Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-78c5997874-m6dg7 Total loading time: 0 Render date: 2024-11-06T09:55:46.044Z Has data issue: false hasContentIssue false

Chap 15 - ATYPICAL LIPOMATOUS TUMOR AND LIPOSARCOMAS

Published online by Cambridge University Press:  01 March 2011

By
Markku Miettinen
Edited by
Markku Miettinen
Markku Miettinen
Affiliation:
Armed Forces Institute of Pathology, Washington DC
Get access

Summary

Atypical lipomatous tumors and four clinicopathologically or genetically distinct types of liposarcomas, sarcomas with fatty differentiation, are discussed in this chapter. Table 15.1 reviews their clinicopathologic features. The diagnosis of liposarcoma is based on recognition of adipocytic atypia and the characteristic histologic patterns for each type of liposarcoma. Fat stains are not useful, because fat is present in other tumors, for example in malignant fibrous histiocytoma (MFH, undifferentiated sarcoma) and in nonsarcomatous tumors, such as renal cell carcinoma. Immunostains are of limited value. The present classification of liposarcoma has evolved especially by work by Enterline et al., Enzinger et al., and Evans.

Well-differentiated liposarcoma and atypical lipomatous tumor are considered synonymous in the World Health Organization (WHO) classification. In this text, however, their clinical discussion is separated so that subcutaneous lesions are designated as atypical lipomatous tumors, whereas morphologically similar intramuscular, inguinal, mediastinal, and intraabdominal (retroperitoneal) tumors are designated as well-differentiated liposarcomas because of their greater tendency to uncontrollable local recurrences and dedifferentiation. The latter refers to their evolution into a nonlipomatous sarcoma phenotype. Despite some tendencies for different morphology in subcutaneous versus deep tumors, there are no criteria that could morphologically distinguish an atypical lipomatous tumor from a well-differentiated liposarcoma. Both types are characterized by 12q13–15 amplification; this genomic segment includes genes such as murine double minute (MDM2).

Dedifferentiated liposarcoma is a transformed variant of well-differentiated liposarcoma, representing its histologic and biologic disease progression. This type is most common in the retroperitoneum.

Type
Chapter
Information
Modern Soft Tissue Pathology
Tumors and Non-Neoplastic Conditions
 , pp. 432 - 459
Publisher: Cambridge University Press
Print publication year: 2010

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Enterline, HT, Culberson, JD, Rochlin, DB, Brady, LW. Liposarcoma: A clinical and pathological study of 53 cases. Cancer 1960;13:932–950.3.0.CO;2-S>CrossRefGoogle ScholarPubMed
Enzinger, FM, Winslow, DJ. Liposarcoma: a study of 103 cases. Virchows Arch Anat Pathol [A] 1962;335:367–388.CrossRefGoogle ScholarPubMed
Evans, HL. Liposarcoma: a study of 55 cases with a reassessment of its classification. Am J Surg Pathol 1979;3:507–523.CrossRefGoogle ScholarPubMed
Dei Tos, AP, Pedeutour, F. Atypical lipomatous tumor/well-differentiated liposarcoma. In: Pathology and Genetics of Tumours of Soft Tissue and Bone, Editors Fletcher, CDM, Unni, KK, Lyon, Mertens F., World Health Organization, 2002, pp. 35–37.Google Scholar
Demetri, GD, Fletcher, CD, Mueller, E, Sarraf, P, Naujoks, R, Campbell, N. Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma. Proc Natl Acad Sci USA 1999;96:3951–3956.CrossRefGoogle ScholarPubMed
Singer, S, Socci, ND, Ambrosini, G, Sambol, E, Decarolis, P, Wu, Y. Gene expression profiling of liposarcoma identifies distinct biological types/subtypes and potential therapeutic targets in well-differentiated and dedifferentiated liposarcoma. Clin Cancer Res 2007;67:6626–6636.Google ScholarPubMed
Müller, CR, Paulsen, EB, Noordhuis, P, Pedeutour, F, Saeter, G, Myklebost, O. Potential for treatment of liposarcomas with the MDM2 antagonist Nutlin-3A. Int J Cancer 2007;121:195–201.CrossRefGoogle ScholarPubMed
Azumi, N, Curtis, J, Kempson, RL. Atypical and malignant neoplasms showing lipomatous differentiation: A study of 111 cases. Am J Surg Pathol 1987;11:161–183.CrossRefGoogle ScholarPubMed
Allen, PW, Strungs, I, MacCormac, LB. Atypical subcutaneous fatty tumors: a review of 37 referred cases. Pathology 1988;30:123–135.CrossRefGoogle Scholar
Evans, HL, Soule, EH, Winkelmann, RK. Atypical lipoma, atypical intramuscular lipoma, and well-differentiated retroperitoneal liposarcoma: a reappraisal of 30 cases formerly classified as well-differentiated liposarcoma. Cancer 1979;43:574–584.3.0.CO;2-7>CrossRefGoogle ScholarPubMed
Evans, HL. Liposarcomas and atypical lipomatous tumors: A study of 66 cases followed for a minimum of 10 years. Surg Pathol 1988;1:41–54.Google Scholar
Kindblom, LG, Angervall, L, Fassina, AS. Atypical lipoma. Acta Pathol Microbiol Immunol Scand [A] 1982;90:27–36.Google ScholarPubMed
Yoshikawa, H, Ueda, T, Mori, S, Araki, N, Myoui, A, Uchida, A. Dediffrentiated liposarcoma of the subcutis. Am J Surg Pathol 1996;20:1525–1530.CrossRefGoogle ScholarPubMed
Austin, RM, Dupree, WB. Liposarcoma of the breast: A clinicopathologic study of 20 cases. Hum Pathol 1986;17:906–913.CrossRefGoogle ScholarPubMed
Powell, CM, Rosen, PP. Adipose differentiation in cystosarcoma phyllodes: A study of 14 cases. Am J Surg Pathol 1994; 18:720–727.CrossRefGoogle ScholarPubMed
Kindblom, LG, Angervall, L, Svendsen, P. Liposarcoma: a clinicopathologic, radiographic, and prognostic study. Acta Pathol Microbiol Scand 1992; 253 (Suppl).Google Scholar
Weiss, SW, Rao, VK. Well-differentiated liposarcoma (atypical lipoma) of deep soft tissue of the extremities, retroperitoneum, and miscellaneous sites: A follow-up study of 92 cases with analysis of the incidence of “dedifferentiation.”Am J Surg Pathol 1992;167:1051–1058.CrossRefGoogle Scholar
