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Chapter 9 - Attention Deficit Hyperactivity Disorder in Adults

From Research to Clinical Practice

Published online by Cambridge University Press:  01 February 2024

By
Philip Asherson ,
Judit Balazs ,
Istvan Bitter ,
Pieter-Jan Carpentier ,
Rafał Jaeschke ,
Pavel Mohr ,
Josep Antoni Ramos-Quiroga ,
Pietro De Rossi ,
Bengi Semerci  and
Sandra Kooij
Edited by
Andrea Fiorillo ,
Peter Falkai  and
Philip Gorwood
Andrea Fiorillo
Affiliation:
University of Campania “L. Vanvitelli”, Naples
Peter Falkai
Affiliation:
Ludwig-Maximilians-Universität München
Philip Gorwood
Affiliation:
Sainte-Anne Hospital, Paris
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Summary

Attention deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder that persists into adulthood. We provide an overview of prevalence, diagnosis, and treatment. Future directions highlight key areas of progress. ADHD is not always an early childhood onset disorder; it may emerge as an impairing condition during the adolescent years. Transition from child to adult services is poor and greater efforts are needed to ensure effective treatment during this critical stage. There are sex differences in the expression of ADHD. Related to this, the diagnosis of ADHD is often missed in girls but is increasingly recognized in adult life. The impact of emotional instability as a core feature of ADHD on mental health is widely recognized. It is still the case that ADHD is often misdiagnosed for other common mental health conditions, and greater awareness of ADHD is needed among health care professionals. Prominent comorbidities include substance use and sleep problems. Finally, we consider the cognitive and neural processes that explain persistence of ADHD. The balance of default mode to task positive network activity may lead to core symptoms such as spontaneous mind wandering, and the role of saliency on task performance.

Keywords

neurodevelopmentattention deficit hyperactivity disorderadult mental healthstimulantscomorbidityacademic failuresubstance use disorderssleep disordersage of onset
Type
Chapter
Information
Mental Health Research and Practice
From Evidence to Experience
 , pp. 135 - 157
Publisher: Cambridge University Press
Print publication year: 2024

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References

American Psychiatric Association (APA). Diagnostic and Statistical Manual of Mental Disorders Fifth Edition (DSM-5). Arlington, TX: American Psychiatric Association; (2013).Google Scholar
Asherson, P, Buitelaar, J, Faraone, SV, Rohde, LA. Adult attention-deficit hyperactivity disorder: key conceptual issues. Lancet Psychiatry. 2016;3(6):568–78.CrossRefGoogle ScholarPubMed
Kooij, JJS, Bijlenga, D, Salerno, L, et al. Updated European Consensus Statement on diagnosis and treatment of adult ADHD. European Psychiatry. 2019;56:14–34.CrossRefGoogle ScholarPubMed
Kooij, SJ, Bejerot, S, Blackwell, A, et al. European consensus statement on diagnosis and treatment of adult ADHD: The European Network Adult ADHD. BMC Psychiatry. 2010;10:67.CrossRefGoogle ScholarPubMed
Fayyad, J, Sampson, NA, Hwang, I, et al. The descriptive epidemiology of DSM-IV Adult ADHD in the World Health Organization World Mental Health Surveys. Attention Deficit and Hyperactivity Disorders. 2017;9(1):47–65.CrossRefGoogle ScholarPubMed
Polanczyk, G, de Lima, MS, Horta, BL, Biederman, J, Rohde, LA . The worldwide prevalence of ADHD: a systematic review and metaregression analysis. The American Journal of Psychiatry. 2007;164(6):942–8.CrossRefGoogle ScholarPubMed
Fayyad, J, De Graaf, R, Kessler, R, et al. Cross-national prevalence and correlates of adult attention-deficit hyperactivity disorder. British Journal of Psychiatry: The Journal of Mental Science. 2007;190:402–9.CrossRefGoogle ScholarPubMed
Simon, V, Czobor, P, Balint, S, Meszaros, A, Bitter, I. Prevalence and correlates of adult attention-deficit hyperactivity disorder: meta-analysis. British Journal of Psychiatry: The Journal of Mental Science. 2009;194(3):204–11.CrossRefGoogle ScholarPubMed
Hong, SB, Dwyer, D, Kim, JW, et al. Subthreshold attention-deficit/hyperactivity disorder is associated with functional impairments across domains: a comprehensive analysis in a large-scale community study. European Child & Adolescent Psychiatry. 2014;23(8):627–36.CrossRefGoogle Scholar
