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18 - Surgical issues affecting patients with hemotologic malignancies

Published online by Cambridge University Press:  12 January 2010

By
Eve Rodler  and
Ted Wun
Edited by
Michael F. Lubin ,
Robert B. Smith ,
Thomas F. Dodson ,
Nathan O. Spell  and
H. Kenneth Walker
Eve Rodler
Affiliation:
Robert Wood Johnson School of Medicine, Camden, NJ
Ted Wun
Affiliation:
VA Northern California Health Care System, Sacramento, CA
Michael F. Lubin
Affiliation:
Emory University, Atlanta
Robert B. Smith
Affiliation:
Emory University, Atlanta
Thomas F. Dodson
Affiliation:
Emory University, Atlanta
Nathan O. Spell
Affiliation:
Emory University, Atlanta
H. Kenneth Walker
Affiliation:
Emory University, Atlanta
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Summary

Introduction

Hematologic malignancies are a heterogeneous group of malignant disorders that affect cells originating from bone marrow or lymphatic tissue. Patients with a diagnosis of leukemia, lymphoma, or multiple myeloma are susceptible to life-threatening crises such as leukostasis, disseminated intravascular coagulation, tumor lysis syndrome, infection, respiratory distress due to enlarging masses, and neutropenic enterocolitis (typhlitis). These serious problems may require surgical management or they may have an impact on the perioperative management of patients with hematologic malignancies. Surgery plays a role in the diagnosis of hematologic malignancies, including excisional lymph node biopsies, mediastinoscopy, or laparoscopy, in Hodgkin's and non-Hodgkin's lymphoma. Patients with hematologic malignancies may also present with common surgical problems, such as appendicitis, cholecystitis, bowel obstruction, ureteral obstruction, or bowel perforation due to infiltration of organs by malignant cells. There are also unique problems associated with the different types of hematologic malignancies which may require surgical intervention, such as: osteolytic bone lesions in multiple myeloma causing pathologic fractures; spinal cord compression due to multiple myeloma, lymphoma or solid tumors; hypersplenism in hairy cell leukemia; and neutropenic enterocolitis, perirectal abscesses, and locally invasive fungal infections during acute leukemia.

Indwelling venous access devices are often placed surgically for chronic central venous access to administer chemotherapy, long-term antibiotic therapy, blood and blood products, and total parenteral nutrition. Intraoperative complications related to the placement of central venous catheters are rare but include hemorrhage, pneumothorax, and hemothorax.

Type
Chapter
Information
Medical Management of the Surgical Patient
A Textbook of Perioperative Medicine
 , pp. 230 - 247
Publisher: Cambridge University Press
Print publication year: 2006

