutrition in the global south.Crop Sci 50(2): S20S32.CrossRefGoogle Scholar
Hotz, C. and McClafferty, B. (2007). “From harvest to health: Challenges for developing biofortified staple foods and determining their impact on micronutrient status.Food Nutr Bull 28(2): S271S279.CrossRefGoogle ScholarPubMed
Haas, J. D., Beard, J. L., et al. (2005). “Iron-biofortified rice improves the iron stores of nonanemic Filipino women.J Nutr 135(12): 28232830.CrossRefGoogle ScholarPubMed
Finkelstein, J. L., Mehta, S., et al. (2015). A randomized trial of iron-biofortified pearl millet in school children in India. J. Nutr. 145(7): 15761581.CrossRefGoogle ScholarPubMed
Haas, J. D., Luna, S. V. et al. (2016). “Consuming iron-biofortified beans increases iron status in Rwandan women after 128 days in a randomized controlled feeding trial.” J. Nutr.; 146:15861592.CrossRefGoogle Scholar
Wirth, J., Poletti, S., et al. (2009). “Rice endosperm iron biofortification by targeted and synergistic action of nicotianamine synthase and ferritin.Plant Biotechnol J 7(7): 631644.CrossRefGoogle ScholarPubMed
Meenakshi, J. V., Johnson, N. L., et al. (2010). “How cost-effective is biofortification in combating micronutrient malnutrition? An ex ante assessment.World Devel 38(1): 6475.CrossRefGoogle Scholar
WHO, FAO, et al. (2009). Recommendations on wheat and maize flour fortification; Meeting report: Interim consensus statement. Geneva, World Health Organization.Google Scholar
Hurrell, R., Ranum, P., et al. (2010). “Revised recommendations for iron fortification of wheat flour and an evaluation of the expected impact of current national wheat flour fortification programs.Food Nutr Bull 31(1): S7S21.CrossRefGoogle Scholar
Berry, R. J., Bailey, L., et al. (2010). “Fortification of flour with folic acid.” Food Nutr Bull 31(1 Suppl): S2235.CrossRefGoogle ScholarPubMed
Verhoef, P. (2011). “New insights on the lowest dose for mandatory folic acid fortification?” Am J Clin Nutr 93(1): 12.CrossRefGoogle ScholarPubMed
Dary, O. and Mora, J. O. (2002). “Food fortification to reduce vitamin A deficiency: International Vitamin A Consultative Group recommendations.J Nutr 132(9 Suppl): 2927S2933S.CrossRefGoogle ScholarPubMed
Klemm, R. D., West, K. P. Jr., et al. (2010). “Vitamin A fortification of wheat flour: considerations and current recommendations.Food Nutr Bull 31(1 Suppl): S4761.CrossRefGoogle ScholarPubMed
Allen, L. H., Rosenberg, I. H., et al. (2010). “Considering the case for vitamin B12 fortification of flour.” Food Nutr Bull 31(1 Suppl): S3646.CrossRefGoogle ScholarPubMed
Engle-Stone, R., Nankap, M. et al. (2017). “Iron, zinc, folate, and vitamin B-12 status increased among women and children in Yaounde and Douala, Cameroon, 1 year after introducing fortified wheat flour.J Nutr;147(7):1426–36. doi: 10.3945/jn.116.245076.CrossRefGoogle ScholarPubMed
Codex Alimentarius Commission, (1987). General Principles for the Addition of Essential Nutrients to Foods CAC/GL 09–1987 (amended 1989, 1991). Codex Alimentarius Commission Joint FAO/WHO Food Standards Programme. Rome.Google Scholar
WHO, ICCIDD, et al. (1996). Recommended iodine levels in salt and guidelines for monitoring their adequacy and effectiveness. Geneva, World Health Organization.Google Scholar
Nestel, P., Briend, A., et al. (2003). “Complementary food supplements to achieve micronutrient adequacy for infants and young children.J Pediatr Gastroenterol Nutr 36(3): 316328.CrossRefGoogle ScholarPubMed
