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5 - Molecular Chaperones: The Unorthodox View

Published online by Cambridge University Press:  10 August 2009

By
Brian Henderson  and
Alireza Shamaei-Tousi
Edited by
Brian Henderson  and
A. Graham Pockley
Brian Henderson
Affiliation:
Division of Microbial Diseases, Eastman Dental Institute, University College London, London, United Kingdom
Alireza Shamaei-Tousi
Affiliation:
Division of Microbial Diseases, Eastman Dental Institute, University College London, London, United Kingdom
Brian Henderson
Affiliation:
University College London
A. Graham Pockley
Affiliation:
University of Sheffield
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Summary

Introduction

Like a Brian Rix farce, in which the characters' identities are continuously changing, the functions of the class of protein known as molecular chaperones has been unfolding continuously over the past decade resulting in substantial confusion. However, like such farces, we are confident that the dénouement will be a complete surprise and will provide a new world picture of the processes with which molecular chaperones are involved. This short chapter aims to introduce the reader to the rapidly changing world of molecular chaperones as an aid to the reading of the rest of the chapters in this volume.

Molecular chaperones are protein folders

Our story starts with a huff and a puff with the study of the response of the polytene chromosomes of Drosophila to various stressors. This revealed novel patterns of specific chromosomal puffs, in response to heat, and a variety of other environmental stresses, representing the transcription of selected genes [1, 2]. The behaviour of cells exposed to various stresses became known as the heat shock response or the cell stress response and we now appreciate the very large number of environmental factors to which cells will respond in this stereotypical manner. The ‘molecularisation’ of the cell stress response occurred in the late 1980s with the pioneering work of Ellis and colleagues [3], who introduced both the concept of protein chaperoning and the term molecular chaperone.

Type
Chapter
Information
Molecular Chaperones and Cell Signalling , pp. 78 - 96
Publisher: Cambridge University Press
Print publication year: 2005

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