Lucas, DR, Nascimento, AG, Sanjay, BK, Rock, MG. Well-differentiated liposarcoma: The Mayo clinic experience with 58 cases. Am J Clin Pathol 1994;102:677–683.CrossRefGoogle Scholar
Montgomery, EA, Fisher, C. Paratesticular liposarcoma: a clinicopathologic study. Am J Surg Pathol 2003;27:40–47.CrossRefGoogle ScholarPubMed
Klimstra, DS, Moran, CA, Perino, G, Koss, MN, Rosai, J. Liposarcoma of the anterior mediastinum and thymus: A clinicopathologic study of 28 cases. Am J Surg Pathol 1995;19: 782–791.CrossRefGoogle ScholarPubMed
Hahn, HP, Fletcher, CD. Primary mediastinal liposarcoma: Clinicopathologic analysis of 24 cases. Am J Surg Pathol 2007;31:1868–1874.CrossRefGoogle ScholarPubMed
Wenig, BM, Weiss, SW, Gnepp, DR. Laryngeal and hypopharyngeal liposarcoma: A clinicopathologic study of 10 cases with a comparison to soft-tissue counterparts. Am J Surg Pathol 1990;14:134–141.CrossRefGoogle ScholarPubMed
Argani, P, Facchetti, F, Inghirami, G, Rosai, J. Lymphocyte-rich well-differentiated liposarcoma: report of nine cases. Am J Surg Pathol 1997:21;884–895.CrossRefGoogle ScholarPubMed
Kraus, MD, Guillou, L, Fletcher, CD. Well-differentiated inflammatory liposarcoma: an uncommon and easily overlooked variant of a common sarcoma. Am J Surg Pathol 1997; 21:518–527.CrossRefGoogle ScholarPubMed
Dei Tos, AP, Mentzel, , Newman, PL, Fletcher, CDM. Spindle cell liposarcoma, a hitherto unrecognized variant of liposarcoma. Am J Surg Pathol 1994;18:913–921.CrossRefGoogle ScholarPubMed
Suster, S.Fisher, C.CD34 in lipomatous tumors. Am J Surg Pathol 1997;195–200.CrossRefGoogle ScholarPubMed
Dei Tos, AP, Doglioni, C, Piccinin, S, Sciot, R, Furlanetto, A, Boiocchi, M. Coordinated expression and amplification of the MDM2, CDK4, and HMGI-C genes in atypical lipomatous tumors. J Pathol 2000;190:531–536.3.0.CO;2-W>CrossRefGoogle Scholar
Pilotti, S, Della Torre, G, Mezzelani, A, Tamborini, E, Azzarelli, A, Sozzi, G. The expression of MDM2/CDK4 gene product in the differential diagnosis of well-differentiated liposarcoma and large deep-seated lipoma. Br J Cancer 2000;82:1271–1275.CrossRefGoogle ScholarPubMed
Binh, MB, Sastre-Garau, X, Guillou, L, Pinieux, G, Terrier, P, Lagace, R. MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. Am J Surg Pathol 2005;29:1340–1347.CrossRefGoogle ScholarPubMed
Remstein, E, Kurtin, PJ, Nascimento, AG. Sclerosing extramedullary hematopoietic tumor in chronic myeloproliferative disorders. Am J Surg Pathol 2000;24:51–55.CrossRefGoogle ScholarPubMed
Stephenson, CF, Berger, CS, Leong, SP, Davis, JR, Sandberg, AA. Analysis of a giant marker chromosome in well-differentiated liposarcoma using cytogenetics and fluorescence in situ hybridization. Cancer Genet Cytogenet 1992;15:134–138.CrossRefGoogle Scholar
Dal Cin, P, Kools, P, Sciot, R, Wever, I, can Damme, B, Wen, W. Cytogenetic and fluorescence in situ hybriization investigation of ring chromosomes characterizing a specific pathologic subgroup of adipose tissue tumors. Cancer Genet Cytogenet 1993;68:85–90.CrossRefGoogle ScholarPubMed
Pedeutour, F, Suikerbuijk, RF, Forus, A, Gaal, J, Klundert, W, Coindre, JM. Complex composition and co-amplification of SAS and MDM2 in ring and giant rod marker chromosomes in well-differentiated liposarcomas. Genes Chromosomes Cancer 1994;10:85–94.CrossRefGoogle Scholar
Szymanska, J, Virolainen, M, Tarkkanen, M, Wiklund, T, Asko-Seljavaara, S, Tukiainen, E. Overrepresentation of 1q21–23 and 12q13–21 in lipoma-like liposarcomas but not in benign lipomas: A comparative genomic hybridization study. Cancer Genet Cytogenet 1997;99:14–18.CrossRefGoogle Scholar
Rosai, J, Akerman, M, Dal Cin, P, Wever, I, Fletcher, CDM, Mandahl, N. Combined morphologic and karyotypic study of 59 atypical lipomatous tumors: Evaluation of their relationship and differential diagnosis with other adipose tissue tumors. A report of the CHAMP study group. Am J Surg Pathol 1996;20:1182–1189.CrossRefGoogle ScholarPubMed
Henricks, W, Chu, YC, Goldblum, JR, Weiss, SW. Dedifferentiated liposarcoma. A clinicopathological analysis of 155 cases with a proposal for an expanded definition of dedifferentiation. Am J Surg Pathol 1997;21:271–281.CrossRefGoogle ScholarPubMed
Kransdorf, MJ, Meis, JM, Jelinek, JS. Dedifferentiated liposarcoma of the extremities: imaging finding in four patients. AJR Am J Roentgenol 1993;161:127–130.CrossRefGoogle Scholar
Hisaoka, M, Morimitsu, Y, Hashimoto, H, Ishida, T, Mukai, H, Satoh, H. Retroperitoneal liposarcoma with combined well-differentiated and myxoid malignant fibrous histiocytoma-like myxoid areas. Am J Surg Pathol 1999; 23:1480–1492.CrossRefGoogle ScholarPubMed
Coindre, JM, Hostein, I, Maire, G, Derre, J, Guillou, LLeroux, A. Inflammatory malignant fibrous histicytomas and dedifferentiated liposarcomas: histologic review, genetic profile, and MDM2 and CDK4 status favor a single entity. J Pathol 2004:128–1523–1529.Google Scholar
Coindre, JM, Mariani, O, Chibon, F, Mairal, A, Saint Aubain Somerhausen, N, Favre-Guillevin, E. Most malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcomas: a review of 25 cases initially diagnosed as malignant fibrous histiocytomas. Mod Pathol 2003;16:256–262.CrossRefGoogle ScholarPubMed
McCormick, D, Mentzel, T, Beham, A, Fletcher, CDM. Dedifferentiated liposarcoma: Clinicopathologic analysis of 32 cases suggesting a better prognostic subgroup among pleomorphic sarcomas. Am J Surg Pathol 1994;18:1213–1223.CrossRefGoogle ScholarPubMed
Elgar, F, Goldblum, JR. Well-differentiated liposarcoma of the retroperitoneum: a clinicopathologic analysis of 20 cases, with particular attention to the extent of low-grade dedifferentiation. Mod Pathol 1997;10:113–120.Google ScholarPubMed
