Tension-type headache (TTH) is the most common form of headache in the general population. The phenotypic features of TTH are non-specific and may be seen with an assortment of secondary headache conditions, which are linked mechanistically to an identifiable structural or physiological disorder. One recent study of psychiatric comorbidity in patients with migraine, TTH, and migraine plus TTH revealed significant differences in the rate of occurrence of depression, with the combined group being of highest risk. TTH is typically managed mainly through administration of medication during acute episodes. Simple analgesics, non-steroidal anti-inflammatory drugs (NSAIDs), and combination agents are most commonly recommended. Aspirin is more effective than placebo and comparable to the efficacy of acetaminophen in the relief of acute TTH. The prognosis is generally favorable, with limited disability during headache occurrences and age-related improvement or resolution of episodes later in life.