Tondeur, W. C., Schauer, C. S., et al. (2004). “Determination of iron absorption from intrinsically labeled microencapsulated ferrous fumarate (sprinkles) in infants with different iron and hematologic status by using a dual-stable-isotope method.Am J Clin Nutr 80(5): 14361444.CrossRefGoogle ScholarPubMed
Troesch, B., Egli, I., et al. (2009). “Optimization of a phytase-containing micronutrient powder with low amounts of highly bioavailable iron for in-home fortification of complementary foods.Am J Clin Nutr 89(2): 539544.CrossRefGoogle ScholarPubMed
Zlotkin, S, Newton, S et al. (2013). Effect of iron fortification on malaria incidence in infants and young children in Ghana: a randomized trial. JAMA 310(9):938–47. doi: 10.1001/jama.2013.277129.CrossRefGoogle ScholarPubMed
Hurrell, R. F., Reddy, M. B., et al. (2000). “An evaluation of EDTA compounds for iron fortification of cereal-based foods.Br J Nutr 84(6): 903910.CrossRefGoogle ScholarPubMed
Walczyk, T., Tuntipopipat, S., et al. (2005). “Iron absorption by human subjects from different iron fortification compounds added to Thai fish sauce.Eur J Clin Nutr 59(5): 668674.CrossRefGoogle ScholarPubMed
Fritz, J. C., Pla, G. W., et al. (1974). “Collaborative study of the rat hemoglobin repletion test for bioavailability of iron.J Assoc Off Anal Chem 57(3): 513517.Google ScholarPubMed
Wegmuller, R., Zimmermann, M. B., et al. (2004). “Particle size reduction and encapsulation affect the bioavailability of ferric pyrophosphate in rats.J Nutr 134(12): 33013304.CrossRefGoogle ScholarPubMed
Hurrell, R. F. (2002). “Fortification: overcoming technical and practical barriers.J Nutr 132(4 Suppl): 806S–812S.CrossRefGoogle ScholarPubMed
Hurrell, R. and Egli, I. (2007). Optimizing the bioavailability of iron compounds for food fortification. Basel: Sight and Life Press.Google Scholar
Hurrell, R. (2010). “Use of ferrous fumarate to fortify foods for infants and young children.Nutr Rev 68(9): 522530.CrossRefGoogle ScholarPubMed
Hurrell, R. F. (2002). “How to ensure adequate iron absorption from iron-fortified food.Nutr Rev 60(7 Pt 2): S715.CrossRefGoogle ScholarPubMed
Bothwell, T. H. and MacPhail, A. P. (2004). “The potential role of NaFeEDTA as an iron fortificant.Int J Vit Nutr Res 74(6): 421434.CrossRefGoogle ScholarPubMed
Joint FAO/WHO Food Standards Programme Codex Committee on Food Additives, (2008). Matters of interest arising from FAO and WHO and from the 68th meeting of the joint FAO/WHO Expert Committee on Food Additives (JECFA). 40th Session. Beijing China: Joint FAO/WHO Food Standards Programme Codex Committee on Food Additives.Google Scholar
EFSA (2010). Scientific opinion on the use of ferric sodium EDTA as a source of iron added for nutritional purposes to foods for the general population (including food supplements) and to food for particular nutritional uses. Parma.Google Scholar
Conrad, M. E. and Schade, S. G. (1968). “Ascorbic acid chelates in iron absorption: a role for hydrochloric acid and bile.Gastroenterology 55(1): 3545.CrossRefGoogle ScholarPubMed
Lynch, S. R. and Cook, J. D. (1980). “Interaction of vitamin C and iron.Ann N Y Acad Sci 355: 3244.CrossRefGoogle ScholarPubMed
Stekel, A., Olivares, M., et al. (1986). “Absorption of fortification iron from milk formulas in infants.Am J Clin Nutr 43(6): 917922.CrossRefGoogle ScholarPubMed
Hallberg, L., Brune, M., et al. (1989). “Iron absorption in man: ascorbic acid and dose-dependent inhibition by phytate.Am J Clin Nutr 49(1): 140144.CrossRefGoogle ScholarPubMed