Hasegawa, T, Seki, K, Hasegawa, F, Matsuno, Y, Shimoda, T, Horose, T. Dedifferentiated liposarcoma of retroperitoneum and mesentery: Varied growth patterns and histological grades - A clinicopathologic study of 32 cases. Hum Pathol 2000;31:717–727.CrossRefGoogle ScholarPubMed
Nascimento, AG, Kurtin, PJ, Guillou, L, Fletcher, CD. Dedifferentiated liposarcoma: a report of nine cases with a peculiar neurallike whorling pattern associated with metaplastic bone formation. Am J Surg Pathol 1998;22:945–955.CrossRefGoogle ScholarPubMed
Fanburg-Smith, J, Miettinen, M. Liposarcoma with meningothelial whorls: An analysis of 17 cases of a distinctive histologic pattern associated with dedifferentiated liposarcoma. Histopathology 1998;33:414–424.CrossRefGoogle Scholar
Nicolas, M, Moran, CA, Suster, S. Pulmonary metastasis from liposarcoma: a clinicopathologic and immunohistochemical study of 24 cases. Am J Clin Pathol 2005;123:265–275.CrossRefGoogle ScholarPubMed
Huang, HY, Brennan, MF, Singer, S, Antonescu, CR. Distant metastases in retroperitoneal dedifferentiated liposarcoma is rare and rapidly fatal: a clinicopathologic study with emphasis on the low-grade myxofibrosarcomatous patten as an early sign of differentiation. Mod Pathol 2005;18:976–984.CrossRefGoogle Scholar
Tallini, G, Erlandson, RA, Brennan, MF, Woodruff, JM. Divergent myosarcomatous differentiation in retroperitoneal liposarcoma. Am J Surg Pathol 1993;17:546–556.CrossRefGoogle ScholarPubMed
Evans, HL, Khurana, KK, Kemp, BL, Ayala, AG. Heterologous elements in the dedifferentiated component of dedifferentiated liposarcoma. Am J Surg Pathol 1994;18:1150–1157.CrossRefGoogle ScholarPubMed
Suster, S, Wong, TY, Moran, CA. Sarcomas with combined features of liposarcoma and leiomyosarcoma: Study of two cases of an unusual soft tissue tumor showing dual lineage differentiation. Am J Surg Pathol 1993;17:905–911.CrossRefGoogle ScholarPubMed
Folpe, ALWiess, SW. Lipoleiomyosarcoma (well-differentiated liposarcoma with leiomyosarcomatous differentiation): a clinicopathologic study of nine cases including one with dedifferentiation. Am J Surg Pathol 2002;26: 742–749.CrossRefGoogle ScholarPubMed
Binh, MBN, Guillou, L, Hostein, I, Chateau, MC, Collin, F, Aurias, A. Dedifferentiated liposarcomas with divergent myosarcomatous differentiation developed in the internal trunk: A study of 27 cases and comparison to conventional dedifferentiated liposarcomas and leiomyosarcomas. Am J Surg Pathol 2007;31:1557–1566.CrossRefGoogle ScholarPubMed
Macarenco, RS, Erickson-Johnson, M, Wang, X, Jenkins, RB, Nascimentoa, AG, Oliveira, AM. Cytogenetic and molecular cytogenetic findings in dedifferentiated liposarcoma with neural-like whirling pattern and metaplastic bone formation. Cancer Genet Cytogenet 2007;172:147–150.CrossRefGoogle Scholar
Nishio, J, Iwasaki, H, Ishiguro, M, Ohjimi, Y, Fujita, C, Ikegami, H. Establishment of a novel human dedifferentiated liposarcoma cell line, FU-DDLS-1: conventional and molecular cytogenetic characterization. Int J Oncol 2003;22:535–542.Google ScholarPubMed
Takahira, T, Oda, Y, Tamiya, S, Yamamoto, H, Kobayashi, C, Izumi, T. Alterations of the RB1 gene in dedifferentiated liposarcoma. Mod Pathol 2005;18:1461–1470.CrossRefGoogle ScholarPubMed
Fritz, B, Schubert, F, Wrobel, G, Schwaenen, C, Wessendorf, S, Nessling, M. Microarray-based copy number and expression profiling in dedifferentiated and pleomorphic liposarcomas. Cancer Res 2002;62:2993–2998.Google Scholar
Kilpatrick, SE, Doyon, J, Choong, PF, Sim, FH, Nascimento, AG. The clinicopathologic spectrum of myxoid and round cell liposarcoma: A study of 95 cases. Cancer 1996;77:1450–1458.3.0.CO;2-G>CrossRefGoogle ScholarPubMed
Shmookler, BM, Enzinger, FM. Liposarcomas occurring in children: an analysis of 17 cases and review of the literature. Cancer 1983;53:567–574.3.0.CO;2-4>CrossRefGoogle Scholar
Miller, GG, Yanchar, NL, Magee, JF, Blair, GK. Lipoblastoma and liposarcoma in children: an analysis of 9 cases and a review of the literature. Can J Surg 1998;41:455–458.Google Scholar
Quaglia, MP, Spiro, SA, Ghavimi, F, Hajdu, SI, Meyers, P, Exelby, PR. Liposarcoma in patients younger than or equal to 22 years of age. Cancer 1993;72:3114–3119.3.0.CO;2-I>CrossRefGoogle ScholarPubMed
Smith, TA, Easley, KA, Goldblum, JR. Myxoid/round cell liposarcoma of the extremities: A clinicopathologic study of 29 cases with particular attention to extent of round cell liposarcoma. Am J Surg Pathol 1996;20:171–180.CrossRefGoogle ScholarPubMed
Antonescu, CR, Elahi, A, Healey, JH, Brennan, MF, Lui, MY, Lewis, J. Monoclonality of multifocal myxoid liposarcoma: confirmation by analysis of TLS-CHOP or EWS-CHOP rearrangements. Clin Cancer Res 2000;6:2788–2793.Google ScholarPubMed
Spillane, AJ, Fisher, C, Thomas, JM. Myxoid liposarcoma – the frequency and the natural history of nonpulmonary soft tissue metastases. Ann Surg Oncol 1999;6:389–394.CrossRefGoogle ScholarPubMed
Fukuda, T, Oshiro, Y, Yamamoto, I, Tsuneyoshi, M. Long-term follow-up of pure myxoid liposarcomas with special reference to local recurrence and progression to round cell lesions. Pathol Int 1999;49:710–715.CrossRefGoogle ScholarPubMed
Patel, SR, Burgess, MA, Plager, C, Papadopoulos, NE, Linke, KA, Benjamin, RS. Myxoid liposarcoma: Experience with chemotherapy. Cancer 1994;74:1265–1269.3.0.CO;2-X>CrossRefGoogle ScholarPubMed
Siebert, JD, Williams, RP, Pulitzer, DR. Myxoid liposarcoma with cartilaginous differentiation. Mod Pathol 1996;9:249–252.Google ScholarPubMed
Engstrom, K, Bergh, P, Cederlund, CG, Hultborn, R, Willen, H, Aman, P. Irradiation of myxoid/round cell liposarcoma induces volume reduction and lipoma-like morphology. Acta Oncol 2007;46:838–845.CrossRefGoogle ScholarPubMed
