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Sildenafil

Published online by Cambridge University Press:  20 February 2025

K. Ray Chaudhuri
Affiliation:
King's College London
Peter Jenner
Affiliation:
King's College London
Valentina Leta
Affiliation:
King's College London
Shelley Jones
Affiliation:
King's College London
Iro Boura
Affiliation:
St. George General Hospital of Chania, Crete, Greece
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Summary

Sildenafil citrate (5-[2-ethoxy-5-(4-methylpiperazin-1-ylsulfonyl)phenyl]-1,6-dihydro-1-methyl-3-propylpyrazolo[4,3-d]pyrimidin-7-one citrate; 1-{[3-(6,7-dihydro-1-methyl-7-oxo-3-propyl-1H-pyrazolo[4,3-d]pyrimidin-5-yl)-4-ethoxyphenyl]sulfonyl}-4-methylpiperazone citrate) is a phosphodiesterase-5 inhibitor with a molecular weight of 666.7 and a molecular formula of C22H30N6O4S,C6H8O7.

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Publisher: Cambridge University Press
Print publication year: 2025

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References

Suggested Reading

Bernard, BA, Metman, LV, Levine, L, Ouyang, B, Leurgans, S, Goetz, CG. Sildenafil in the treatment of erectile dysfunction in Parkinson’s disease. Mov Disord Clin Pract 2017; 4(3): 412415.CrossRefGoogle ScholarPubMed
Hussain, IF, Brady, CM, Swinn, MJ, Mathias, CJ, Fowler, CJ. Treatment of erectile dysfunction with sildenafil citrate (Viagra) in parkinsonism due to Parkinson’s disease or multiple system atrophy with observations on orthostatic hypotension. J Neurol Neurosurg Psychiatry 2001; 71(3): 371374.CrossRefGoogle ScholarPubMed
Raffaele, R, Vecchio, I, Giammusso, B, Morgia, G, Brunetto, MB, Rampello, L. Efficacy and safety of fixed-dose oral sildenafil in the treatment of sexual dysfunction in depressed patients with idiopathic Parkinson’s disease. Eur Urol 2002; 41(4): 382386.CrossRefGoogle ScholarPubMed
Zesiewicz, TA, Helal, M, Hauser, RA. Sildenafil citrate (Viagra) for the treatment of erectile dysfunction in men with Parkinson’s disease. Mov Disord 2000; 15(2): 305308.3.0.CO;2-W>CrossRefGoogle ScholarPubMed

References

AHFS Drug information, 2012. Bethesda: American Society of Health-System Pharmacists. Accessed on 31 December 2022 via www.medicinescomplete.com.Google Scholar
Bronner, G, Vodušek, DB. Management of sexual dysfunction in Parkinson’s disease. Ther Adv Neurol Disord 2011; 4(6): 375383.CrossRefGoogle ScholarPubMed
Joint Formulary Committee. British National Formulary (online). London: BMJ Group and Pharmaceutical Press. Accessed on 31 December 2022 via www.medicinescomplete.com.Google Scholar
Salonia, A, Rigatti, P, Montorsi, F. Sildenafil in erectile dysfunction: a critical review. Curr Med Res Opin 2003; 19(4): 241262.CrossRefGoogle ScholarPubMed
Sildenafil. In: Brayfield, A (Ed.), Martindale: The Complete Drug Reference. London: The Royal Pharmaceutical Society of Great Britain. Accessed on 31 December 2022 via www.medicinescomplete.com.Google Scholar
Sildenafil. In: DRUGDEX® System (electronic version). Truven Health Analytics, Greenwood Village, Colorado, USA. Accessed on 31 December 2022 via www.micromedexsolutions.com.Google Scholar
Smith, BP, Babos, M. Sildenafil. In: StatPearls. 2022, StatPearls Publishing. Copyright © 2022, Treasure Island (FL): StatPearls Publishing LLC.Google Scholar
Summary of product characteristics – Viagra 25 mg film-coated tablets. Upjohn UK Limited. Electronic Medicines Compendium: Viagra 25 mg film-coated tablets – summary of product characteristics (SmPC) – (emc). Accessed on 31 December 2022 via www.medicines.org.uk.Google Scholar

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  • Sildenafil
  • K. Ray Chaudhuri, King's College London, Peter Jenner, King's College London, Valentina Leta, King's College London, Shelley Jones, King's College London, Iro Boura, St. George General Hospital of Chania, Crete, Greece
  • Book: The Movement Disorders Prescriber's Guide to Parkinson's Disease
  • Online publication: 20 February 2025
  • Chapter DOI: https://doi.org/10.1017/9781009222648.047
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  • Sildenafil
  • K. Ray Chaudhuri, King's College London, Peter Jenner, King's College London, Valentina Leta, King's College London, Shelley Jones, King's College London, Iro Boura, St. George General Hospital of Chania, Crete, Greece
  • Book: The Movement Disorders Prescriber's Guide to Parkinson's Disease
  • Online publication: 20 February 2025
  • Chapter DOI: https://doi.org/10.1017/9781009222648.047
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Sildenafil
  • K. Ray Chaudhuri, King's College London, Peter Jenner, King's College London, Valentina Leta, King's College London, Shelley Jones, King's College London, Iro Boura, St. George General Hospital of Chania, Crete, Greece
  • Book: The Movement Disorders Prescriber's Guide to Parkinson's Disease
  • Online publication: 20 February 2025
  • Chapter DOI: https://doi.org/10.1017/9781009222648.047
Available formats
×