Michielsen, M, Semeijn, E, Comijs, HC, et al. Prevalence of attention-deficit hyperactivity disorder in older adults in The Netherlands. British Journal of Psychiatry: The Journal of Mental Science. 2012;201(4):298–305.CrossRefGoogle ScholarPubMed
Dalsgaard, S, Ostergaard, SD, Leckman, JF, et al. Mortality in children, adolescents, and adults with attention deficit hyperactivity disorder: a nationwide cohort study. Lancet. 2015;385(9983):2190–6.CrossRefGoogle ScholarPubMed
Faraone, SV, Biederman, J, Mick, E. The age-dependent decline of attention deficit hyperactivity disorder: a meta-analysis of follow-up studies. Psychological Medicine. 2006;36(2):159–65.CrossRefGoogle ScholarPubMed
Lara, C, Fayyad, J, de Graaf, R, et al. Childhood predictors of adult attention-deficit/hyperactivity disorder: results from the World Health Organization World Mental Health Survey Initiative. Biological Psychiatry. 2009;65(1):46–54.CrossRefGoogle ScholarPubMed
Cheung, CH, Rijdijk, F, McLoughlin, G, et al. Childhood predictors of adolescent and young adult outcome in ADHD. Journal of Psychiatric Research. 2015;62:92–100.CrossRefGoogle Scholar
Van Lieshout, M, Luman, M, Twisk, JWR, et al. A six-year follow up study of a large European cohort of children with attention-deficit/hyperactivity disorder combined subtype: outcomes in late adolescence and young adulthood. European Child and Adolescent Psychiatry. 2016;25(9):1007–17.CrossRefGoogle Scholar
Barkley, R, Murphy, KR, Fischer, M. ADHD in adults: what the science says. New York: Guilford Press; 2007.Google Scholar
Moffitt, TE, Houts, R, Asherson, P, et al. Is Adult ADHD a childhood-onset neurodevelopmental disorder? evidence from a four-decade longitudinal cohort study. American Journal of Psychiatry. 2015;172(10):967–77.CrossRefGoogle ScholarPubMed
NICE. Diagnosis and management of ADHD in children, young people and adults. London: The British Psychological Society and The Royal College of Psychiatrists; 2018.Google Scholar
NICE. Attention deficit hyperactivity disorder: evidence update 45: National Institute of Health and Clinical Excellence; 2013. file:///C:/Users/Philip%20Asherson/Downloads/Attention+deficit+hyperactivity+disorder+Evidence+Update+July+2013.pdf.Google Scholar
Kooij, JJ, Francken, MH, Bron, TI. Diagnostisch Interview Voor ADHD 2019. https://www.divacenter.eu.Google Scholar
Arns, M, Loo, SK, Sterman, MB, et al. Editorial perspective: How should child psychologists and psychiatrists interpret FDA device approval? Caveat emptor. Journal of Child Psychology And Psychiatry. 2016;57(5):656–8.CrossRefGoogle ScholarPubMed
Faraone, SV, Asherson, P, Banaschewski, T, et al. Attention-deficit/hyperactivity disorder. Nature Reviews Disease Primers. 2015;1:15020.CrossRefGoogle ScholarPubMed
Thapar, A. Discoveries on the genetics of ADHD in the 21st century: New findings and their implications. American Journal of Psychiatry. 2018;175(10):943–50.CrossRefGoogle ScholarPubMed
Middeldorp, CM, Hammerschlag, AR, Ouwens, KG, et al. A genome-wide association meta-analysis of attention-deficit/hyperactivity disorder symptoms in population-based pediatric cohorts. Journal of the American Academy of Child and Adolescent Psychiatry. 2016;55(10):896–905, e6.CrossRefGoogle ScholarPubMed
NICE. Attention Deficit Hyperactivity Disorder: The NICE guideline on diagnosis and management of ADHD in children, young people and adults. The British Psychological Society and The Royal College of Psychiatrists; 2008.Google Scholar
Adler, LA, Faraone, SV, Spencer, TJ, et al. The reliability and validity of self- and investigator ratings of ADHD in adults. Journal of Attention Disorders. 2008;11(6):711–9.CrossRefGoogle ScholarPubMed
Erhardt, D, Epstein, J, Conners, CK, Parker, J, Sitarenios, G. Self-ratings of ADHD symptoms in adults: II. Reliability, validity, and diagnostic sensitivity. Journal of Attention Disorders. 1999;3(3):153–8.CrossRefGoogle Scholar
Kooij, JJ, Buitelaar, JK, van den Oord, EJ, et al. Internal and external validity of attention-deficit hyperactivity disorder in a population-based sample of adults. Psychological Medicine. 2005;35(6):817–27.Google Scholar
Semeijn, EJ, Michielsen, M, Comijs, HC, et al. Criterion validity of an Attention Deficit Hyperactivity Disorder (ADHD) screening list for screening ADHD in older adults aged 60–94 years. The American Journal of Geriatric Psychiatry: Official Journal of the American Association for Geriatric Psychiatry. 2013;21(7):631–5.CrossRefGoogle ScholarPubMed
