Disorders of Post-Translational Modifications/Degradation: Autophagy and Movement Disorders

Chapter 20 - Disorders of Post-Translational Modifications/Degradation: Autophagy and Movement Disorders

from Section II - A Metabolism-Based Approach to Movement Disorders and Inherited Metabolic Disorders

Published online by Cambridge University Press: 24 September 2020

Afshin Saffari and

Darius Ebrahimi-Fakhari

Edited by

Darius Ebrahimi-Fakhari and

Phillip L. Pearl

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Darius Ebrahimi-Fakhari: Affiliation:
Harvard Medical School
Phillip L. Pearl: Affiliation:
Harvard Medical School

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Summary

Autophagy is a term derived from the Ancient Greek word autóphagos, meaning “self-eating” or “self-devouring.” The term is used to describe a major cellular degradation process that ensures cellular quality control. By targeting dysfunctional cellular components and delivering them to the endosome–lysosome system for degradation, autophagy clears cells of cellular debris and recycles basic building blocks for de novo synthesis of cellular components.

Type: Chapter
Information: Movement Disorders and Inherited Metabolic Disorders
Recognition, Understanding, Improving Outcomes
, pp. 270 - 277

DOI: https://doi.org/10.1017/9781108556767 [Opens in a new window]

Publisher: Cambridge University Press

Print publication year: 2020

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