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Case 11 - IgM Anti-MAG Polyneuropathy

from Peripheral Neuropathies

Published online by Cambridge University Press:  29 November 2024

Jessica E. Hoogendijk
Affiliation:
University Medical Center Utrecht
Marianne de Visser
Affiliation:
Amsterdam University Medical Center
Pieter A. van Doorn
Affiliation:
Erasmus MC, University Medical Center, Rotterdam
Erik H. Niks
Affiliation:
Leiden University Medical Center
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Summary

A 62-year-old man reported slowly progressive symptoms over a period of two years. He could no longer walk steadily and developed numb feelings on the soles of both feet and a tremor of both hands. He was not known to have diabetes and ate a healthy, balanced diet, drank one glass of alcohol a day, and had not been treated with neurotoxic medication.

Type
Chapter
Information
Neuromuscular Disease
A Case-Based Approach
, pp. 99 - 103
Publisher: Cambridge University Press
Print publication year: 2024

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References

Suggested Reading

Carroll, AS, Lunn, MPT. Paraproteinaemic neuropathy: MGUS and beyond. Pract Neurol 2021;21(6):492503. doi: 10.1136/practneurol-2020-002837. Epub 2021 Jul 19. PMID: 34282034.CrossRefGoogle ScholarPubMed
Chaganti, S, Hannaford, A, Vucic, S. Rituximab in chronic immune mediated neuropathies: a systematic review. Neuromuscul Disord 2022;32(8):621627. doi: 10.1016/j.nmd.2022.05.013. Epub 2022 May 24. PMID: 35672205.CrossRefGoogle ScholarPubMed
Lunn, MP, Nobile-Orazio, E. Immunotherapy for IgM anti-myelin-associated glycoprotein paraprotein-associated peripheral neuropathies. Cochrane Database Syst Rev 2016;10(10):CD002827. doi: 10.1002/14651858.CD002827.pub4. PMID: 27701752; PMCID: PMC6457998.Google ScholarPubMed
Parisi, M, Dogliotti, I, Clerico, M, et al. Efficacy of rituximab in anti-myelin-associated glycoprotein demyelinating polyneuropathy: Clinical, hematological and neurophysiological correlations during 2 years of follow-up. Eur J Neurol 2022;29(12):36113622. doi: 10.1111/ene.15553. Epub 2022 Sep 25. PMID: 36083713; PMCID: PMC9825860.CrossRefGoogle ScholarPubMed
Sommer, C, Carroll, AS, Koike, H, et al. Nerve biopsy in acquired neuropathies. J Peripher Nerv Syst 2021;26 Suppl 2:S21S41. doi: 10.1111/jns.12464. Epub 2021 Sep 14. PMID: 34523188.CrossRefGoogle ScholarPubMed
Taams, NE, Drenthen, J, Hanewinckel, R, Ikram, MA, van Doorn, PA. Prevalence and risk factor profiles for chronic axonal polyneuropathy in the general population. Neurology 2022:10.1212/WNL.0000000000201168. doi: 10.1212/WNL.0000000000201168. Epub ahead of print. PMID: 36008153.Google Scholar
Vallat, JM, Duchesne, M, Corcia, P, et al. The wide spectrum of pathophysiologic mechanisms of paraproteinemic neuropathy. Neurology 2021;96(5):214225. doi: 10.1212/WNL.0000000000011324. Epub 2020 Dec 4. PMID: 33277411.CrossRefGoogle ScholarPubMed

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