DeiTos, AP, Piccinin, S, Doglioni, C, Vukosavljevic, T, Mentzel, T, Boiocchi, M. Molecular aberrations of the G1-S checkpoint in myxoid and round cell liposarcoma. Am J Pathol 1997;151:1531–1539.Google Scholar
Oliveira, AM, Nascimento, AG, Okuno, SH, Lloyd, RV. P27 (kip1) protein expression correlates with survival in myxoid and round-cell liposarcoma. J Clin Oncol 2000;18:2888–2893.CrossRefGoogle ScholarPubMed
Oda, Y, Yamamoto, H, Takahira, T, Kobayashi, C, Kawaguchi, K, Tateishi, N. Frequent alteration of p16(INK4a)/p14(ARF) and p53 pathways in the round cell component of myxoid/round cell liposarcoma: p53 gene alterations and reduced p14 (ARF) expression both correlate with poor prognosis. J Pathol 2005;207:410–421.CrossRefGoogle ScholarPubMed
Crozat, A, Aman, P, Mandahl, N, Ron, D. Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature 1993;363:640–644.CrossRefGoogle ScholarPubMed
Panagopoulos, I, Mandahl, N, Ron, D, Hoglund, M, Nilbert, M, Mertens, F. Characterization of the CHOP breakpoints and fusion transcripts in myxoid liposarcomas with the 12;16 translocation. Cancer Res 1994;54:6500–6503.Google ScholarPubMed
Gibas, Z, Miettinen, M, Limon, J, Nedoszytko, B, Mrozek, K, Roszkiewicz, et al . Cytogenetic and immunohistochemical profile of myxoid liposarcoma. Am J Clin Pathol 1995; 103:20–26.CrossRefGoogle ScholarPubMed
Knight, JC, Renwick, PJ, Dal Cin, PD, Berghe, H, Fletcher, CD. Translocation t(12;16)(q13;p11) in myxoid liposarcoma and round cell liposarcoma: molecular and cytogenetic analysis. Cancer Res 1995;55:24–27.Google Scholar
Tallini, G, Akerman, M, Dal Cin, P, Wewer, I, Fletcher, CD, Mandahl, N. Combined morphologic and karyotypic study of 28 myxoid liposarcomas: Implications for a revised morphological typing (a report from the CHAMP-group). Am J Surg Pathol 1996;20:1047–1055.CrossRefGoogle Scholar
Panagopoulos, I, Mandahl, N, Mitelman, F, Aman, P. Two distinct FUS breakpoint clusters in myxoid liposarcoma and acute myeloid leukemia with the translocations t(12;16) and t(16;21). Oncogene 1995;11:1133–1137.Google Scholar
Panagopoulos, I, Hoglund, M, Mertens, F, Mandahl, N, Mitelman, F, Aman, P. Fusion of the EWS and CHOP genes in myxoid liposarcoma. Oncogene 1996;12:489–494.Google ScholarPubMed
Dal Cin, P, Sciot, R, Panagopuolos, I, Aman, P, Samson, I, Mandahl, N. Additional evidence of a variant translocation t(12;22) with EWS/CHOP fusion in myxoid liposarcoma: clinicopathological features. J Pathol 1997;182: 437–441.3.0.CO;2-X>CrossRefGoogle Scholar
Panagopoulos, I, Lassen, C, Isaksson, M, Mitelman, F, Mandahl, N, Aman, P. Characteristic sequence motifs at the breakpoints of the hybrid genes FUS/CHOP, EWS/CHOP and FUS/ERG in myxoid liposarcoma and acute myeloid leukemia. Oncogene 1997;15:1357–1362.CrossRefGoogle ScholarPubMed
Kuroda, M, Ishida, T, Horiuchi, H, Kida, N, Uozaki, H, Takeuchi, H. Chimeric TLS/FUS-CHOP gene expression and the heterogeneity of its junction in human myxoid and round cell liposarcoma. Am J Pathol 1995;147:1221–1227.Google ScholarPubMed
Kuroda, M, Wang, X, Sok, J, Yin, Y, Chung, P, Giannotti, JW. Induction of a secreted protein by the myxoid liposarcoma oncogene. Proc Natl Acad Sci (USA) 1999;96:5025–5030.CrossRefGoogle ScholarPubMed
Adelmant, G, Gilbert, JD, Freytag, SO. Human translocation liposarcoma-CCAAT/enhancer binding protein (C/EBP) homologous protein (TLS/CHOP) oncoprotein prevents adipocyte differentiation by directly interfering with C/EBPbeta function. J Biol Chem 1998;273:15574–15581.CrossRefGoogle Scholar
Engstrom, K, Willen, H, Kabjorn-Gustafsson, C, Andersson, C, Olsson, M, Goransson, M. The myxoid/round cell liposarcoma fusion oncogene FUS-DDIT3 and the normal DDIT3 induce a liposarcoma phenotype in transfected human fibrosarcoma cells. Am J Pathol 2006;168:1642–1653.CrossRefGoogle ScholarPubMed
Hisaoka, M, Tsuji, S, Morimitsu, Y, Hashimoto, H, Shimajiri, S, Komiya, S. Detection of TLS/FUS-CHOP fusion transcript in myxoid and round cell liposarcomas by nested reverse transcription-polymerase chain reaction using archival paraffin-embedded tissues. Diagn Mol Pathol 1998;7:96–101.CrossRefGoogle Scholar
Willeke, F, Ridder, R, Mechtersheimer, G, Schwarzback, M, Duwe, A, Weitz, J. Analysis of FUS-CHOP fusion transcripts in different types of soft tissue liposarcoma and their diagnostic implications. Clin Cancer Res 1998;4:1779–1784.Google ScholarPubMed
Panagopoulos, I, Aman, P, Mertens, F, Mandahl, N, Rydholm, A, Bauer, HF. Genomic PCR detects tumor cells in peripheral blood from patients with myxoid liposarcoma. Genes Chromosomes Cancer 1996;17:102–107.3.0.CO;2-9>CrossRefGoogle ScholarPubMed
Dei Tos, AP, Mentzel, T, Fletcher, CD. Primary liposarcoma of the skin: a rare neoplasm with unusual high-grade features. Am J Dermatopathol 1998;20:332–338.CrossRefGoogle ScholarPubMed
Miettinen, M, Enzinger, FM. Epithelioid variant of pleomorphic liposarcoma: A study of 12 cases of a distinctive variant of high-grade liposarcoma. Mod Pathol 1999;12:722–728.Google ScholarPubMed
Hornick, JL, Bosenberg, MW, Mentzel, T, McMenamin, ME, Oliveira, AM, Fletcher, CD. Pleomorphic liposarcoma: clinicopathologic analysis of 57 cases. Am J Surg Pathol 2004;28:1257–1267.CrossRefGoogle ScholarPubMed
Gebhard, S, Coindre, JM, Michels, JJ, Terrier, P, Bertrand, G, Trassard, M. Pleomorphic liposarcoma: clinicopathologic, immunohistochemical, and follow-up analysis of 63 cases: a study from the French Federation of Cancer Centers Sarcoma Group. Am J Surg Pathol 2002;26:601–616.CrossRefGoogle ScholarPubMed
Downes, KA, Goldblum, JR, Montgomery, EA, Fisher, C. Pleomorphic liposarcoma: a clinicopathologic analysis of 19 cases. Mod Pathol 2001;14:179–184.CrossRefGoogle ScholarPubMed
