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Chap 8 - FIBROMATOSES

Published online by Cambridge University Press:  01 March 2011

By
Markku Miettinen
Edited by
Markku Miettinen
Markku Miettinen
Affiliation:
Armed Forces Institute of Pathology, Washington DC
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Summary

The designation fibromatosis refers to a specific group of locally recurring and potentially aggressive but nonmetastasizing fibroblastic and myofibroblastic tumors. These include palmar and plantar fibromatosis, which are often together referred to as superficial fibromatoses. Penile fibromatosis (Peyronie's disease) is often attached to this group, although it is not certain whether it is truly comparable with other fibromatoses.

Deep, fascia-associated or intramuscular fibromatoses are called desmoid tumors, synonymously known as aggressive fibromatoses and musculoaponeurotic fibromatoses. All fibromatoses are composed of fibroblasts with a substantial myofibroblastic component. General features and clonal chromosomal changes suggest that both superficial and deep fibromatoses are clonal, neoplastic processes. Although there have been misgivings about the continuing use of the term desmoid fibromatosis (or briefly, desmoid), the existence of different types of fibromatoses (especially in childhood) justifies this as a specifying designation.

Some fibromatoses, such juvenile fibromatosis and lipofibromatosis, occur exclusively in children. Several childhood conditions called fibromatosis are not true fibromatoses, but reactive processes (fibromatosis colli), peculiar hyperplastic processes (gingival fibromatosis), or aberrations in morphogenesis (juvenile hyaline fibromatosis). These childhood lesions termed fibromatoses are discussed in Chapter 9.

PALMAR AND PLANTAR FIBROMATOSIS

Clinical Features

Palmar fibromatosis is also known as Dupuytren's contracture, named after an early nineteenth-century French surgeon who described this condition. Palmar fibromatosis is common especially in men of northern and eastern European, Scottish, and Irish descent.

Type
Chapter
Information
Modern Soft Tissue Pathology
Tumors and Non-Neoplastic Conditions
 , pp. 238 - 254
Publisher: Cambridge University Press
Print publication year: 2010

