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Amitriptyline

Published online by Cambridge University Press:  20 February 2025

K. Ray Chaudhuri ,
Peter Jenner ,
Valentina Leta ,
Shelley Jones  and
Iro Boura
K. Ray Chaudhuri
Affiliation:
King's College London
Peter Jenner
Affiliation:
King's College London
Valentina Leta
Affiliation:
King's College London
Shelley Jones
Affiliation:
King's College London
Iro Boura
Affiliation:
St. George General Hospital of Chania, Crete, Greece
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Summary

Amitriptyline hydrochloride (3-(10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-ylidene)-N,N-dimethylpropan-1-amine; hydrochloride) has a molecular weight of 313.9 and a molecular formula of C20H23N,HCl. Amitriptyline is usually given as the hydrochloride and doses are expressed in terms of this salt. Amitriptyline hydrochloride 75 mg is equivalent to about 66.3 mg of the base.

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Chapter
Information
The Movement Disorders Prescriber's Guide to Parkinson's Disease , pp. 16 - 29
Publisher: Cambridge University Press
Print publication year: 2025

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References

Suggested Reading

Antonini, A, Tesei, S, Zecchinelli, A, Barone, P, De Gaspari, D, Canesi, M, Sacilotto, G, Meucci, N, Mariani, C, Pezzoli, G. Randomized study of sertraline and low-dose amitriptyline in patients with Parkinson’s disease and depression: effect on quality of life. Mov Disord 2006; 21(8): 1119–1122.CrossRefGoogle ScholarPubMed
Cipriani, A, Furukawa, TA, Salanti, G, Chaimani, A, Atkinson, LZ, Ogawa, Y, Leucht, S, Ruhe, HG, Turner, EH, Higgins, JPT, Egger, M, Takeshima, N, Hayasaka, Y, Imai, H, Shinohara, K, Tajika, A, Ioannidis, JPA, Geddes, JR. Comparative efficacy and acceptability of 21 antidepressant drugs for the acute treatment of adults with major depressive disorder: a systematic review and network meta-analysis. Lancet 2018; 391(10128): 1357–1366.CrossRefGoogle ScholarPubMed
Serrano-Dueñas, M. [A comparison between low doses of amitriptyline and low doses of fluoxetin used in the control of depression in patients suffering from Parkinson’s disease]. Rev Neurol 2002; 35(11): 1010–1014 [in Spanish].Google ScholarPubMed

References

AHFS Drug Information, 2012. Bethesda: American Society of Health-System Pharmacists. Accessed on 4 December 2022 via www.medicinescomplete.com.Google Scholar
Amitriptyline. In: DRUGDEX® System (electronic version). Truven Health Analytics, Greenwood Village, Colorado, USA. Accessed on 4 December 2022 via www.micromedexsolutions.com.Google Scholar
Amitriptyline. In: Brayfield, A (Ed.), Martindale: The Complete Drug Reference. London: The Royal Pharmaceutical Society of Great Britain. Accessed on 4 December 2022 via www.medicinescomplete.com.Google Scholar
Greten, S, Müller-Funogea, JI, Wegner, F, Höglinger, GU, Simon, N, Junius-Walker, U, Gerbel, S, Krause, O, Klietz, M. Drug safety profiles in geriatric patients with Parkinson’s disease using the FORTA (Fit fOR The Aged) classification: results from a mono-centric retrospective analysis. J Neural Transm (Vienna) 2021; 128(1): 49–60.CrossRefGoogle ScholarPubMed
Joint Formulary Committee. British National Formulary (online). London: BMJ Group and Pharmaceutical Press. Accessed on 4 December 2022 via www.medicinescomplete.com.Google Scholar
Kuo, WY, Huang, KH, Kuan, YH, Chang, YC, Tsai, TH, Lee, CY. Antidepressants usage and risk of pneumonia among elderly patients with the Parkinson’s disease: a population-based case–control study. Front Med (Lausanne) 2022; 9: 740182.CrossRefGoogle Scholar
Lee, MY, Hong, S, Kim, N, Shin, KS, Kang, SJ. Tricyclic antidepressants amitriptyline and desipramine induced neurotoxicity associated with Parkinson’s disease. Mol Cells 2015; 38(8): 734–740.CrossRefGoogle ScholarPubMed
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Summary of Product Characteristics – Amitriptyline 10 mg film-coated tablets. Brown and Burk UK Ltd. Electronic Medicines Compendium: Amitriptyline 10 mg film-coated tablets – summary of product characteristics (SmPC) – (emc). Accessed on 4 December 2022 via www.medicines.org.uk.Google Scholar

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  • Amitriptyline
  • K. Ray Chaudhuri, King's College London, Peter Jenner, King's College London, Valentina Leta, King's College London, Shelley Jones, King's College London, Iro Boura, St. George General Hospital of Chania, Crete, Greece
  • Book: The Movement Disorders Prescriber's Guide to Parkinson's Disease
  • Online publication: 20 February 2025
  • Chapter DOI: https://doi.org/10.1017/9781009222648.004
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  • Amitriptyline
  • K. Ray Chaudhuri, King's College London, Peter Jenner, King's College London, Valentina Leta, King's College London, Shelley Jones, King's College London, Iro Boura, St. George General Hospital of Chania, Crete, Greece
  • Book: The Movement Disorders Prescriber's Guide to Parkinson's Disease
  • Online publication: 20 February 2025
  • Chapter DOI: https://doi.org/10.1017/9781009222648.004
Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

  • Amitriptyline
  • K. Ray Chaudhuri, King's College London, Peter Jenner, King's College London, Valentina Leta, King's College London, Shelley Jones, King's College London, Iro Boura, St. George General Hospital of Chania, Crete, Greece
  • Book: The Movement Disorders Prescriber's Guide to Parkinson's Disease
  • Online publication: 20 February 2025
  • Chapter DOI: https://doi.org/10.1017/9781009222648.004
Available formats
×