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Levodopa–Carbidopa–Entacapone Intestinal Gel

Published online by Cambridge University Press:  20 February 2025

K. Ray Chaudhuri ,
Peter Jenner ,
Valentina Leta ,
Shelley Jones  and
Iro Boura
K. Ray Chaudhuri
Affiliation:
King's College London
Peter Jenner
Affiliation:
King's College London
Valentina Leta
Affiliation:
King's College London
Shelley Jones
Affiliation:
King's College London
Iro Boura
Affiliation:
St. George General Hospital of Chania, Crete, Greece
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Summary

Levodopa (l-3,4-dihydroxyphenylalanine) has a molecular weight of 197.19 and a molecular formula of C9H11NO4.

Carbidopa ((+)-2-(3,4-dihydroxybenzyl)-2-hydrazinopropionic acid monohydrate; (–)-l-α-hydrazino-3,4-dihydroxy-α-methylhydrocinnamic acid monohydrate) has a molecular weight of 226.23 and a molecular formula of C10H14N2O4.

Entacapone ((E)-2-cyano-3-(3,4-dihydroxy-5-nitrophenyl)-N,N-diethyl-2-propenamide) has a molecular weight of 305.29 and a molecular formula of C14H15N3O5.

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Chapter
Information
The Movement Disorders Prescriber's Guide to Parkinson's Disease , pp. 210 - 219
Publisher: Cambridge University Press
Print publication year: 2025

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References

Suggested Reading

Leta, V, Dafsari, HS, Sauerbier, A, Metta, V, Titova, N, Timmermann, L, Ashkan, K, Samuel, M, Pekkonen, E, Odin, P, Antonini, A, Martinez-Martin, P, Parry, M, van Wamelen, DJ, Ray Chaudhuri, K. Personalised advanced therapies in Parkinson’s disease: the role of non-motor symptoms profile. J Pers Med 2021; 11(8): 773.CrossRefGoogle ScholarPubMed
Nyholm, D, Jost, WH. Levodopa–entacapone–carbidopa intestinal gel infusion in advanced Parkinson’s disease: real-world experience and practical guidance. Ther Adv Neurol Disord 2022; 15: 17562864221108018.CrossRefGoogle Scholar

References

Levodopa. In: Brayfield, A (Ed.), Martindale: The Complete Drug Reference. London: The Royal Pharmaceutical Society of Great Britain. Accessed on 12 November 2022 via www.medicinescomplete.com.Google Scholar

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