Huang, HY, Antonescu, CR. Epithelioid variant of pleomorphic liposarcoma: a comparative immunohistochemical and ultrastructural analysis of six cases with emphasis on overlapping features with epithelioid malignancies. Ultrastruct Pathol 2002;26:299–308.CrossRefGoogle Scholar
Mertens, F, Fletcher, CD, Dal Cin, P, Wever, I, Mandahl, N, Mitelman, F. Cytogenetic analysis of 46 pleomorphic soft tissue sarcomas and correlation with morphological and clinical features: a report from the CHAMP study group. Genes Chromosomes Cancer 1998;22:16–25.3.0.CO;2-A>CrossRefGoogle Scholar
Idbaih, A, Coindre, JM, Derre, M, Mariani, O, Terrier, P, Ranchere, D. Myxoid malignant fibrous histiocytoma and pleomorphic liposarcoma share very similar genomic imbalance. Lab Invest 2005;85:176–181.CrossRefGoogle Scholar
Rieker, RJ, Joos, S, Bartsch, C, Willeke, F, Schwartzbach, M, Otano-Joos, M. Distinct chromosomal imbalances in pleomorphic and high-grade dedifferentiated liposarcomas. Int J Cancer 2002;99:68–73.CrossRefGoogle ScholarPubMed
Cecco, L, Gariboldi, M, Reid, JF, Lagonigro, MS, Tamborini, E, Albertini, V. Gene expression profile identifies a rare epithelioid variant case of pleomorphic liposarcoma carrying a FUS-CHOP transcript. Histopathology 2005:46:334–341.CrossRefGoogle ScholarPubMed
Enterline, HT, Culberson, JD, Rochlin, DB, Brady, LW. Liposarcoma: A clinical and pathological study of 53 cases. Cancer 1960;13:932–950.3.0.CO;2-S>CrossRefGoogle ScholarPubMed
Enzinger, FM, Winslow, DJ. Liposarcoma: a study of 103 cases. Virchows Arch Anat Pathol [A] 1962;335:367–388.CrossRefGoogle ScholarPubMed
Evans, HL. Liposarcoma: a study of 55 cases with a reassessment of its classification. Am J Surg Pathol 1979;3:507–523.CrossRefGoogle ScholarPubMed
Dei Tos, AP, Pedeutour, F. Atypical lipomatous tumor/well-differentiated liposarcoma. In: Pathology and Genetics of Tumours of Soft Tissue and Bone, Editors Fletcher, CDM, Unni, KK, Lyon, Mertens F., World Health Organization, 2002, pp. 35–37.Google Scholar
Demetri, GD, Fletcher, CD, Mueller, E, Sarraf, P, Naujoks, R, Campbell, N. Induction of solid tumor differentiation by the peroxisome proliferator-activated receptor-gamma ligand troglitazone in patients with liposarcoma. Proc Natl Acad Sci USA 1999;96:3951–3956.CrossRefGoogle ScholarPubMed
Singer, S, Socci, ND, Ambrosini, G, Sambol, E, Decarolis, P, Wu, Y. Gene expression profiling of liposarcoma identifies distinct biological types/subtypes and potential therapeutic targets in well-differentiated and dedifferentiated liposarcoma. Clin Cancer Res 2007;67:6626–6636.Google ScholarPubMed
Müller, CR, Paulsen, EB, Noordhuis, P, Pedeutour, F, Saeter, G, Myklebost, O. Potential for treatment of liposarcomas with the MDM2 antagonist Nutlin-3A. Int J Cancer 2007;121:195–201.CrossRefGoogle ScholarPubMed
Azumi, N, Curtis, J, Kempson, RL. Atypical and malignant neoplasms showing lipomatous differentiation: A study of 111 cases. Am J Surg Pathol 1987;11:161–183.CrossRefGoogle ScholarPubMed
Allen, PW, Strungs, I, MacCormac, LB. Atypical subcutaneous fatty tumors: a review of 37 referred cases. Pathology 1988;30:123–135.CrossRefGoogle Scholar
Evans, HL, Soule, EH, Winkelmann, RK. Atypical lipoma, atypical intramuscular lipoma, and well-differentiated retroperitoneal liposarcoma: a reappraisal of 30 cases formerly classified as well-differentiated liposarcoma. Cancer 1979;43:574–584.3.0.CO;2-7>CrossRefGoogle ScholarPubMed
Evans, HL. Liposarcomas and atypical lipomatous tumors: A study of 66 cases followed for a minimum of 10 years. Surg Pathol 1988;1:41–54.Google Scholar
Kindblom, LG, Angervall, L, Fassina, AS. Atypical lipoma. Acta Pathol Microbiol Immunol Scand [A] 1982;90:27–36.Google ScholarPubMed
Yoshikawa, H, Ueda, T, Mori, S, Araki, N, Myoui, A, Uchida, A. Dediffrentiated liposarcoma of the subcutis. Am J Surg Pathol 1996;20:1525–1530.CrossRefGoogle ScholarPubMed
Austin, RM, Dupree, WB. Liposarcoma of the breast: A clinicopathologic study of 20 cases. Hum Pathol 1986;17:906–913.CrossRefGoogle ScholarPubMed
Powell, CM, Rosen, PP. Adipose differentiation in cystosarcoma phyllodes: A study of 14 cases. Am J Surg Pathol 1994; 18:720–727.CrossRefGoogle ScholarPubMed
Kindblom, LG, Angervall, L, Svendsen, P. Liposarcoma: a clinicopathologic, radiographic, and prognostic study. Acta Pathol Microbiol Scand 1992; 253 (Suppl).Google Scholar
Weiss, SW, Rao, VK. Well-differentiated liposarcoma (atypical lipoma) of deep soft tissue of the extremities, retroperitoneum, and miscellaneous sites: A follow-up study of 92 cases with analysis of the incidence of “dedifferentiation.”Am J Surg Pathol 1992;167:1051–1058.CrossRefGoogle Scholar
Lucas, DR, Nascimento, AG, Sanjay, BK, Rock, MG. Well-differentiated liposarcoma: The Mayo clinic experience with 58 cases. Am J Clin Pathol 1994;102:677–683.CrossRefGoogle Scholar
Montgomery, EA, Fisher, C. Paratesticular liposarcoma: a clinicopathologic study. Am J Surg Pathol 2003;27:40–47.CrossRefGoogle ScholarPubMed
Klimstra, DS, Moran, CA, Perino, G, Koss, MN, Rosai, J. Liposarcoma of the anterior mediastinum and thymus: A clinicopathologic study of 28 cases. Am J Surg Pathol 1995;19: 782–791.CrossRefGoogle ScholarPubMed
Hahn, HP, Fletcher, CD. Primary mediastinal liposarcoma: Clinicopathologic analysis of 24 cases. Am J Surg Pathol 2007;31:1868–1874.CrossRefGoogle ScholarPubMed
Wenig, BM, Weiss, SW, Gnepp, DR. Laryngeal and hypopharyngeal liposarcoma: A clinicopathologic study of 10 cases with a comparison to soft-tissue counterparts. Am J Surg Pathol 1990;14:134–141.CrossRefGoogle ScholarPubMed
Argani, P, Facchetti, F, Inghirami, G, Rosai, J. Lymphocyte-rich well-differentiated liposarcoma: report of nine cases. Am J Surg Pathol 1997:21;884–895.CrossRefGoogle ScholarPubMed