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References

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Fetsch, JF, Laskin, WB, Miettinen, M. Palmar-plantar fibromatosis in children and preadoleascents: A clinicopathological study of 56 cases with newly recognized demographics and extended follow-up information. Am J Surg Pathol 2005;29: 1095–1105.Google Scholar
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Aluisio, FV, Mair, SD, Hall, RL. Plantar fibromatosis: treatment of primary and recurrent lesions and factors associated with recurrence. Foot Ankle Int 1996;17:672–678.CrossRefGoogle ScholarPubMed
Zgonis, T, Jolly, GP, Polyzois, V, Kanuck, DM, Stamatis, ED. Plantar fibromatosis. Clin Podiatr Med Surg North Am 2005;22:11–18.CrossRefGoogle ScholarPubMed
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Graells Estrada, J, Garcia Fernandez, D, Badina Tottoella, F, Moreno Carzano, A. Familial plantar fibromatosis. Clin Exp Dermatol 2003;28:669–670.CrossRefGoogle ScholarPubMed
Luck, JV. Dupuytren's contracture: A new concept of the pathogenesis correlated with surgical management. J Bone Joint Surg Am 1959;41:635–664.CrossRefGoogle ScholarPubMed
Evans, HL. Multinucleated giant cell in plantar fibromatosis. Am J Surg Pathol 2002;26:244–248.CrossRefGoogle ScholarPubMed
Palma, L, Santucci, A, Gigante, A, Di Giulio, A, Carloni, S. Plantar fibromatosis: an immunohistochemical and ultrastructural study. Foot Ankle Int 1999;20:253–257.CrossRefGoogle ScholarPubMed
Dal Cin, P, Smet, L, Sciot, R, Damme, B, Berghe, H. Trisomy 7 and trisomy 8 in dividing and non-dividing tumor cells in Dupuytren's disease. Cancer Genet Cytogenet 1999;108:137–140.CrossRefGoogle ScholarPubMed
Casalone, R, Mazzola, D, Meroni, E, Righi, R, Minelli, E, Granata, P. Cytogenetic and interphase cytogenetic analyses reveal chromosome instability but no clonal trisomy 8 in Dupuytren contracture. Cancer Genet Cytogenet 1997;99:73–76.CrossRefGoogle ScholarPubMed
Wever, I, dal Cin, P, Fletcher, CDM, Mandahl, N, Mertens, F, Mitelman, F. Cytogenetic, clinical, and morphologic correlations in 78 cases of fibromatosis: A report from the CHAMP study group. Mod Pathol 2000;13:1080–1085.CrossRefGoogle ScholarPubMed
Breiner, JA, Nelson, M, Bredthauer, BD, Neff, JR, Bridge, JA. Trisomy 8 and trisomy 14 in plantar fibromatosis. Cancer Genet Cytogenet 1999;108:176–177.Google ScholarPubMed
Sawyer, JR, Sammartino, G, Godden, N, Nicholas, RW. A clonal reciprocal t(2;7)(p13;p13) in plantar fibromatosis. Cancer Genet Cytogenet 2005;158:67–69.CrossRefGoogle Scholar
Chansky, HA, Trumble, TE, Conrad, EU, Wolff, JF, Murray, LW, Raskind, WH. Evidence for a polyclonal etiology of palmar fibromatosis. J Hand Surg 1999;24:339–344.CrossRefGoogle ScholarPubMed
Montgomery, E, Lee, JH, Abraham, SC, Wu, TT. Superficial fibromatosis are genetically distinct from deep fibromatosis. Mod Pathol 2001;14:695–701.CrossRefGoogle Scholar
Bhattacharya, B, Dilworth, HP, Iacobuzio-Donahue, C, Ricci, F, Weber, K, Furlong, MA. Nuclear beta-catenin expression distinguishes deep fibromatosis from other benign and malignant fibroblastic and myofibroblastic lesions. Am J Surg Pathol 2005;29:653–659.CrossRefGoogle ScholarPubMed
Sommer, F, Schwarzer, U, Wassmer, G, Block, W, Braun, M, Klotz, T. Epidemiology of Peyronie's disease. Int J Impot Res 2002;14:379–383.CrossRefGoogle ScholarPubMed
Hellstrom, WJ, Bivalaqua, TJ. Peyronie's disease: etiology, medical and surgical therapy. J Androl 2000;21:347–354.Google ScholarPubMed
Smith, BH. Peyronie's disease. Am J Clin Pathol 1966;43:670–678.CrossRefGoogle Scholar
Davis, CJ. The microscopic pathology of Peyronie's disease. J Urol 1997;157:282–284.CrossRefGoogle ScholarPubMed
Ferenc, T, Sygut, J, Kopczynski, J, Mayer, M, Latos-Bielenska, A, Dziki, A. Aggressive fibromatosis (desmoid tumors): Definition, occurrence, pathology, diagnostic problems, clinical behavior, genetic background. Pol J Pathol 20006;57:5–15.Google Scholar
