Published online by Cambridge University Press: 15 December 2009
The central thesis of this book is that tissues form when, as a result of their developmental history or current location, groups of cells within specific domains (the initial conditions) acquire new properties that render their existing organisation unstable. New structures then self-assemble as cells use these dynamic mechanisms within the context of local mechanical constraints (boundary conditions) to move to new, stable configurations (Chapter 7).
The set of morphogenetic mechanisms can be viewed as a toolkit, with cells using distinct subsets to form particular tissues. The following tables list the tools available to the two main cell types that build the early embryo, mesenchyme and epithelia, and it is worth noting that cell rearrangement is becoming the major mechanism for epithelial reorganisation. Although the list is long, I doubt that it is complete as I cannot see how these properties alone can account for complex shapes such as those of bones or the heart.
To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.
Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.
Find out more about the Kindle Personal Document Service.
To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.
To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.