Asherson, P, Agnew-Blais, J. Annual research review: Does late-onset attention-deficit/hyperactivity disorder exist? Journal of Child Psychology And Psychiatry. 2019;60(4):333–52.CrossRefGoogle ScholarPubMed
Franke, B, Faraone, SV, Asherson, P, et al. The genetics of attention deficit/hyperactivity disorder in adults, a review. Molecular Psychiatry. 2012;17(10):960–87.CrossRefGoogle ScholarPubMed
Larsson, H, Chang, Z, D’Onofrio, BM, Lichtenstein, P. The heritability of clinically diagnosed attention deficit hyperactivity disorder across the lifespan. Psychological Medicine. 2014;44(10):2223–9.CrossRefGoogle ScholarPubMed
Rovira, P, Demontis, D, Sanchez-Mora, C, et al. Shared genetic background between children and adults with attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2020;45:1617–26.CrossRefGoogle ScholarPubMed
Cubillo, A, Halari, R, Ecker, C, et al. Reduced activation and inter-regional functional connectivity of fronto-striatal networks in adults with childhood Attention-Deficit Hyperactivity Disorder (ADHD) and persisting symptoms during tasks of motor inhibition and cognitive switching. Journal of Psychiatric Research. 2010;44(10):629–39.CrossRefGoogle ScholarPubMed
Cubillo, A, Halari, R, Smith, A, Taylor, E, Rubia, K. A review of fronto-striatal and fronto-cortical brain abnormalities in children and adults with Attention Deficit Hyperactivity Disorder (ADHD) and new evidence for dysfunction in adults with ADHD during motivation and attention. Cortex; A Journal Devoted to the Study of the Nervous System and Behavior. 2012;48(2):194–215.CrossRefGoogle ScholarPubMed
Hoogman, M, Muetzel, R, Guimaraes, JP, et al. Brain imaging of the cortex in ADHD: A coordinated analysis of large-scale clinical and population-based samples. American Journal of Psychiatry. 2019;176(7):531–42.CrossRefGoogle ScholarPubMed
Posner, J, Park, C, Wang, Z. Connecting the dots: A review of resting connectivity MRI studies in attention-deficit/hyperactivity disorder. Neuropsychology Review. 2014;24(1):3–15.CrossRefGoogle ScholarPubMed
Cortese, S, Adamo, N, Del Giovane, C, et al. Comparative efficacy and tolerability of medications for attention-deficit hyperactivity disorder in children, adolescents, and adults: a systematic review and network meta-analysis. Lancet Psychiatry. 2018;5(9):727–38.Google ScholarPubMed
Alliance CAR. CADDRA Canadian ADHD Practice Guidelines 2011. www.caddra.ca.Google Scholar
German Society for Psychiatry and Psychotherapy PaND. ADHD in children, adolescents and adults. www.awmf.org/leitlinien/detail/ll/028-045.html2017.Google Scholar
Grupo de trabajo de la Guía de Práctica Clínica sobre las Intervenciones Terapéuticas en el Trastorno por Déficit de Atención con Hiperactividad (TDAH). Guía de Práctica Clínica sobre las Intervenciones Terapéuticas en el Trastorno por Déficit de Atención con Hiperactividad (TDAH). In: Ministerio de Sanidad SSeIIAdCdlSI (Ed.): Guías de Práctica Clínica en el SNS; 2017.Google Scholar
Philipsen, A, Jans, T, Graf, E, et al. Effects of group psychotherapy, individual counseling, methylphenidate, and placebo in the treatment of adult attention-deficit/hyperactivity disorder: A randomized clinical trial. JAMA Psychiatry. 2015;72(12):1199–210.CrossRefGoogle ScholarPubMed
Philipsen, A. Psychotherapy in adult attention deficit hyperactivity disorder: Implications for treatment and research. Expert Review of Neurotherapeutics. 2012;12(10):1217–25.CrossRefGoogle Scholar
Sonuga-Barke, EJ, Brandeis, D, Cortese, S, et al. Nonpharmacological interventions for ADHD: Systematic review and meta-analyses of randomized controlled trials of dietary and psychological treatments. The American Journal of Psychiatry. 2013;170(3):275–89.CrossRefGoogle ScholarPubMed
Daley, D, Van Der Oord, S, Ferrin, M, et al. Practitioner review: Current best practice in the use of parent training and other behavioural interventions in the treatment of children and adolescents with attention deficit hyperactivity disorder. Journal of Child Psychology and Psychiatry. 2018;59(9):932–47.CrossRefGoogle ScholarPubMed
Chang, Z, Ghirardi, L, Quinn, PD, et al. Risks and benefits of attention-deficit/hyperactivity disorder medication on behavioral and neuropsychiatric outcomes: A qualitative review of pharmacoepidemiology studies using linked prescription databases. Biological Psychiatry. 2019;86(5):335–43.CrossRefGoogle ScholarPubMed
Lichtenstein, P, Halldner, L, Zetterqvist, J, et al. Medication for attention deficit-hyperactivity disorder and criminality. The New England Journal of Medicine. 2012;367(21):2006–14.CrossRefGoogle ScholarPubMed