Reitamo, JJ, Häyry, P, Nykyri, E, Saxèn, E. The desmoid tumor. I. Incidence, sex-, age and anatomical distribution in the Finnish population. Am J Clin Pathol 1982;77:665–673.CrossRefGoogle ScholarPubMed
Lev, D, Kotilingam, D, Wei, C, Ballo, MT, Zagars, GK, Pisters, PWT. Optimizing treatment of desmoid tumors. J Clin Oncol 2007;25:1785–1791.CrossRefGoogle ScholarPubMed
Fallen, T, Wilson, M, Morlan, B, Lindor, NM. Desmoid tumors – a characterization of patients seen at Mayo clinic 1976–1999. Fam Cancer 2006;5:191–194.CrossRefGoogle Scholar
Heiskanen, I, Järvinen, H. Occurrence of desmoid tumours in familial adenomatous polyposis and results of treatment. Int J Colorectal Dis 1996;11:157–162.CrossRefGoogle ScholarPubMed
Posner, MC, Shiu, MH, Newsome, JL, Hajdu, SI, Gaynor, JJ, Brennan, MF. The desmoid tumor. Not a benign disease. Arch Surg 1989;124:191–196.CrossRefGoogle Scholar
Brasfield, RD. Das Gupta, TK. Desmoid tumors of the anterior abdominal wall. Surgery 1969;65:241–246.Google ScholarPubMed
Häyry, P, Reitamo, JJ, Totterman, S, Hopfner-Hallikainen, D, Sivula, A. The desmoid tumor. II. Analysis of factors possibly contributing to the etiology and growth behavior. Am J Clin Pathol 1982;77:674–680.CrossRefGoogle ScholarPubMed
Pignatti, G, Barbanti-Brodano, G, Ferrari, D, Gherlinzoni, F, Bertoni, F, Bacchni, P. Extra-abdominal desmoid tumor. A study of 83 cases. Clin Orthop Relat Res 2000;375:207–213.CrossRefGoogle Scholar
Gronchi, A, Casali, PG, Mariani, L, Lo Vullo, S, Colecchia, M, Lozza, L. Quality of surgery and outcome in extra-abdominal aggressive fibromatosis: a series of patients surgically treated at a single institution. J Clin Oncol 2003;21:1390–1397.CrossRefGoogle Scholar
Merchant, NB, Lewis, JJ, Woodruff, JM, Leung, DH, Brennan, MF. Extremity and trunk desmoid tumors. Cancer 1999;86: 2045–2052.3.0.CO;2-F>CrossRefGoogle ScholarPubMed
Hosalkar, HS, Fox, EJ, Delaney, T, Torbert, JT, Ogilvie, CM, Lackman, RD. Desmoid tumors and current status of management. Orthop Clin North Am 2006;37:53–63.CrossRefGoogle ScholarPubMed
Rock, MG, Pritchard, DJ, Reiman, HM, Soule, EH, Brewster, AR. Extra-abdominal desmoid tumors. J Bone Joint Surg Am 1984;66:1369–1374.CrossRefGoogle ScholarPubMed
Abraham, SC, Reynolds, C, Lee, JH, Montgomery, EA, Baisden, BL, Krasinskas, AM, Wu, TT. Fibromatosis of the breast and mutations involving the APC/beta-catenin pathway. Hum Pathol 2002;33:39–46.CrossRefGoogle ScholarPubMed
Aaron, AD, O'Mara, JW, Legendre, KE, Evans, SR, Attinger, CE, Montgomery, EA. Chest wall fibromatosis associated with silicone implants. Surg Oncol 1996;5:93–99.CrossRefGoogle Scholar
Burke, AP, Sobin, LH, Shekitka, KM, Federspiel, BH, Helwig, EB. Intara-abdominal fibromatosis. A pathologic analysis of 130 tumors with comparison of clinical subgroups. Am J Surg Pathol 1990;14:335–341.CrossRefGoogle ScholarPubMed
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  • FIBROMATOSES
  • Edited by Markku Miettinen, Armed Forces Institute of Pathology, Washington DC
  • Book: Modern Soft Tissue Pathology
  • Online publication: 01 March 2011
  • Chapter DOI: https://doi.org/10.1017/CBO9780511781049.009
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  • FIBROMATOSES
  • Edited by Markku Miettinen, Armed Forces Institute of Pathology, Washington DC
  • Book: Modern Soft Tissue Pathology
  • Online publication: 01 March 2011
  • Chapter DOI: https://doi.org/10.1017/CBO9780511781049.009
Available formats
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  • FIBROMATOSES
  • Edited by Markku Miettinen, Armed Forces Institute of Pathology, Washington DC
  • Book: Modern Soft Tissue Pathology
  • Online publication: 01 March 2011
  • Chapter DOI: https://doi.org/10.1017/CBO9780511781049.009
Available formats
×