Chapter 5 considers the theology and moral philosophy of the respected theologian and moral casuist, Robert Sanderson. The divine Sanderson despaired of the unfortunate consequences for practical morality of denying the responsibility and freedom of individuals. In its historical context his doubt amounted to finally rejecting the Calvinist doctrine of predestination. Scholars consider Sanderson’s Several Cases of Conscience Discussed in Ten Lectures in the Divinity School at Oxford a main reference for Locke in the writing of the unpublished Two Tracts of Government and his foundational Essays on the Law of Nature. Sanderson’s work sets out a moral philosophy of free will reinforced by mechanical overtones of necessary causality in reasoning. The chapter briefly analyses this type of ‘mechanical conscience’ and shows how Sanderson was committed to a de facto theory of government.