Chang, Z, Lichtenstein, P, Langstrom, N, Larsson, H, Fazel, S. Association between prescription of major psychotropic medications and violent reoffending after prison release. JAMA: The Journal of the American Medical Association. 2016;316(17):1798–807.CrossRefGoogle ScholarPubMed
Chang, Z, Lichtenstein, P, D’Onofrio, BM, Sjolander, A, Larsson, H. Serious transport accidents in adults with attention-deficit/hyperactivity disorder and the effect of medication: a population-based study. JAMA Psychiatry. 2014;71(3):319–25.CrossRefGoogle ScholarPubMed
Chang, Z, D’Onofrio, BM, Quinn, PD, Lichtenstein, P, Larsson, H. Medication for attention-deficit/hyperactivity disorder and risk for depression: A nationwide longitudinal cohort study. Biological Psychiatry. 2016;80(12):916–22.CrossRefGoogle ScholarPubMed
Chang, Z, Quinn, PD, O’Reilly, L, et al. Medication for attention-deficit/hyperactivity disorder and risk for suicide attempts. Biological Psychiatry. 2019;88(6):452–8.Google ScholarPubMed
Chang, Z, Lichtenstein, P, Halldner, L, et al. Stimulant ADHD medication and risk for substance abuse. Journal of Child Psychology and Psychiatry, and Allied Disciplines. 2014;55(8):878–85.Google ScholarPubMed
Viktorin, A, Ryden, E, Thase, ME, et al. The risk of treatment-emergent mania with methylphenidate in bipolar disorder. The American Journal of Psychiatry. 2017;174(4):341–8.CrossRefGoogle ScholarPubMed
Hollis, C, Chen, Q, Chang, Z, et al. Methylphenidate and the risk of psychosis in adolescents and young adults: A population-based cohort study. Lancet Psychiatry. 2019;6(8):651–8.CrossRefGoogle Scholar
Martin, J, Walters, RK, Demontis, D, et al. A genetic investigation of sex bias in the prevalence of attention-deficit/hyperactivity disorder. Biological Psychiatry. 2018;83(12):1044–53.CrossRefGoogle ScholarPubMed
Larsson, H, Lichtenstein, P, Larsson, JO. Genetic contributions to the development of ADHD subtypes from childhood to adolescence. Journal of the American Academy of Child and Adolescent Psychiatry. 2006;45(8):973–81.Google Scholar
Martin, J, Taylor, MJ, Rydell, M, et al. Sex-specific manifestation of genetic risk for attention deficit hyperactivity disorder in the general population. Journal of Child Psychology and Psychiatry, and Allied Disciplines. 2018;59(8):908–16.Google ScholarPubMed
Hwang, WJ, Lee, TY, Kim, NS, Kwon, JS. The role of estrogen receptors and their signaling across psychiatric disorders. International Journal of Molecular Sciences. 2020;22(1):373.CrossRefGoogle ScholarPubMed
Epperson, CN, Shanmugan, S, Kim, DR, et al. New onset executive function difficulties at menopause: A possible role for lisdexamfetamine. Psychopharmacology. 2015;232(16):3091–100.CrossRefGoogle ScholarPubMed
Mowlem, FD, Rosenqvist, MA, Martin, J, et al. Sex differences in predicting ADHD clinical diagnosis and pharmacological treatment. European Child and Adolescent Psychiatry. 2019;28(4):481–9.CrossRefGoogle ScholarPubMed
Mowlem, F, Agnew-Blais, J, Taylor, E, Asherson, P. Do different factors influence whether girls versus boys meet ADHD diagnostic criteria? Sex differences among children with high ADHD symptoms. Psychiatry Research. 2019;272:765–73.CrossRefGoogle ScholarPubMed
Quinn, PO, Madhoo, M. A review of attention-deficit/hyperactivity disorder in women and girls: Uncovering this hidden diagnosis. The Primary Care Companion to CNS Disorders. 2014;16(3).Google ScholarPubMed
Asherson, P, Chen, W, Craddock, B, Taylor, E. Adult attention-deficit hyperactivity disorder: Recognition and treatment in general adult psychiatry. British Journal of Psychiatry. 2007;190:4–5.CrossRefGoogle ScholarPubMed
Roy, A, Hechtman, L, Arnold, LE, et al. Childhood factors affecting persistence and desistence of attention-deficit/hyperactivity disorder symptoms in adulthood: results from the MTA. Journal of the American Academy of Child and Adolescent Psychiatry. 2016;55(11):937–44 e4.Google ScholarPubMed
Gillberg, C. ADHD and DAMP: A General Health Perspective. Child and Adolescent Mental Health. 2003;8(3):106–13.CrossRefGoogle ScholarPubMed
Wong, IC, Asherson, P, Bilbow, A, et al. Cessation of attention deficit hyperactivity disorder drugs in the young (CADDY): A pharmacoepidemiological and qualitative study. Health Technology Assessment. 2009;13(50):iii–iv, ix–xi, 1–120.Google Scholar
