The Diagnostic and Statistical Manual of Mental Disorders (DSM-IV-TR) classifies mood disorders as major depressive disorder, dysthymic disorder, bipolar I disorder, bipolar II disorder, and cyclothymic disorder, on the basis of the types of mood episodes present in the patient's history. The association between headaches and mood disorders has been demonstrated for many years across various cultures. Suicide is attempted more often when a patient has comorbid mood disorder and headache than when he or she has either alone. Suicidal intent is inversely correlated with quality of life. The treatment of depression is broadly divided into psychopharmacological and psychological therapies. The United States Food and Drug administration (USFDA) has approved the use of fluoxetine, sertraline, paroxetine, citalopram, escitalopram, and vilazodone for the treatment of major depressive disorder. Several treatments that are effective for mood disorders also are efficacious in headache treatment.