Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
  1. Home
  2. Books
  3. Neurodevelopment and Schizophrenia
  • Cited by 12
Publisher:
Cambridge University Press
Online publication date:
August 2010
Print publication year:
2004
Online ISBN:
9780511735103
DOI:
https://doi.org/10.1017/CBO9780511735103
Subjects:
Psychiatry and Clinical Psychology, Developmental Psychology, Medicine, Psychology, Psychiatry
Information

Book description

This book was originally published in 2004 and concerns developmental neurobiology. In the decade preceding publication, developmental neurobiology made important strides towards elucidating the pathophysiology of psychiatric disorders. Nowhere has this link between basic science and clinical insights become clearer than in the field of schizophrenia research. Each contributor to this volume provides a fresh overview of the relevant research, including directions for further investigation. The book begins with a section on advances in developmental neurobiology. This is followed by sections on etiological and pathophysiological developments, and models that integrate this knowledge. The final section addresses the clinical insights that emerge from the developmental models. This book will be valuable to researchers in psychiatry and neurobiology, students in psychology, and all mental health practitioners.

Reviews

Review of the hardback:'… an excellent book that delivers a scientific map of recent neurodevelopmental concepts.'

Source: British Journal of Neuroscience Nursing

Review of the hardback:'… a well-balanced and comprehensive overview that merits to be read by all students of this fascinating and devastating disorder.'

Source: Genes, Brain and Behaviour

Refine List

Actions for selected content:

Select all | Deselect all
  • View selected items
  • Export citations
  • Download PDF (zip)
  • Save to Kindle
  • Save to Dropbox
  • Save to Google Drive

Save Search

You can save your searches here and later view and run them again in "My saved searches".

Please provide a title, maximum of 40 characters.
Cancel
×

Contents

Page 2 of 2

Contents
  • 22 - Can one identify preschizophrenia children?
    pp 415-431
  • View abstract

    Summary

    Childhood antecedents of schizophrenia may variably reflect integral components of the schizophrenia diathesis, non-specific factors that potentiate this predisposition, or early manifestations of the disorder itself. This chapter explores the nature of the childhood antecedents of schizophrenia. It explores whether children who develop schizophrenia in adulthood are distinguishable from control children. The chapter examines how strong the association between the distinguishing features of preschizophrenia children as a group and the later development of the disorder is. It also explains ways we can identify preschizophrenia children on the basis of these characteristics. The early risk factors that flag the preschizophrenia status are also considered. Particular emphasis is on prospective population-based, high-risk, and follow-back studies. The measures investigated by the high-risk paradigm can aid in identification of truly vulnerable individuals within the high-risk population.
  • 23 - High-risk studies, brain development, and schizophrenia
    pp 432-454
    • By Matcheri S. Keshavan, University of Pittsburgh School of Medicine, Pittsburgh and Wayne State University School of Medicine, Detroit, USA
  • View abstract

    Summary

    This chapter reviews the several approaches to investigate premorbid risk for schizophrenia. It presents a critical appraisal of the existing studies focusing on the populations at risk for schizophrenia, the issues surrounding study design, predictive and outcome factors identified so far, and the timing of the studies. Studies of premorbid risk, risk for schizophrenia and prospective studies have utilized genetic propensity, neurobehavioral markers, or psychopathology to identify the risk status. The chapter outlines the potential merits and disadvantages of these strategies, reviews the lessons learned from the early first high-risk (HR) studies and presents a rationale for more focused next-generation studies to examine premorbid risk. Recent advances in developmental neurobiology and neuroscience make it reasonable to expect a paradigm shift in research on schizophrenia. It is hoped that the third millennium will usher in a new generation of research studies on high-risk (HR) populations.
  • 24 - Developmental models and hypothesis-driven early interventions in schizophrenia
    pp 455-472
    • By Matcheri S. Keshavan, University of Pittsburgh School of Medicine, Pittsburgh and Wayne State University School of Medicine, Detroit, USA, Barbara A. Cornblatt, Recognition and Prevention Program, Lake Success, New York, USA
  • View abstract

    Summary

    During recent years, three types of pathophysiological models have been proposed, those that posit altered pre- or perinatal brain development, those proposing peri-adolescent developmental abnormalities, and those that argue for neuronal degenerative processes after illness onset. This chapter reviews the lines of evidence from clinical observations and neurobiological research leading to the three seemingly conflicting models. It outlines an alternative model that potentially integrates all three. The chapter discusses the possible remediative and preventive treatment options suggested by the current pathophysiological models. It reviews the data that have emerged from the prevention programs generated by these models. The chapter is concluded by describing the way in which the unifying model newly proposed provides an integrated theoretical foundation for prevention and early intervention in schizophrenia. Evidence-based demonstration of cost effectiveness of such interventions is critically needed if this field of research is to sustain and solidify this paradigm shift.

Page 2 of 2

Metrics

Full text views

Total number of HTML views: 0
Total number of PDF views: 0 *
Loading metrics...

Book summary page views

Total views: 0 *
Loading metrics...

* Views captured on Cambridge Core between #date#. This data will be updated every 24 hours.

Usage data cannot currently be displayed.