Farahbakhshian, S, Ayyagari, R, Barczak, DS, et al. Disruption of pharmacotherapy during the transition from adolescence to early adulthood in patients with attention-deficit/hyperactivity disorder: A claims database analysis across the USA. CNS Drugs. 2021;35(5):575–89.CrossRefGoogle ScholarPubMed
Singh, I, Kendall, T, Taylor, C, et al. Young people’s experience of ADHD and stimulant medication: A qualitative study for the NICE guideline. Child and Adolescent Mental Health. 2010;15(4):186–92.CrossRefGoogle ScholarPubMed
McNicholas, F, Adamson, M, McNamara, N, et al. Who is in the transition gap? Transition from CAMHS to AMHS in the Republic of Ireland. Irish Journal of Psychological Medicine. 2015;32(1):61–9.CrossRefGoogle ScholarPubMed
Swift, KD, Sayal, K, Hollis, C. ADHD and transitions to adult mental health services: A scoping review. Child: Care, Health and Development. 2014;40(6):775–86.CrossRefGoogle ScholarPubMed
Nutt, DJ, Fone, K, Asherson, P, et al. Evidence-based guidelines for management of attention-deficit/hyperactivity disorder in adolescents in transition to adult services and in adults: Recommendations from the British Association for Psychopharmacology. Journal of Psychopharmacology. 2007;21(1):10–41.CrossRefGoogle ScholarPubMed
Bolea-Alamanac, B, Nutt, DJ, Adamou, M, et al. Evidence-based guidelines for the pharmacological management of attention deficit hyperactivity disorder: Update on recommendations from the British Association for Psychopharmacology. Journal of Psychopharmacology. 2014;28(3):179–203.CrossRefGoogle ScholarPubMed
Young, S, Adamou, M, Asherson, P, et al. Recommendations for the transition of patients with ADHD from child to adult healthcare services: a consensus statement from the UK adult ADHD network. BMC Psychiatry. 2016;16:301.CrossRefGoogle ScholarPubMed
Biederman, J, Mick, E, Faraone, SV. Age-dependent decline of symptoms of attention deficit hyperactivity disorder: Impact of remission definition and symptom type. American Journal of Psychiatry. 2000;157(5):816–18.CrossRefGoogle ScholarPubMed
Demontis, D, Walters, RK, Martin, J, et al. Discovery of the first genome-wide significant risk loci for attention deficit/hyperactivity disorder. Nature Genetics. 2019;51(1):63–75.CrossRefGoogle ScholarPubMed
Rovira, P, Demontis, D, Sanchez-Mora, C, et al. Shared genetic background between children and adults with attention deficit/hyperactivity disorder. Neuropsychopharmacology. 2020;45(10):1617–26.CrossRefGoogle ScholarPubMed
Lee, SS, Humphreys, KL, Flory, K, Liu, R, Glass, K. Prospective association of childhood attention-deficit/hyperactivity disorder (ADHD) and substance use and abuse/dependence: A meta-analytic review. Clinical Psychology Review. 2011;31(3):328–41.CrossRefGoogle ScholarPubMed
van Amsterdam, J, van der Velde, B, Schulte, M, van den Brink, W. Causal factors of increased smoking in ADHD: A systematic review. Substance Use and Misuse. 2018;53(3):432–45.CrossRefGoogle ScholarPubMed
van Emmerik-van Oortmerssen, K, van de Glind, G, van den Brink, W, et al. Prevalence of attention-deficit hyperactivity disorder in substance use disorder patients: A meta-analysis and meta-regression analysis. Drug and Alcohol Dependence. 2012;122(1–2):11–19.CrossRefGoogle ScholarPubMed
Zulauf, CA, Sprich, SE, Safren, SA, Wilens, TE. The complicated relationship between attention deficit/hyperactivity disorder and substance use disorders. Current Psychiatry Reports. 2014;16(3):436.CrossRefGoogle ScholarPubMed
Charach, A, Yeung, E, Climans, T, Lillie, E. Childhood attention-deficit/hyperactivity disorder and future substance use disorders: comparative meta-analyses. Journal of the American Academy of Child & Adolescent Psychiatry. 2011;50(1):9–21.CrossRefGoogle ScholarPubMed
Hildebrand Karlen, M, Nilsson, T, Wallinius, M, Billstedt, E, Hofvander, B. A bad start: The combined effects of early onset substance use and ADHD and CD on criminality patterns, substance abuse and psychiatric comorbidity among young violent offenders. Journal for Person Oriented Research. 2020;6(1):39–54.CrossRefGoogle ScholarPubMed
Groenman, AP, Janssen, TWP, Oosterlaan, J. Childhood psychiatric disorders as risk factor for subsequent substance abuse: A meta-analysis. J Am Acad Child Adolesc Psychiatry. 2017;56(7):556–69.CrossRefGoogle ScholarPubMed
Erskine, HE, Norman, RE, Ferrari, AJ, et al. Long-term outcomes of attention-deficit/hyperactivity disorder and conduct disorder: A systematic review and meta-analysis. Journal of American Academic Child and Adolescent Psychiatry. 2016;55(10):841–50.Google ScholarPubMed
