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Chapter 1 - Parkinson’s Disease: An Overview of the Non-Motor Symptomatology

Published online by Cambridge University Press:  05 March 2022

By
Daniel van Wamelen ,
Valentina Leta  and
K. Ray Chaudhuri
Edited by
Néstor Gálvez-Jiménez ,
Amos D. Korczyn  and
Ramón Lugo-Sanchez
Néstor Gálvez-Jiménez
Affiliation:
Florida International University
Amos D. Korczyn
Affiliation:
Tel-Aviv University
Ramón Lugo-Sanchez
Affiliation:
Cleveland Clinic
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Summary

Non-motor symptoms (NMS) are a crucial component of Parkinson’s disease (PD) and the burden of the range of NMS that occurs in PD is one of the main determinants of quality of life [1]. In 1817, Dr. James Parkinson already described several NMS in his “shaking palsy,” the condition that would later be named after him, including pain, constipation, and sleep disturbances [2]. Nonetheless, after a long period of inertia, over the last 20 to 25 years, the interest in NMS has increased and evidence suggests that the overall burden of NMS dominates and can influence the risk of developing motor parkinsonism in the premotor stage of PD while being a driving factor for quality of life [3]. The identification of NMS in PD has been greatly aided by the development of specific tools, such as the NMS questionnaire (NMSQ) in 2006 [4] and the NMS Scale (NMSS) in 2007 [5].

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Non-motor Parkinson's Disease , pp. 3 - 17
Publisher: Cambridge University Press
Print publication year: 2022

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