Immunodeficiency diseases of the neonate

doi:10.1017/CBO9780511545306.014

12 - Immunodeficiency diseases of the neonate

Published online by Cambridge University Press: 10 August 2009

Matthew A. Saxonhouse and

John W. Sleasman

Edited by

Pedro A. de Alarcón and

Eric J. Werner

Foreword by

J. Lawrence Naiman

Show author details

Pedro A. de Alarcón: Affiliation:
University of Tennessee
Eric J. Werner: Affiliation:
Eastern Virginia Medical School
J. Lawrence Naiman: Affiliation:
Stanford University School of Medicine, California

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Summary

Introduction

Significant progress has been made towards the understanding of the clinical implications of the neonatal immune system and its immaturity. With the increasing survival of extremely premature infants, neonatologists and other physicians caring for these patients must be aware of the vulnerability of this select patient population. It is also important for neonatologists and pediatricians to be able to differentiate between immune immaturity and a true primary immunodeficiency that may present during the neonatal period. Failure to identify properly primary immunodeficiency diseases can result in delayed diagnosis and treatment, which can significantly affect the outcome of the disease. This chapter defines the immune immaturity of the neonate and how it impacts susceptibility to neonatal infection. It will describe the specific immune deficiency syndromes that may present during the neonatal period. Finally, the diagnosis and management of neonatal immunodeficiency diseases will be discussed in length in order to provide the reader with the proper approach and management guidelines to care adequately for these individuals.

Immaturity of the neonatal immune system

The immaturity of a neonate's immune response places the neonate at an increased risk for serious infection. An understanding of the development of the neonatal immune system is essential in order to be able to differentiate the clinical manifestations of infection associated with immaturity from those that identify a specific acquired or primary immunodeficiency disease. The focus of this section is to define how the immune immaturity of the neonate impacts susceptibility to infection.

Type: Chapter
Information: Neonatal Hematology , pp. 280 - 309

DOI: https://doi.org/10.1017/CBO9780511545306.014 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2005

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