Vilar-Ribo, L, Sanchez-Mora, C, Rovira, P, et al. Genetic overlap and causality between substance use disorder and attention-deficit and hyperactivity disorder. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics. 2020;186(3):140–50.Google ScholarPubMed
Wilens, TE, Biederman, J, Mick, E. Does ADHD affect the course of substance abuse? Findings from a sample of adults with and without ADHD. American Journal of Addiction. 1998;7(2):156–63.Google ScholarPubMed
Iqbal, MN, Levin, CJ, Levin, FR. Treatment for substance use disorder with co-occurring mental illness. FOCUS. 2019;17(2):88–97.CrossRefGoogle ScholarPubMed
van der Burg, D, Crunelle, CL, Matthys, F, van den Brink, W. Diagnosis and treatment of patients with comorbid substance use disorder and adult attention-deficit and hyperactivity disorder: A review of recent publications. Current Opinion in Psychiatry. 2019;32(4):300–6.CrossRefGoogle ScholarPubMed
Crunelle, CL, van den Brink, W, Moggi, F, et al. International consensus statement on screening, diagnosis and treatment of substance use disorder patients with comorbid attention deficit/hyperactivity disorder. European Addiction Research. 2018;24(1):43–51.CrossRefGoogle ScholarPubMed
Perez de los Cobos, J, Sinol, N, Perez, V, Trujols, J. Pharmacological and clinical dilemmas of prescribing in co-morbid adult attention-deficit/hyperactivity disorder and addiction. British Journal of Clinical Pharmacology. 2014;77(2):337–56.CrossRefGoogle ScholarPubMed
Carpentier, PJ, Levin, FR. Pharmacological treatment of ADHD in addicted patients: What does the literature tell us? Harvard Review of Psychiatry. 2017;25(2):50–64.CrossRefGoogle ScholarPubMed
Konstenius, M, Jayaram-Lindstrom, N, Beck, O, Franck, J. Sustained release methylphenidate for the treatment of ADHD in amphetamine abusers: A pilot study. Drug and Alcohol Dependence. 2010;108(1–2):130–3.CrossRefGoogle ScholarPubMed
Levin, FR, Mariani, JJ, Specker, S, et al. Extended-release mixed amphetamine salts vs placebo for comorbid adult attention-deficit/hyperactivity disorder and cocaine use disorder: A randomized clinical trial. JAMA Psychiatry. 2015;72(6):593–602.CrossRefGoogle ScholarPubMed
Skoglund, C, Brandt, L, Almqvist, C, et al. Factors associated with adherence to methylphenidate treatment in adult patients with attention-deficit/hyperactivity disorder and substance use disorders. Journal of Clinical Psychopharmacology. 2016;36(3):222–8.CrossRefGoogle ScholarPubMed
Groenman, AP, Oosterlaan, J, Rommelse, N, et al. Substance use disorders in adolescents with attention deficit hyperactivity disorder: A 4-year follow-up study. Addiction. 2013;108(8):1503–11.CrossRefGoogle ScholarPubMed
Van Veen, MM, Kooij, JJ, Boonstra, AM, Gordijn, MC, Van Someren, EJ. Delayed circadian rhythm in adults with attention-deficit/hyperactivity disorder and chronic sleep-onset insomnia. Biological Psychiatry. 2010;67(11):1091–6.CrossRefGoogle ScholarPubMed
Van der Heijden, KB, Smits, MG, Van Someren, EJ, Gunning, WB. Idiopathic chronic sleep onset insomnia in attention-deficit/hyperactivity disorder: A circadian rhythm sleep disorder. Chronobiology International. 2005;22(3):559–70.CrossRefGoogle ScholarPubMed
Bijlenga, D, Van Someren, EJ, Gruber, R, et al. Body temperature, activity and melatonin profiles in adults with attention-deficit/hyperactivity disorder and delayed sleep: A case-control study. Journal of Sleep Research. 2013;22(6):607–16.CrossRefGoogle ScholarPubMed
Cortese, S, Konofal, E, Lecendreux, M, et al. Restless legs syndrome and attention-deficit/hyperactivity disorder: A review of the literature. Sleep. 2005;28(8):1007–13.CrossRefGoogle ScholarPubMed
Rogers, DC, Dittner, AJ, Rimes, KA, Chalder, T. Fatigue in an adult attention deficit hyperactivity disorder population: A trans-diagnostic approach. British Journal of Clinical Psychology/British Psychological Society. 2017;56(1):33–52.CrossRefGoogle Scholar
Schredl, M, Alm, B, Sobanski, E. Sleep quality in adult patients with attention deficit hyperactivity disorder (ADHD). European Archives of Psychiatry and Clinical Neuroscience. 2007;257(3):164–8.CrossRefGoogle ScholarPubMed
Snitselaar, MA, Smits, MG, Spijker, J. Prevalence of restless legs syndrome in adult ADHD and its subtypes. Behavioral Sleep Medicine. 2016;14(5):480–8.CrossRefGoogle ScholarPubMed
Vogel, SWN, Bijlenga, D, Benjamins, JS, et al. Attention deficit hyperactivity disorder symptom severity and sleep problems in adult participants of the Netherlands sleep registry. Sleep Medicine. 2017;40:94–102.CrossRefGoogle ScholarPubMed