Siegenberg, D., Baynes, R. D., et al. (1991). “Ascorbic acid prevents the dose-dependent inhibitory effects of polyphenols and phytates on nonheme-iron absorption.Am J Clin Nutr 53(2): 537541.CrossRefGoogle ScholarPubMed
Walczyk, T., Muthayya, S. et al. (2014). “Inhibition of iron absorption by calcium is modest in an iron-fortified, casein- and whey-based drink in Indian children and is easily compensated for by addition of ascorbic acid.” J Nutr. 2014;144(11):1703–9.CrossRefGoogle Scholar
Bjorn-Rasmussen, E. and Hallberg, L. (1979). “Effect of animal proteins on the absorption of food iron in man.Nutr Metab 23(3): 192202.CrossRefGoogle ScholarPubMed
Baech, S. B., Hansen, M., et al. (2003). “Nonheme-iron absorption from a phytate-rich meal is increased by the addition of small amounts of pork meat.” Am J Clin Nutr 77(1): 173179.CrossRefGoogle ScholarPubMed
Bach Kristensen, M., Hels, O., et al. (2005). “Pork meat increases iron absorption from a 5-day fully controlled diet when compared to a vegetarian diet with similar vitamin C and phytic acid content.” Br J Nutr 94(1): 7883.CrossRefGoogle ScholarPubMed
Reddy, M. B., Hurrell, R. F., et al. (2006). “Meat consumption in a varied diet marginally influences nonheme iron absorption in normal individuals.J Nutr 136(3): 576581.CrossRefGoogle Scholar
Armah, C. N., Sharp, P., et al. (2008). “L-alpha-glycerophosphocholine contributes to meat's enhancement of nonheme iron absorption.” J Nutr 138(5): 873877.CrossRefGoogle ScholarPubMed
Hurrell, R. F., Juillerat, M. A., et al. (1992). “Soy protein, phytate, and iron-absorption in humans.Am J Clin Nutr 56(3): 573578.CrossRefGoogle ScholarPubMed
Egli, I., Davidsson, L., et al. (2003). “Phytic acid degradation in complementary foods using phytase naturally occurring in whole grain cereals.J Food Sci 68(5): 18551859.CrossRefGoogle Scholar
Sandberg, A. S., Hulthen, L. R., et al. (1996). “Dietary Aspergillus niger phytase increases iron absorption in humans.J Nutr 126(2): 476480.CrossRefGoogle ScholarPubMed
Troesch, B, H. Jing, H. et al. (2013). “Absorption studies show that phytase from Aspergillus niger significantly increases iron and zinc bioavailability from phytate-rich foods.” Food Nutr Bull, 34, S90101.CrossRefGoogle ScholarPubMed
Institute of Medicine Food and Nutrition Board (2003). Dietary Reference Intakes: applications in dietary planning. Washington, DC.Google Scholar
Hertrampf, E. (2002). “Iron fortification in the Americas.Nutr Rev 60(7 Pt 2): S2225.CrossRefGoogle ScholarPubMed
Food Fortification Initiative 2017, Global progress, Food Fortification Initiative. Available from: www.ffinetwork.org/global_progress/index.php. [17 April 2017].Google Scholar
Centers for Disease Control and Prevention (2008). “Trends in wheat-flour fortification with folic acid and iron--worldwide, 2004 and 2007.MMWR Morb Mortal Wkly Rep 57(1): 810.Google Scholar
Flour Fortification Initiative, (2004). Wheat flour fortification: Current knowledge and practical applications, Cuernavaca, Mexico.Google Scholar
Serdula, M. (2010). “The opportunity of flour fortification: building on the evidence to move forward.Food Nutr Bull 31(1 Suppl): S36.Google ScholarPubMed
Moretti, D., Biebinger, R. et al. (2014). Bioavailability of iron, zinc, folic acid, and vitamin A from fortified maize. Ann N Y Acad Sci.;1312:5465.CrossRefGoogle ScholarPubMed
WHO. (2016), WHO guideline: fortification of maize flour and corn meal with vitamins and minerals. Geneva: World Health Organization.Google Scholar
Dewey, K. G., Yang, Z. Y., et al. (2009). “Systematic review and meta-analysis of home fortification of complementary foods.Matern Child Nutr 5(4): 283321.CrossRefGoogle Scholar
