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Apomorphine Hydrochloride Subcutaneous Injection

Published online by Cambridge University Press:  20 February 2025

K. Ray Chaudhuri
Affiliation:
King's College London
Peter Jenner
Affiliation:
King's College London
Valentina Leta
Affiliation:
King's College London
Shelley Jones
Affiliation:
King's College London
Iro Boura
Affiliation:
St. George General Hospital of Chania, Crete, Greece
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Summary

Apomorphine hydrochloride (6aβ-aporphine-10,11-diol hydrochloride hemihydrate; (R)-10,11-dihydroxy-6a-aporphine hydrochloride hemihydrate; (6aR)-5,6,6a,7-tetrahydro-6-methyl-4H-dibenzo[de,g]quinoline-10,11-diol hydrochloride hemihydrate) has a molecular weight of 303.8 and a molecular formula of C17H18ClNO2.

Type
Chapter
Information
Publisher: Cambridge University Press
Print publication year: 2025

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References

Suggested Reading

Carbone, F, Djamshidian, A, Seppi, K, Poewe, W. Apomorphine for Parkinson’s disease: efficacy and safety of current and new formulations. CNS Drugs 2019; 33(9): 905918. doi: 10.1007/s40263-019-00661-z. PMID: 31473980; PMCID: PMC6776563.CrossRefGoogle Scholar
Titova, N, Chaudhuri, KR. Apomorphine therapy in Parkinson’s and future directions. Parkinsonism Relat Disord 2016; 33(Suppl 1): S56S60. doi: 10.1016/j.parkreldis.2016.11.013. Epub 2016 Nov 30. PMID: 27913125.CrossRefGoogle ScholarPubMed

References

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Auffret, M, Drapier, S, Vérin, M. Pharmacological insights into the use of apomorphine in Parkinson’s disease: clinical relevance. Clin Drug Investig 2018; 38(4): 287312.CrossRefGoogle ScholarPubMed
Chaudhuri, KR, Todorova, A, Nirenberg, MJ, Parry, M, Martin, A, Martinez-Martin, P, Rizos, A, Henriksen, T, Jost, W, Storch, A, Ebersbach, G, Reichmann, H, Odin, P, Antonini, A. A pilot prospective, multicenter observational study of dopamine agonist withdrawal syndrome in Parkinson’s disease. Mov Disord Clin Pract 2015; 2(2): 170174. doi: 10.1002/mdc3.12141. PMID: 30713891; PMCID: PMC6353371.CrossRefGoogle ScholarPubMed
Jenkins, JR, Pearce, JMS. Paradoxical akinetic response to apomorphine in parkinsonism. J Neurol Neurosurg Psychiatry 1992; 55: 414415.CrossRefGoogle ScholarPubMed
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Summary of Product Characteristics – APO-go pen 10 mg/ml solution for injection. Britannia Pharmaceuticals Limited. Electronic Medicines Compendium: APO-go Pen 10mg/ml Solution for Injection – Summary of Product Characteristics (SmPC) – (emc). Accessed on 5 December 2022 via www.medicines.org.uk.Google Scholar

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