Wynchank, D, Ten Have, M, Bijlenga, D, et al. The association between insomnia and sleep duration in adults with attention-deficit hyperactivity disorder: Results from a general population study. Journal of Clinical Sleep Medicine. 2018;14(3):349–57.CrossRefGoogle ScholarPubMed
Bijlenga, D, Vollebregt, MA, Kooij, JJS, Arns, M. The role of the circadian system in the etiology and pathophysiology of ADHD: Time to redefine ADHD? Attention Deficit and Hyperactivity Disorders. 2019;11(1):5–19.CrossRefGoogle ScholarPubMed
Helfer, B, Bozhilova, N, Cooper, RE, et al. The key role of daytime sleepiness in cognitive functioning of adults with attention deficit hyperactivity disorder. European Psychiatry. 2020;63(1):e31.CrossRefGoogle ScholarPubMed
Mason, TB, Engwall, A, Mead, MP, Irish, LA. Sleep and eating disorders among adults enrolled in a commercial weight loss program: Associations with self-report and objective sleep measures. Eating and Weight Disorders. 2019;24(2):307–12.CrossRefGoogle Scholar
Knutson, KL. Sleep duration and cardiometabolic risk: A review of the epidemiologic evidence. Best Practice & Research Clinical Endocrinology & Metabolism. 2010;24(5):731–43.CrossRefGoogle Scholar
Spiegel, K, Knutson, K, Leproult, R, Tasali, E, Van Cauter, E. Sleep loss: A novel risk factor for insulin resistance and Type 2 diabetes. Journal of Applied Physiology (1985). 2005;99(5):2008–19.CrossRefGoogle Scholar
Lutsey, PL, Misialek, JR, Mosley, TH, et al. Sleep characteristics and risk of dementia and Alzheimer’s disease: The Atherosclerosis Risk in Communities study. Alzheimers and Dementia. 2018;14(2):157–66.CrossRefGoogle ScholarPubMed
Corkum, P, Lingley-Pottie, P, Davidson, F, et al. Better nights/better days-distance intervention for insomnia in school-aged children with/without ADHD: A randomized controlled trial. Journal of Pediatric Psychology. 2016;41(6):701–13.CrossRefGoogle ScholarPubMed
Huang, YS, Guilleminault, C, Li, HY, et al. Attention-deficit/hyperactivity disorder with obstructive sleep apnea: A treatment outcome study. Sleep Medicine. 2007;8(1):18–30.CrossRefGoogle ScholarPubMed
Walters, AS, Mandelbaum, DE, Lewin, DS, et al. Dopaminergic therapy in children with restless legs/periodic limb movements in sleep and ADHD: Dopaminergic Therapy Study Group. Pediatric Neurology. 2000;22(3):182–6.CrossRefGoogle ScholarPubMed
Fargason, RE, Fobian, AD, Hablitz, LM, et al. Correcting delayed circadian phase with bright light therapy predicts improvement in ADHD symptoms: A pilot study. Journal of Psychiatric Research. 2017;91:105–10.CrossRefGoogle ScholarPubMed
Rybak, YE, McNeely, HE, Mackenzie, BE, Jain, UR, Levitan, RD. An open trial of light therapy in adult attention-deficit/hyperactivity disorder. Journal of Clinical Psychiatry. 2006;67(10):1527–35.Google ScholarPubMed
van Andel, E, Bijlenga, D, Vogel, SWN, Beekman, ATF, Kooij, JJS. Effects of chronotherapy on circadian rhythm and ADHD symptoms in adults with attention-deficit/hyperactivity disorder and delayed sleep phase syndrome: A randomized clinical trial. Chronobiology International. 2021;38(2):260–9.CrossRefGoogle ScholarPubMed
Pavlova, MK, Latreille, V, Puri, N, et al. Novel non-pharmacological insomnia treatment: A pilot study. Nature and Science of Sleep. 2019;11:189–95.CrossRefGoogle ScholarPubMed
Geschwind, N, Behan, P. Left-handedness: Association with immune disease, migraine, and developmental learning disorder. Proceedings of the National Academy of Sciences of the United States of America. 1982;79(16):5097–100.Google ScholarPubMed
Lehéron, C, Morin, AJS, Caci, H (Eds.) 985–ADHD and atopy are related: An exploratory study on 102 children. 21th European Congress of Psychiatry; 2013; Nice (France).Google Scholar
van der Schans, J, Çiçek, R, de Vries, TW, Hak, E, Hoekstra, PJ. Association of atopic diseases and attention-deficit/hyperactivity disorder: A systematic review and meta-analyses. Neuroscience and Biobehavioral Reviews. 2017;74(Pt A):139–48.Google Scholar
Miyazaki, C, Koyama, M, Ota, E, et al. Allergic diseases in children with attention deficit hyperactivity disorder: a systematic review and meta-analysis. BMC Psychiatry. 2017;17(120):1–12.CrossRefGoogle ScholarPubMed
Kendler, KS, Neale, MC. Endophenotype: A conceptual analysis. Molecular Psychiatry. 2010;15(8):789–97.CrossRefGoogle ScholarPubMed
