Cerebral amyloid angiopathy (CAA) is a chronic microvasculopathy caused by the misfolding of amyloid beta-peptide in the brain and deposition of the misfolded amyloid in the walls of small and medium cerebral blood vessels. Though the exact pathogenesis of the CAA is unknown, and most cases are thought to be sporadic, hereditary CAA does exist and involves the possession of the 𝛽-amyloid precursor protein (𝛽-APP) on chromosome 21, which is thought to be responsible for the misfolding of the protein. Additionally, those with APO-𝜖4 allele(s) have been found to have higher rates of CAA occurrence, and CAA is much more common in the elderly.