Book contents
- Next Generation Antidepressants
- Next Generation Antidepressants
- Copyright page
- Contents
- Contributors
- Preface
- Abbreviations
- Chapter 1 Current depression landscape
- Chapter 2 Novel therapeutic targets for treating affective disorders
- Chapter 3 Developing novel animal models of depression
- Chapter 4 Translational research in mood disorders
- Chapter 5 Defining depression endophenotypes
- Chapter 6 Genetic and genomic studies of major depressive disorder
- Chapter 7 Medicinal chemistry challenges in the design of next generation antidepressants
- Chapter 8 Application of pharmacogenomics and personalized medicine for the care of depression
- Index
- References
Chapter 6 - Genetic and genomic studies of major depressive disorder
Published online by Cambridge University Press: 19 October 2021
- Next Generation Antidepressants
- Next Generation Antidepressants
- Copyright page
- Contents
- Contributors
- Preface
- Abbreviations
- Chapter 1 Current depression landscape
- Chapter 2 Novel therapeutic targets for treating affective disorders
- Chapter 3 Developing novel animal models of depression
- Chapter 4 Translational research in mood disorders
- Chapter 5 Defining depression endophenotypes
- Chapter 6 Genetic and genomic studies of major depressive disorder
- Chapter 7 Medicinal chemistry challenges in the design of next generation antidepressants
- Chapter 8 Application of pharmacogenomics and personalized medicine for the care of depression
- Index
- References
Summary
Family studies indicate that major depressive disorder runs in families, although family members’ risk for other psychiatric disorders may also be increased. Twin and adoption studies suggest that about one-third of the liability for MDD is inherited. Studies investigating individual candidate genes have failed to implicate any single gene in MDD risk. Emerging evidence from genome-wide association studies may identify novel risk genes, although any individual genetic variation appears likely to have only modest effect. Whether focusing on clinical subtypes of MDD, or relying on imaging or other biomarkers rather than clinical features, will expedite the process of gene discovery remains to be determined.
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- Next Generation AntidepressantsMoving Beyond Monoamines to Discover Novel Treatment Strategies for Mood Disorders, pp. 90 - 101Publisher: Cambridge University PressPrint publication year: 2010