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Chapter 17 - Functional Phagocyte Disorders in the Neonate

from Section V - Leucocyte Disorders

Published online by Cambridge University Press:  30 January 2021

By
Thomas F. Michniacki  and
Kelly Walkovich
Edited by
Pedro A. de Alarcón ,
Eric J. Werner ,
Robert D. Christensen  and
Martha C. Sola-Visner
Pedro A. de Alarcón
Affiliation:
University of Illinois College of Medicine
Eric J. Werner
Affiliation:
Children's Hospital of the King's Daughters
Robert D. Christensen
Affiliation:
University of Utah
Martha C. Sola-Visner
Affiliation:
Harvard University, Massachusetts
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Summary

In addition to quantitative neutrophil abnormalities, innate immunity, and thus risk of infection in a neonate, may be negatively impacted by qualitative phagocyte defects. The term phagocyte stems from the Greek “phagein” meaning “to eat or devour” and “cyte” meaning “cell” and refers to hematopoietic derived cells, namely monocytes, macrophages and neutrophils capable of engulfing and digesting microorganisms, foreign particles, and cellular debris. Neutrophils are also classified as granulocytes, given the characteristic presence of granules in their cytoplasm that play a key role in neutrophil function.

Type
Chapter
Information
Neonatal Hematology
Pathogenesis, Diagnosis, and Management of Hematologic Problems
 , pp. 279 - 292
Publisher: Cambridge University Press
Print publication year: 2021

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