A 73-year-old-woman noticed pain in her right lower leg and thigh and left foot. After a few weeks of physiotherapy, she gradually developed tingling in her feet and a ‘plastic’ sensation in the soles of her feet. A few weeks later, her feet became completely numb, and she noticed painful tingling in her hands and around her left knee. Because of the tingling in her hands, she could barely use a fork and knife. Walking became difficult due to the dull feelings in her legs. Several drugs against painful neuropathy did not help. For years she had smoked two packs of cigarettes a week. A total of 50 pack-years was estimated.