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Chapter 16 - Eosinophils and Neutrophils

from Section V - Leucocyte Disorders

Published online by Cambridge University Press:  30 January 2021

By
Kurt R. Schibler  and
Robert D. Christensen
Edited by
Pedro A. de Alarcón ,
Eric J. Werner ,
Robert D. Christensen  and
Martha C. Sola-Visner
Pedro A. de Alarcón
Affiliation:
University of Illinois College of Medicine
Eric J. Werner
Affiliation:
Children's Hospital of the King's Daughters
Robert D. Christensen
Affiliation:
University of Utah
Martha C. Sola-Visner
Affiliation:
Harvard University, Massachusetts
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Summary

Eosinophilia in neonates is identified when the blood concentration of eosinophils exceeds the upper reference range limit. To avoid the potential pitfall of laboratory or technician error, perhaps the definition should be two subsequent eosinophil counts above the upper reference limit. The 95th percentile for blood concentration of eosinophils increases slightly over the first month following birth. Initially a count ≥1,200/µL would exceed the upper range, and by about four weeks a count of above 1,500/µL would exceed the upper limit [1]. This latter value is similar to that generally used to define eosinophilia in adults [2]. Adults with persistent eosinophilia are well advised to have the situation evaluated, because an association has been seen between persistent eosinophilia and end-organ damage [2]. Some adults with persistent eosinophilia have elevated blood Interkeukin-5 (IL-5) concentrations [3]. Some with hypereosinophilic syndrome have an eosinophilic leukemia involving a translocation in the tyrosine kinase gene [4].

Type
Chapter
Information
Neonatal Hematology
Pathogenesis, Diagnosis, and Management of Hematologic Problems
 , pp. 261 - 278
Publisher: Cambridge University Press
Print publication year: 2021

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