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Levodopa–Carbidopa

Published online by Cambridge University Press:  20 February 2025

K. Ray Chaudhuri ,
Peter Jenner ,
Valentina Leta ,
Shelley Jones  and
Iro Boura
K. Ray Chaudhuri
Affiliation:
King's College London
Peter Jenner
Affiliation:
King's College London
Valentina Leta
Affiliation:
King's College London
Shelley Jones
Affiliation:
King's College London
Iro Boura
Affiliation:
St. George General Hospital of Chania, Crete, Greece
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Summary

Levodopa (l-3,4-dihydroxyphenylalanine) has a molecular weight of 197.19 and a molecular formula of C9H11NO4.

Carbidopa ((+)-2-(3,4-dihydroxybenzyl)-2-hydrazinopropionic acid monohydrate; (–)-l-α-hydrazino-3,4-dihydroxy-α-methylhydrocinnamic acid monohydrate) has a molecular weight of 226.23 and a molecular formula of C10H14N2O4.

Type
Chapter
Information
The Movement Disorders Prescriber's Guide to Parkinson's Disease , pp. 191 - 199
Publisher: Cambridge University Press
Print publication year: 2025

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References

Suggested Reading

Tambasco, N, Romoli, M, Calabresi, P. Levodopa in Parkinson’s disease: current status and future developments. Curr Neuropharmacol. 2018; 16(8): 1239–1252. doi: 10.2174/1570159X15666170510143821. PMID: 28494719; PMCID: PMC6187751.CrossRefGoogle ScholarPubMed

References

AHFS Drug information, 2012. Bethesda: American Society of Health-System Pharmacists. Accessed on 1 November 2022 via www.medicinescomplete.com.Google Scholar
Carbidopa/levodopa. Brayfield, A (Ed.), Martindale: The Complete Drug Reference. London: The Royal Pharmaceutical Society of Great Britain. Accessed on 1 November 2022 via www.medicinescomplete.com.Google Scholar
Carbidopa/levodopa. In: DRUGDEX® System (electronic version). Truven Health Analytics, Greenwood Village, Colorado, USA. Accessed on 1 November 2022 via www.micromedexsolutions.com.Google Scholar
Joint Formulary Committee. British National Formulary (online). London: BMJ Group and Pharmaceutical Press. Accessed on 1 November 2022 via www.medicinescomplete.com.Google Scholar
Koschel, J, Ray Chaudhuri, K, Tönges, L, Thiel, M, Raeder, V, Jost, WH. Implications of dopaminergic medication withdrawal in Parkinson’s disease. J Neural Transm (Vienna) 2022; 129(9): 1169–1178.CrossRefGoogle ScholarPubMed
Summary of product characteristics – Sinemet Plus 25 mg/100 mg tablets. Organon Pharma (UK) Ltd. Electronic Medicines Compendium: Sinemet Plus 25 mg/100 mg tablets – summary of product characteristics (SmPC) – (emc). Accessed on 1 November 2022 via www.medicines.org.uk.Google Scholar

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