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Chapter 23 - New Frontiers in Neuroprognostication: Biomarkers

from Part II - Other Topics in Neuroprognostication

Published online by Cambridge University Press:  14 November 2024

By
Michael A. Pizzi  and
Katharina Busl
Edited by
David M. Greer  and
Neha S. Dangayach
David M. Greer
Affiliation:
Boston University School of Medicine and Boston Medical Center
Neha S. Dangayach
Affiliation:
Icahn School of Medicine at Mount Sinai and Mount Sinai Health System
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Summary

The use of blood and cerebrospinal fluid (CSF) biomarkers for various neurological pathologies can augment the clinician’s ability to prognosticate disease progression as well as functional and neurological outcomes. This chapter focuses on six common neurological pathologies seen in the neurological intensive care unit: secondary brain injury after cardiac arrest, intracranial hemorrhage (ICH), acute ischemic stroke, traumatic brain injury (TBI), aneurysmal subarachnoid hemorrhage (aSAH), and post-intensive care syndrome. Very few of the biomarkers have been clinically validated, but a number of biomarkers are promising in research studies and are also discussed. However, standardization of protocols and reference ranges has not been established for most biomarkers.

Type
Chapter
Information
Neuroprognostication in Critical Care , pp. 320 - 327
Publisher: Cambridge University Press
Print publication year: 2024

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