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Chapter 5 - Movement disorders of autoimmune origin

from Section II - Movement disorders in systemic disease

Published online by Cambridge University Press:  05 April 2014

By
José Fidel Baizabal-Carvallo  and
Joseph Jankovic
Edited by
Werner Poewe  and
Joseph Jankovic
José Fidel Baizabal-Carvallo
Affiliation:
Parkinson’s Disease Center and Movement Disorders Clinic, Baylor College of Medicine, Department of Neurology, Houston, TX, USA
Joseph Jankovic
Affiliation:
Baylor College of Medicine, Texas
Werner Poewe
Affiliation:
Medical University Innsbruck
Joseph Jankovic
Affiliation:
Baylor College of Medicine, Texas
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Summary

Introduction

Movement disorders (MDs) may present in a wide variety of autoimmune diseases affecting the nervous system. Some of these autoimmune disorders may be triggered by an infectious agent, such as Streptococcus in Sydenham’s disease, may occur in the setting of cancer, or with other autoimmune disorders associated with specific central nervous system (CNS) autoantibodies (Baizabal-Carvallo and Jankovic 2012). As infectious and paraneoplastic MDs will be reviewed elsewhere in this volume, they will not be included in this chapter.

In this chapter, we will review the MDs manifested as stiff person syndrome, encephalopathy associated with anti-thyroid antibodies, celiac disease, cerebral folate deficiency syndrome, systemic autoimmune and rheumatic diseases, and autoimmune vasculitis. The frequency of MDs varies according to the underlying disorder, and the phenomenology may be helpful to guide diagnostic tests of specific antibodies and treatment decisions. Table 5.1 provides a rapid overview of the most common autoimmune-related movement disorders.

Type
Chapter
Information
Movement Disorders in Neurologic and Systemic Disease , pp. 52 - 72
Publisher: Cambridge University Press
Print publication year: 2014

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