Andersson, M., Theis, W., et al. (2010). “Random serial sampling to evaluate efficacy of iron fortification a randomized controlled trial of margarine fortification with ferric pyrophosphate or sodium iron edetate.” Am J Clin Nutr 92(5): 10941104.CrossRefGoogle ScholarPubMed
Glinz, , Hurrell, D. R. F. et al. (2015). “The effect of iron-fortified complementary food and intermittent preventive treatment of malaria on anaemia in 12- to 36-month-old children: a cluster-randomised controlled trial.” Malar J, 14, 347.CrossRefGoogle ScholarPubMed
Nemeth, E., Valore, E. V., et al. (2003). “Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein.Blood 101(7): 24612463.CrossRefGoogle Scholar
Rohner, F., Zimmermann, M. B., et al. (2010). “In a randomized controlled trial of iron fortification, anthelmintic treatment, and intermittent preventive treatment of malaria for anemia control in Ivorian children, only anthelmintic treatment shows modest benefit.J Nutr 140(3): 635641.CrossRefGoogle Scholar
Doherty, C. P., Cox, S. E., et al. (2008). “Iron incorporation and post-malaria anaemia.PLoS One 3(5): e2133.CrossRefGoogle ScholarPubMed
Cercamondi, C. I., Egli, I. M., et al. (2010). “Afebrile Plasmodium falciparum parasitemia decreases absorption of fortification iron but does not affect systemic iron utilization: a double stable-isotope study in young Beninese women.Am J Clin Nutr 92(6): 13851392.CrossRefGoogle Scholar
Nead, K. G., Halterman, J. S., et al. (2004). “Overweight children and adolescents: a risk group for iron deficiency.Pediatrics 114(1): 104108.CrossRefGoogle Scholar
Yanoff, L. B., Menzie, C. M., et al. (2007). “Inflammation and iron deficiency in the hypoferremia of obesity.Int J Obes (Lond) 31(9): 14121419.CrossRefGoogle ScholarPubMed
Zimmermann, M. B., Zeder, C., Muthayya, S., et al. (2008) Adiposity in women and children from transition countries predicts decreased iron absorption, iron deficiency and a reduced response to iron fortification. Int J Obes (Lond).;32(7):1098–104. doi: 10.1038/ijo.2008.43. Epub 2008 Apr 22.CrossRefGoogle Scholar
Roe, M. A., Collings, R., et al. (2009). “Plasma hepcidin concentrations significantly predict interindividual variation in iron absorption in healthy men.Am J Clin Nutr 89(4): 10881091.CrossRefGoogle ScholarPubMed
Young, M. F., Glahn, R. P., et al. (2009). “Serum hepcidin is significantly associated with iron absorption from food and supplemental sources in healthy young women.Am J Clin Nutr 89(2): 533538.CrossRefGoogle ScholarPubMed
Zimmermann, M. B., Troesch, B., et al. (2009). “Plasma hepcidin is a modest predictor of dietary iron bioavailability in humans, whereas oral iron loading, measured by stable-isotope appearance curves, increases plasma hepcidin.Am J Clin Nutr 90(5): 12801287.CrossRefGoogle ScholarPubMed
Sight and Life (2016). The #FutureFortified Global Summit on Food Fortification. Event Proceedings and recommendations for Food Fortification Programs. Basel, Switzerland: Sight and LifeGoogle Scholar
Barkley, J. S., Wheeler, K. S., et al. (2015). Anaemia prevalence may be reduced among countries that fortify flour. Br J Nutr. 114(2):265–73.CrossRefGoogle ScholarPubMed
Martorell, R, Ascencio, M. et al. (2015). Effectiveness evaluation of the food fortification program of Costa Rica: impact on anemia prevalence and hemoglobin concentrations in women and children. Am J Clin Nutr 101(1):210–7.CrossRefGoogle ScholarPubMed

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