Kraus, MD, Guillou, L, Fletcher, CD. Well-differentiated inflammatory liposarcoma: an uncommon and easily overlooked variant of a common sarcoma. Am J Surg Pathol 1997; 21:518–527.CrossRefGoogle ScholarPubMed
Dei Tos, AP, Mentzel, , Newman, PL, Fletcher, CDM. Spindle cell liposarcoma, a hitherto unrecognized variant of liposarcoma. Am J Surg Pathol 1994;18:913–921.CrossRefGoogle ScholarPubMed
Suster, S.Fisher, C.CD34 in lipomatous tumors. Am J Surg Pathol 1997;195–200.CrossRefGoogle ScholarPubMed
Dei Tos, AP, Doglioni, C, Piccinin, S, Sciot, R, Furlanetto, A, Boiocchi, M. Coordinated expression and amplification of the MDM2, CDK4, and HMGI-C genes in atypical lipomatous tumors. J Pathol 2000;190:531–536.3.0.CO;2-W>CrossRefGoogle Scholar
Pilotti, S, Della Torre, G, Mezzelani, A, Tamborini, E, Azzarelli, A, Sozzi, G. The expression of MDM2/CDK4 gene product in the differential diagnosis of well-differentiated liposarcoma and large deep-seated lipoma. Br J Cancer 2000;82:1271–1275.CrossRefGoogle ScholarPubMed
Binh, MB, Sastre-Garau, X, Guillou, L, Pinieux, G, Terrier, P, Lagace, R. MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data. Am J Surg Pathol 2005;29:1340–1347.CrossRefGoogle ScholarPubMed
Remstein, E, Kurtin, PJ, Nascimento, AG. Sclerosing extramedullary hematopoietic tumor in chronic myeloproliferative disorders. Am J Surg Pathol 2000;24:51–55.CrossRefGoogle ScholarPubMed
Stephenson, CF, Berger, CS, Leong, SP, Davis, JR, Sandberg, AA. Analysis of a giant marker chromosome in well-differentiated liposarcoma using cytogenetics and fluorescence in situ hybridization. Cancer Genet Cytogenet 1992;15:134–138.CrossRefGoogle Scholar
Dal Cin, P, Kools, P, Sciot, R, Wever, I, can Damme, B, Wen, W. Cytogenetic and fluorescence in situ hybriization investigation of ring chromosomes characterizing a specific pathologic subgroup of adipose tissue tumors. Cancer Genet Cytogenet 1993;68:85–90.CrossRefGoogle ScholarPubMed
Pedeutour, F, Suikerbuijk, RF, Forus, A, Gaal, J, Klundert, W, Coindre, JM. Complex composition and co-amplification of SAS and MDM2 in ring and giant rod marker chromosomes in well-differentiated liposarcomas. Genes Chromosomes Cancer 1994;10:85–94.CrossRefGoogle Scholar
Szymanska, J, Virolainen, M, Tarkkanen, M, Wiklund, T, Asko-Seljavaara, S, Tukiainen, E. Overrepresentation of 1q21–23 and 12q13–21 in lipoma-like liposarcomas but not in benign lipomas: A comparative genomic hybridization study. Cancer Genet Cytogenet 1997;99:14–18.CrossRefGoogle Scholar
Rosai, J, Akerman, M, Dal Cin, P, Wever, I, Fletcher, CDM, Mandahl, N. Combined morphologic and karyotypic study of 59 atypical lipomatous tumors: Evaluation of their relationship and differential diagnosis with other adipose tissue tumors. A report of the CHAMP study group. Am J Surg Pathol 1996;20:1182–1189.CrossRefGoogle ScholarPubMed
Henricks, W, Chu, YC, Goldblum, JR, Weiss, SW. Dedifferentiated liposarcoma. A clinicopathological analysis of 155 cases with a proposal for an expanded definition of dedifferentiation. Am J Surg Pathol 1997;21:271–281.CrossRefGoogle ScholarPubMed
Kransdorf, MJ, Meis, JM, Jelinek, JS. Dedifferentiated liposarcoma of the extremities: imaging finding in four patients. AJR Am J Roentgenol 1993;161:127–130.CrossRefGoogle Scholar
Hisaoka, M, Morimitsu, Y, Hashimoto, H, Ishida, T, Mukai, H, Satoh, H. Retroperitoneal liposarcoma with combined well-differentiated and myxoid malignant fibrous histiocytoma-like myxoid areas. Am J Surg Pathol 1999; 23:1480–1492.CrossRefGoogle ScholarPubMed
Coindre, JM, Hostein, I, Maire, G, Derre, J, Guillou, LLeroux, A. Inflammatory malignant fibrous histicytomas and dedifferentiated liposarcomas: histologic review, genetic profile, and MDM2 and CDK4 status favor a single entity. J Pathol 2004:128–1523–1529.Google Scholar
Coindre, JM, Mariani, O, Chibon, F, Mairal, A, Saint Aubain Somerhausen, N, Favre-Guillevin, E. Most malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcomas: a review of 25 cases initially diagnosed as malignant fibrous histiocytomas. Mod Pathol 2003;16:256–262.CrossRefGoogle ScholarPubMed
McCormick, D, Mentzel, T, Beham, A, Fletcher, CDM. Dedifferentiated liposarcoma: Clinicopathologic analysis of 32 cases suggesting a better prognostic subgroup among pleomorphic sarcomas. Am J Surg Pathol 1994;18:1213–1223.CrossRefGoogle ScholarPubMed
Elgar, F, Goldblum, JR. Well-differentiated liposarcoma of the retroperitoneum: a clinicopathologic analysis of 20 cases, with particular attention to the extent of low-grade dedifferentiation. Mod Pathol 1997;10:113–120.Google ScholarPubMed
Hasegawa, T, Seki, K, Hasegawa, F, Matsuno, Y, Shimoda, T, Horose, T. Dedifferentiated liposarcoma of retroperitoneum and mesentery: Varied growth patterns and histological grades - A clinicopathologic study of 32 cases. Hum Pathol 2000;31:717–727.CrossRefGoogle ScholarPubMed
Nascimento, AG, Kurtin, PJ, Guillou, L, Fletcher, CD. Dedifferentiated liposarcoma: a report of nine cases with a peculiar neurallike whorling pattern associated with metaplastic bone formation. Am J Surg Pathol 1998;22:945–955.CrossRefGoogle ScholarPubMed
Fanburg-Smith, J, Miettinen, M. Liposarcoma with meningothelial whorls: An analysis of 17 cases of a distinctive histologic pattern associated with dedifferentiated liposarcoma. Histopathology 1998;33:414–424.CrossRefGoogle Scholar
Nicolas, M, Moran, CA, Suster, S. Pulmonary metastasis from liposarcoma: a clinicopathologic and immunohistochemical study of 24 cases. Am J Clin Pathol 2005;123:265–275.CrossRefGoogle ScholarPubMed
Huang, HY, Brennan, MF, Singer, S, Antonescu, CR. Distant metastases in retroperitoneal dedifferentiated liposarcoma is rare and rapidly fatal: a clinicopathologic study with emphasis on the low-grade myxofibrosarcomatous patten as an early sign of differentiation. Mod Pathol 2005;18:976–984.CrossRefGoogle Scholar