Castellanos, FX, Tannock, R. Neuroscience of attention-deficit/hyperactivity disorder: The search for endophenotypes. Nature Reviews Neuroscience. 2002;3(8):617–28.CrossRefGoogle ScholarPubMed
Michelini, G, Cheung, CHM, Kitsune, V, et al. The etiological structure of cognitive-neurophysiological impairments in ADHD in adolescence and young adulthood. Journal of Attention Disorders. 2021;25(1):91–104.CrossRefGoogle ScholarPubMed
Bozhilova, NS, Michelini, G, Kuntsi, J, Asherson, P. Mind wandering perspective on attention-deficit/hyperactivity disorder. Neuroscience and Biobehavioral Reviews. 2018;92:464–76.CrossRefGoogle ScholarPubMed
Castellanos, FX, Proal, E. Large-scale brain systems in ADHD: Beyond the prefrontal-striatal model. Trends in Cognitive Sciences. 2012;16(1):17–26.CrossRefGoogle ScholarPubMed
Konrad, K, Dempfle, A, Friedel, S, et al. Familiality and molecular genetics of attention networks in ADHD. American Journal of Medical Genetics Part B, Neuropsychiatric Genetics: The Official Publication of the International Society of Psychiatric Genetics. 2010;153B(1):148–58.CrossRefGoogle ScholarPubMed
Plichta, MM, Scheres, A. Ventral–striatal responsiveness during reward anticipation in ADHD and its relation to trait impulsivity in the healthy population: A meta-analytic review of the fMRI literature. Neuroscience & Biobehavioral Reviews. 2014;38:125–34.CrossRefGoogle ScholarPubMed
Shaw, P, Eckstrand, K, Sharp, W, et al. Attention-deficit/hyperactivity disorder is characterized by a delay in cortical maturation. Proceedings of the National Academy of Sciences of the United States of America. 2007;104(49):19649–54.Google ScholarPubMed
Shaw, P, Sudre, G, Wharton, A, et al. White matter microstructure and the variable adult outcome of childhood attention deficit hyperactivity disorder. Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology. 2015;40(3):746–54.CrossRefGoogle ScholarPubMed
Shaw, P, Malek, M, Watson, B, et al. Trajectories of cerebral cortical development in childhood and adolescence and adult attention-deficit/hyperactivity disorder. Biological Psychiatry. 2013;74(8):599–606.CrossRefGoogle ScholarPubMed
Proal, E, Reiss, PT, Klein, RG, et al. Brain gray matter deficits at 33-year follow-up in adults with attention-deficit/hyperactivity disorder established in childhood. Archives of General Psychiatry. 2011;68(11):1122–34.CrossRefGoogle ScholarPubMed
Shaw, M, Hodgkins, P, Caci, H, et al. A systematic review and analysis of long-term outcomes in attention deficit hyperactivity disorder: Effects of treatment and non-treatment. BMC Medicine. 2012;10:99.CrossRefGoogle ScholarPubMed
Cortese, S, Imperati, D, Zhou, J, et al. White matter alterations at 33-year follow-up in adults with childhood attention-deficit/hyperactivity disorder. Biological Psychiatry. 2013;74(8):591–8.CrossRefGoogle ScholarPubMed
Cheung, CH, Rijsdijk, F, McLoughlin, G, et al. Cognitive and neurophysiological markers of ADHD persistence and remission. British Journal of Psychiatry. 2016;208(6):548–55.CrossRefGoogle ScholarPubMed
Szekely, E, Sudre, GP, Sharp, W, Leibenluft, E, Shaw, P. Defining the neural substrate of the adult outcome of childhood ADHD: A multimodal neuroimaging study of response inhibition. American Journal of Psychiatry. 2017;174(9):867–76.CrossRefGoogle ScholarPubMed
Sudre, G, Szekely, E, Sharp, W, Kasparek, S, Shaw, P. Multimodal mapping of the brain’s functional connectivity and the adult outcome of attention deficit hyperactivity disorder. Proceedings of the National Academy of Sciences of the United States of America. 2017;114(44):11787–92.Google ScholarPubMed
Bozhilova, N, Kuntsi, J, Rubia, K, Michelini, G, Asherson, P. Electrophysiological modulation of sensory and attentional processes during mind wandering in attention-deficit/hyperactivity disorder. Neuroimage: Clinical. 2021;29:102547.CrossRefGoogle ScholarPubMed
Bozhilova, N, Michelini, G, Jones, C, et al. Context regulation of mind wandering in ADHD. Journal of Attention Disorders. 2020:1087054720956714.CrossRefGoogle Scholar
Moukhtarian, TR, Reinhard, I, Morillas-Romero, A et al. Wandering minds in attention-deficit/hyperactivity disorder and borderline personality disorder. European Neuropsychopharmacology. 2020;38:98–109.CrossRefGoogle ScholarPubMed
Metin, B, Krebs, RM, Wiersema, JR, et al. Dysfunctional modulation of default mode network activity in attention-deficit/hyperactivity disorder. Journal of Abnormal Psychology. 2015;124(1):208–14.CrossRefGoogle ScholarPubMed

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