Book contents
- Neuroscience for Neurosurgeons
- Neuroscience for Neurosurgeons
- Copyright page
- Contents
- Contributors
- Section 1 Basic and Computational Neuroscience
- Section 2 Clinical Neurosurgical Diseases
- Chapter 12 Glioma
- Chapter 13 Brain Metastases: Molecules to Medicine
- Chapter 14 Benign Adult Brain Tumors and Pediatric Brain Tumors
- Chapter 15 Biomechanics of the Spine
- Chapter 16 Degenerative Cervical Myelopathy
- Chapter 17 Spondylolisthesis
- Chapter 18 Radiculopathy
- Chapter 19 Spinal Tumors
- Chapter 20 Acute Spinal Cord Injury and Spinal Trauma
- Chapter 21 Traumatic Brain Injury
- Chapter 22 Vascular Neurosurgery
- Chapter 23 Pediatric Vascular Malformations
- Chapter 24 Craniofacial Neurosurgery
- Chapter 25 Hydrocephalus
- Chapter 26 Peripheral Nerve Injury Response Mechanisms
- Chapter 27 Clinical Peripheral Nerve Injury Models
- Chapter 28 The Neuroscience of Functional Neurosurgery
- Chapter 29 Neuroradiology: Focused Ultrasound in Neurosurgery
- Chapter 30 Magnetic Resonance Imaging in Neurosurgery
- Chapter 31 Brain Mapping
- Index
- References
Chapter 16 - Degenerative Cervical Myelopathy
from Section 2 - Clinical Neurosurgical Diseases
Published online by Cambridge University Press: 04 January 2024
- Neuroscience for Neurosurgeons
- Neuroscience for Neurosurgeons
- Copyright page
- Contents
- Contributors
- Section 1 Basic and Computational Neuroscience
- Section 2 Clinical Neurosurgical Diseases
- Chapter 12 Glioma
- Chapter 13 Brain Metastases: Molecules to Medicine
- Chapter 14 Benign Adult Brain Tumors and Pediatric Brain Tumors
- Chapter 15 Biomechanics of the Spine
- Chapter 16 Degenerative Cervical Myelopathy
- Chapter 17 Spondylolisthesis
- Chapter 18 Radiculopathy
- Chapter 19 Spinal Tumors
- Chapter 20 Acute Spinal Cord Injury and Spinal Trauma
- Chapter 21 Traumatic Brain Injury
- Chapter 22 Vascular Neurosurgery
- Chapter 23 Pediatric Vascular Malformations
- Chapter 24 Craniofacial Neurosurgery
- Chapter 25 Hydrocephalus
- Chapter 26 Peripheral Nerve Injury Response Mechanisms
- Chapter 27 Clinical Peripheral Nerve Injury Models
- Chapter 28 The Neuroscience of Functional Neurosurgery
- Chapter 29 Neuroradiology: Focused Ultrasound in Neurosurgery
- Chapter 30 Magnetic Resonance Imaging in Neurosurgery
- Chapter 31 Brain Mapping
- Index
- References
Summary
Degenerative cervical myelopathy(DCM) is the most debilitating form of degenerative disc disease, and is the most common acquired cause of spinal cord dysfunction in adults. DCM is caused by progressive abnormalities of the vertebral column that result in spinal cord damage due to both primary mechanical and secondary biological injury. DCM pathohistology demonstrates a consistent pattern of deleterious changes including severe Wallerian degeneration cephalad and caudal to the level of compression, apoptotic oligodendrocyte cell loss, and anterior horn dropout. Spinal cord ischemia and hypoxia play a major role in DCM pathogenesis. Novel spinal cord imaging studies such as MR spectroscopy and diffusion tensor imaging have provided novel insights into the neurobiology of this disorder. The central nervous system effects of DCM not only involve the spinal cord, but also include upstream functional and structural alterations that can influence disease progression and response to surgical intervention.
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- Information
- Neuroscience for Neurosurgeons , pp. 239 - 247Publisher: Cambridge University PressPrint publication year: 2024