Tallini, G, Erlandson, RA, Brennan, MF, Woodruff, JM. Divergent myosarcomatous differentiation in retroperitoneal liposarcoma. Am J Surg Pathol 1993;17:546–556.CrossRefGoogle ScholarPubMed
Evans, HL, Khurana, KK, Kemp, BL, Ayala, AG. Heterologous elements in the dedifferentiated component of dedifferentiated liposarcoma. Am J Surg Pathol 1994;18:1150–1157.CrossRefGoogle ScholarPubMed
Suster, S, Wong, TY, Moran, CA. Sarcomas with combined features of liposarcoma and leiomyosarcoma: Study of two cases of an unusual soft tissue tumor showing dual lineage differentiation. Am J Surg Pathol 1993;17:905–911.CrossRefGoogle ScholarPubMed
Folpe, ALWiess, SW. Lipoleiomyosarcoma (well-differentiated liposarcoma with leiomyosarcomatous differentiation): a clinicopathologic study of nine cases including one with dedifferentiation. Am J Surg Pathol 2002;26: 742–749.CrossRefGoogle ScholarPubMed
Binh, MBN, Guillou, L, Hostein, I, Chateau, MC, Collin, F, Aurias, A. Dedifferentiated liposarcomas with divergent myosarcomatous differentiation developed in the internal trunk: A study of 27 cases and comparison to conventional dedifferentiated liposarcomas and leiomyosarcomas. Am J Surg Pathol 2007;31:1557–1566.CrossRefGoogle ScholarPubMed
Macarenco, RS, Erickson-Johnson, M, Wang, X, Jenkins, RB, Nascimentoa, AG, Oliveira, AM. Cytogenetic and molecular cytogenetic findings in dedifferentiated liposarcoma with neural-like whirling pattern and metaplastic bone formation. Cancer Genet Cytogenet 2007;172:147–150.CrossRefGoogle Scholar
Nishio, J, Iwasaki, H, Ishiguro, M, Ohjimi, Y, Fujita, C, Ikegami, H. Establishment of a novel human dedifferentiated liposarcoma cell line, FU-DDLS-1: conventional and molecular cytogenetic characterization. Int J Oncol 2003;22:535–542.Google ScholarPubMed
Takahira, T, Oda, Y, Tamiya, S, Yamamoto, H, Kobayashi, C, Izumi, T. Alterations of the RB1 gene in dedifferentiated liposarcoma. Mod Pathol 2005;18:1461–1470.CrossRefGoogle ScholarPubMed
Fritz, B, Schubert, F, Wrobel, G, Schwaenen, C, Wessendorf, S, Nessling, M. Microarray-based copy number and expression profiling in dedifferentiated and pleomorphic liposarcomas. Cancer Res 2002;62:2993–2998.Google Scholar
Kilpatrick, SE, Doyon, J, Choong, PF, Sim, FH, Nascimento, AG. The clinicopathologic spectrum of myxoid and round cell liposarcoma: A study of 95 cases. Cancer 1996;77:1450–1458.3.0.CO;2-G>CrossRefGoogle ScholarPubMed
Shmookler, BM, Enzinger, FM. Liposarcomas occurring in children: an analysis of 17 cases and review of the literature. Cancer 1983;53:567–574.3.0.CO;2-4>CrossRefGoogle Scholar
Miller, GG, Yanchar, NL, Magee, JF, Blair, GK. Lipoblastoma and liposarcoma in children: an analysis of 9 cases and a review of the literature. Can J Surg 1998;41:455–458.Google Scholar
Quaglia, MP, Spiro, SA, Ghavimi, F, Hajdu, SI, Meyers, P, Exelby, PR. Liposarcoma in patients younger than or equal to 22 years of age. Cancer 1993;72:3114–3119.3.0.CO;2-I>CrossRefGoogle ScholarPubMed
Smith, TA, Easley, KA, Goldblum, JR. Myxoid/round cell liposarcoma of the extremities: A clinicopathologic study of 29 cases with particular attention to extent of round cell liposarcoma. Am J Surg Pathol 1996;20:171–180.CrossRefGoogle ScholarPubMed
Antonescu, CR, Elahi, A, Healey, JH, Brennan, MF, Lui, MY, Lewis, J. Monoclonality of multifocal myxoid liposarcoma: confirmation by analysis of TLS-CHOP or EWS-CHOP rearrangements. Clin Cancer Res 2000;6:2788–2793.Google ScholarPubMed
Spillane, AJ, Fisher, C, Thomas, JM. Myxoid liposarcoma – the frequency and the natural history of nonpulmonary soft tissue metastases. Ann Surg Oncol 1999;6:389–394.CrossRefGoogle ScholarPubMed
Fukuda, T, Oshiro, Y, Yamamoto, I, Tsuneyoshi, M. Long-term follow-up of pure myxoid liposarcomas with special reference to local recurrence and progression to round cell lesions. Pathol Int 1999;49:710–715.CrossRefGoogle ScholarPubMed
Patel, SR, Burgess, MA, Plager, C, Papadopoulos, NE, Linke, KA, Benjamin, RS. Myxoid liposarcoma: Experience with chemotherapy. Cancer 1994;74:1265–1269.3.0.CO;2-X>CrossRefGoogle ScholarPubMed
Siebert, JD, Williams, RP, Pulitzer, DR. Myxoid liposarcoma with cartilaginous differentiation. Mod Pathol 1996;9:249–252.Google ScholarPubMed
Engstrom, K, Bergh, P, Cederlund, CG, Hultborn, R, Willen, H, Aman, P. Irradiation of myxoid/round cell liposarcoma induces volume reduction and lipoma-like morphology. Acta Oncol 2007;46:838–845.CrossRefGoogle ScholarPubMed
DeiTos, AP, Piccinin, S, Doglioni, C, Vukosavljevic, T, Mentzel, T, Boiocchi, M. Molecular aberrations of the G1-S checkpoint in myxoid and round cell liposarcoma. Am J Pathol 1997;151:1531–1539.Google Scholar
Oliveira, AM, Nascimento, AG, Okuno, SH, Lloyd, RV. P27 (kip1) protein expression correlates with survival in myxoid and round-cell liposarcoma. J Clin Oncol 2000;18:2888–2893.CrossRefGoogle ScholarPubMed
Oda, Y, Yamamoto, H, Takahira, T, Kobayashi, C, Kawaguchi, K, Tateishi, N. Frequent alteration of p16(INK4a)/p14(ARF) and p53 pathways in the round cell component of myxoid/round cell liposarcoma: p53 gene alterations and reduced p14 (ARF) expression both correlate with poor prognosis. J Pathol 2005;207:410–421.CrossRefGoogle ScholarPubMed
Crozat, A, Aman, P, Mandahl, N, Ron, D. Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature 1993;363:640–644.CrossRefGoogle ScholarPubMed
Panagopoulos, I, Mandahl, N, Ron, D, Hoglund, M, Nilbert, M, Mertens, F. Characterization of the CHOP breakpoints and fusion transcripts in myxoid liposarcomas with the 12;16 translocation. Cancer Res 1994;54:6500–6503.Google ScholarPubMed
Gibas, Z, Miettinen, M, Limon, J, Nedoszytko, B, Mrozek, K, Roszkiewicz, et al . Cytogenetic and immunohistochemical profile of myxoid liposarcoma. Am J Clin Pathol 1995; 103:20–26.CrossRefGoogle ScholarPubMed
