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15 - Emergence of spontaneous and evoked electroencephalographic activity in the human brain

from Section 3 - Radiological and neurophysiological investigations

Published online by Cambridge University Press:  01 March 2011

By
Sampsa Vanhatalo  and
Kai Kaila
Edited by
Hugo Lagercrantz ,
M. A. Hanson ,
Laura R. Ment  and
Donald M. Peebles
Hugo Lagercrantz
Affiliation:
Karolinska Institutet, Stockholm
M. A. Hanson
Affiliation:
Southampton General Hospital
Laura R. Ment
Affiliation:
Yale University, Connecticut
Donald M. Peebles
Affiliation:
University College London
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Summary

Introduction

The adult human brain is estimated to contain about 1011 neurons with about 1000–10 000 synapses targeting each of them. This means that within each person's skull, there is a genuine microcosmos, in which the number of key elements (the ~1014 synapses) far exceeds the number of stars in our galaxy. The mere numbers above, however, provide only a faint picture of the true complexity of the brain, which is more accurately reflected in the microanatomical and functional specificity of the neuronal connections. The structural and functional specificity of wiring requires precise targeting of presynaptic endings to their proper postsynaptic locations at the subcellular level, and this has to be achieved for both local and distant connections in the course of brain development. In addition, the brain retains a high degree of structural and functional plasticity throughout an individual's lifetime, and therefore the wiring of neuronal networks is subject to control systems that maintain and also modify existing connections (Pascual-Leone et al., 2005). The plasticity of the brain is at its highest during development, and there is a massive literature describing various kinds of “sensitive” and “critical” periods during which the initial, preestablished connections show a heightened sensitivity to activity-induced modification (Katz & Crowley, 2002; Hooks & Chen, 2007).

Our genes total about 20 000 in number, and this has often been contrasted with the brain's complex phenotype to provide an argument against “genetic determinism” in brain development. However, this is not a valid comparison at all.

Type
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Information
The Newborn Brain
Neuroscience and Clinical Applications
 , pp. 229 - 244
Publisher: Cambridge University Press
Print publication year: 2010

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