Knight, JC, Renwick, PJ, Dal Cin, PD, Berghe, H, Fletcher, CD. Translocation t(12;16)(q13;p11) in myxoid liposarcoma and round cell liposarcoma: molecular and cytogenetic analysis. Cancer Res 1995;55:24–27.Google Scholar
Tallini, G, Akerman, M, Dal Cin, P, Wewer, I, Fletcher, CD, Mandahl, N. Combined morphologic and karyotypic study of 28 myxoid liposarcomas: Implications for a revised morphological typing (a report from the CHAMP-group). Am J Surg Pathol 1996;20:1047–1055.CrossRefGoogle Scholar
Panagopoulos, I, Mandahl, N, Mitelman, F, Aman, P. Two distinct FUS breakpoint clusters in myxoid liposarcoma and acute myeloid leukemia with the translocations t(12;16) and t(16;21). Oncogene 1995;11:1133–1137.Google Scholar
Panagopoulos, I, Hoglund, M, Mertens, F, Mandahl, N, Mitelman, F, Aman, P. Fusion of the EWS and CHOP genes in myxoid liposarcoma. Oncogene 1996;12:489–494.Google ScholarPubMed
Dal Cin, P, Sciot, R, Panagopuolos, I, Aman, P, Samson, I, Mandahl, N. Additional evidence of a variant translocation t(12;22) with EWS/CHOP fusion in myxoid liposarcoma: clinicopathological features. J Pathol 1997;182: 437–441.3.0.CO;2-X>CrossRefGoogle Scholar
Panagopoulos, I, Lassen, C, Isaksson, M, Mitelman, F, Mandahl, N, Aman, P. Characteristic sequence motifs at the breakpoints of the hybrid genes FUS/CHOP, EWS/CHOP and FUS/ERG in myxoid liposarcoma and acute myeloid leukemia. Oncogene 1997;15:1357–1362.CrossRefGoogle ScholarPubMed
Kuroda, M, Ishida, T, Horiuchi, H, Kida, N, Uozaki, H, Takeuchi, H. Chimeric TLS/FUS-CHOP gene expression and the heterogeneity of its junction in human myxoid and round cell liposarcoma. Am J Pathol 1995;147:1221–1227.Google ScholarPubMed
Kuroda, M, Wang, X, Sok, J, Yin, Y, Chung, P, Giannotti, JW. Induction of a secreted protein by the myxoid liposarcoma oncogene. Proc Natl Acad Sci (USA) 1999;96:5025–5030.CrossRefGoogle ScholarPubMed
Adelmant, G, Gilbert, JD, Freytag, SO. Human translocation liposarcoma-CCAAT/enhancer binding protein (C/EBP) homologous protein (TLS/CHOP) oncoprotein prevents adipocyte differentiation by directly interfering with C/EBPbeta function. J Biol Chem 1998;273:15574–15581.CrossRefGoogle Scholar
Engstrom, K, Willen, H, Kabjorn-Gustafsson, C, Andersson, C, Olsson, M, Goransson, M. The myxoid/round cell liposarcoma fusion oncogene FUS-DDIT3 and the normal DDIT3 induce a liposarcoma phenotype in transfected human fibrosarcoma cells. Am J Pathol 2006;168:1642–1653.CrossRefGoogle ScholarPubMed
Hisaoka, M, Tsuji, S, Morimitsu, Y, Hashimoto, H, Shimajiri, S, Komiya, S. Detection of TLS/FUS-CHOP fusion transcript in myxoid and round cell liposarcomas by nested reverse transcription-polymerase chain reaction using archival paraffin-embedded tissues. Diagn Mol Pathol 1998;7:96–101.CrossRefGoogle Scholar
Willeke, F, Ridder, R, Mechtersheimer, G, Schwarzback, M, Duwe, A, Weitz, J. Analysis of FUS-CHOP fusion transcripts in different types of soft tissue liposarcoma and their diagnostic implications. Clin Cancer Res 1998;4:1779–1784.Google ScholarPubMed
Panagopoulos, I, Aman, P, Mertens, F, Mandahl, N, Rydholm, A, Bauer, HF. Genomic PCR detects tumor cells in peripheral blood from patients with myxoid liposarcoma. Genes Chromosomes Cancer 1996;17:102–107.3.0.CO;2-9>CrossRefGoogle ScholarPubMed
Dei Tos, AP, Mentzel, T, Fletcher, CD. Primary liposarcoma of the skin: a rare neoplasm with unusual high-grade features. Am J Dermatopathol 1998;20:332–338.CrossRefGoogle ScholarPubMed
Miettinen, M, Enzinger, FM. Epithelioid variant of pleomorphic liposarcoma: A study of 12 cases of a distinctive variant of high-grade liposarcoma. Mod Pathol 1999;12:722–728.Google ScholarPubMed
Hornick, JL, Bosenberg, MW, Mentzel, T, McMenamin, ME, Oliveira, AM, Fletcher, CD. Pleomorphic liposarcoma: clinicopathologic analysis of 57 cases. Am J Surg Pathol 2004;28:1257–1267.CrossRefGoogle ScholarPubMed
Gebhard, S, Coindre, JM, Michels, JJ, Terrier, P, Bertrand, G, Trassard, M. Pleomorphic liposarcoma: clinicopathologic, immunohistochemical, and follow-up analysis of 63 cases: a study from the French Federation of Cancer Centers Sarcoma Group. Am J Surg Pathol 2002;26:601–616.CrossRefGoogle ScholarPubMed
Downes, KA, Goldblum, JR, Montgomery, EA, Fisher, C. Pleomorphic liposarcoma: a clinicopathologic analysis of 19 cases. Mod Pathol 2001;14:179–184.CrossRefGoogle ScholarPubMed
Huang, HY, Antonescu, CR. Epithelioid variant of pleomorphic liposarcoma: a comparative immunohistochemical and ultrastructural analysis of six cases with emphasis on overlapping features with epithelioid malignancies. Ultrastruct Pathol 2002;26:299–308.CrossRefGoogle Scholar
Mertens, F, Fletcher, CD, Dal Cin, P, Wever, I, Mandahl, N, Mitelman, F. Cytogenetic analysis of 46 pleomorphic soft tissue sarcomas and correlation with morphological and clinical features: a report from the CHAMP study group. Genes Chromosomes Cancer 1998;22:16–25.3.0.CO;2-A>CrossRefGoogle Scholar
Idbaih, A, Coindre, JM, Derre, M, Mariani, O, Terrier, P, Ranchere, D. Myxoid malignant fibrous histiocytoma and pleomorphic liposarcoma share very similar genomic imbalance. Lab Invest 2005;85:176–181.CrossRefGoogle Scholar
Rieker, RJ, Joos, S, Bartsch, C, Willeke, F, Schwartzbach, M, Otano-Joos, M. Distinct chromosomal imbalances in pleomorphic and high-grade dedifferentiated liposarcomas. Int J Cancer 2002;99:68–73.CrossRefGoogle ScholarPubMed
Cecco, L, Gariboldi, M, Reid, JF, Lagonigro, MS, Tamborini, E, Albertini, V. Gene expression profile identifies a rare epithelioid variant case of pleomorphic liposarcoma carrying a FUS-CHOP transcript. Histopathology 2005:46:334–341.CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×