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References

Holleb, A. I., Fink, D. J., & Murphy, G. P.Textbook of Clinical Oncology, 1st edn. Atlanta: American Cancer Society, 1991.Google Scholar
Eastridge, B. J. & Lefor, A. T. Chronic venous access in the cancer patient. In Lefor, A. T., ed. Surgical Problems Affecting the Patient with Cancer: Interdisciplinary Management. Philadelphia: Lippincott-Raven, 1996.Google Scholar
Midis, G. P. & Skibber, J. Abdominal pain in the neutropenic cancer patient. In Lefor, A. T., ed. Surgical Problems Affecting the Patient with Cancer: Interdisciplinary Management. Philadelphia: Lippincott-Raven, 1996.Google Scholar
Mower, W. J., Hawkins, J. A., & Nelson, E. W.Neutropenic enterocolitis in adults with acute leukemia. Arch. Surg. 1986; 121(5): 571–574.CrossRefGoogle ScholarPubMed
Wade, D. S., Douglass, H. Jr., Nava, H. R., & Piedmonte, M.Abdominal pain in neutropenic patients. Arch. Surg. 1990; 125(9): 1119–1127.CrossRefGoogle ScholarPubMed
Villar, H. V., Warneke, J. A., Peck, M. D.et al. Role of surgical treatment in the management of complications of the gastrointestinal tract in patients with leukemia. Surg. Gynecol. Obstet. 1987; 165(3): 217–222.Google ScholarPubMed
Starnes, H. F.., Moore, F. D.., Mentzer, S.et al. Abdominal pain in neutropenic cancer patients. Cancer 1986; 57(3): 616–621.3.0.CO;2-4>CrossRefGoogle ScholarPubMed
Glenn, J., Funkhouser, W. K., & Schneider, P. S.Acute illnesses necessitating urgent abdominal surgery in neutropenic cancer patients: description of 14 cases and review of the literature. Surgery 1989; 105(6): 778–789.Google ScholarPubMed
Martell, R. W. & Jacobs, P.Surgery for the acute abdomen in adults with leukaemia. Postgrad. Med. J. 1986; 62(732): 915–918.CrossRefGoogle ScholarPubMed
Weinberger, M., Hollingsworth, H., Feuerstein, I. M.et al. Successful surgical management of neutropenic enterocolitis in two patients with severe aplastic anemia. Case reports and review of the literature. Arch. Intern. Med. 1993; 153(1): 107–113.CrossRefGoogle ScholarPubMed
Baerg, J., Murphy, J. J., Anderson, R., & Magee, J. F.Neutropenic enteropathy: a 10-year review. J. Pediatr. Surg. 1999; 34(7): 1068–1071.CrossRefGoogle ScholarPubMed
Keidan, R. D., Fanning, J., Gatenby, R. A., & Weese, J. L.Recurrent typhlitis. A disease resulting from aggressive chemotherapy. Dis. Colon Rectum 1989; 32(3): 206–209.CrossRefGoogle ScholarPubMed
Newbold, K. M.Neutropenic enterocolitis. Clinical and pathological review. Dig. Dis. 1989; 7(6): 281–287.CrossRefGoogle ScholarPubMed
Dosik, G. M., Luna, M., Valdivieso, M.et al. Necrotizing colitis in patients with cancer. Am. J. Med. 1979; 67(4): 646–656.CrossRefGoogle ScholarPubMed
Coleman, N., Speirs, G., Khan, J.et al. Neutropenic enterocolitis associated with Clostridium tertium. J. Clin. Pathol. 1993; 46(2): 180–183.CrossRefGoogle ScholarPubMed
Ettinghausen, S. E.Collagenous colitis, eosinophilic colitis, and neutropenic colitis. Surg. Clin. North Am. 1993; 73(5): 993–1016.CrossRefGoogle ScholarPubMed
Newbold, K. M., Lord, M. G., & Baglin, T. P.Role of clostridial organisms in neutropenic enterocolitis. J. Clin. Pathol. 1987; 40(4): 471.CrossRefGoogle ScholarPubMed
Moir, C. R., Scudamore, C. H., & Benny, W. B.Typhlitis: selective surgical management. Am. J. Surg. 1986; 151(5): 563–566.CrossRefGoogle ScholarPubMed
Alt, B., Glass, N. R., & Sollinger, H.Neutropenic enterocolitis in adults. Review of the literature and assessment of surgical intervention. Am. J. Surg. 1985; 149(3): 405–408.CrossRefGoogle ScholarPubMed
Adams, G. W., Rauch, R. F., Kelvin, F. M.et al. CT detection of typhlitis. J. Comput. Assist. Tomogr. 1985; 9(2): 363–365.CrossRefGoogle ScholarPubMed
Frick, M. P., Maile, C. W., Crass, J. R.et al. Computed tomography of neutropenic colitis. Am. J. Roentgenol. 1984; 143(4): 763–765.CrossRefGoogle ScholarPubMed
Wade, D. S., Nava, H. R., & Douglass, H. O. Jr.Neutropenic enterocolitis. Clinical diagnosis and treatment. Cancer 1992; 69(1): 17–23.3.0.CO;2-X>CrossRefGoogle ScholarPubMed
Eiff, M., Essink, M., Roos, N.et al. Hepatosplenic candidiasis, a late manifestation of Candida septicaemia in neutropenic patients with haematologic malignancies. Blut 1990; 60(4): 242–248.CrossRefGoogle Scholar
Blade, J., Lopez-Guillermo, A., Rozman, C.et al. Chronic systemic candidiasis in acute leukemia. Ann. Hematol. 1992; 64(5): 240–244.CrossRefGoogle ScholarPubMed
Morris, A. B., Sands, M. L., Shiraki, M.et al. Gallbladder and biliary tract candidiasis: nine cases and review. Rev. Infect. Dis. 1990; 12(3): 483–489.CrossRefGoogle ScholarPubMed
Page, C. P., Coltman, C. A., Robertson, H. D., & Nelson, E. A.Candidal abscess of the spleen in patients with acute leukemia. Surg. Gynecol. Obstet. 1980; 151(5): 604–608.Google ScholarPubMed
Significance and implications of abdominal pain in autologous bone marrow transplant patients. 89 May 21; 1989.
Vogelsang, G. B.Acute and chronic graft-versus-host disease. Curr. Opin. Oncol. 1993; 5(2): 276–281.CrossRefGoogle ScholarPubMed
McDonald, G. B., Shulman, H. M., Sullivan, K. M., & Spencer, G. D.Intestinal and hepatic complications of human bone marrow transplantation. Part I. Gastroenterology 1986; 90(2): 460–477.CrossRefGoogle ScholarPubMed
Goker, H., Haznedaroglu, I. C., & Chao, N. J.Acute graft-vs-host disease: pathobiology and management. Exp. Hematol. 2001; 29(3): 259–277.CrossRefGoogle ScholarPubMed
Barnes, S. G., Sattler, F. R., & Ballard, J. O.Perirectal infections in acute leukemia. Improved survival after incision and debridement. Ann. Intern. Med. 1984; 100(4): 515–518.CrossRefGoogle ScholarPubMed
Birnbaum, W. & Ahlquist, R.Rectal infections and ulcerations associated with blood dyscrasias. Am. J. Surg. 1955; 90(2): 367–372.CrossRefGoogle ScholarPubMed
Blank, W. A.Anorectal complications in leukemia. Am. J. Surg. 1955; 90(5): 738–741.CrossRefGoogle ScholarPubMed
Quadri, T. L. & Brown, A. E.Infectious complications in the critically ill patient with cancer. Semin. Oncol. 2000; 27(3): 335–346.Google ScholarPubMed
Glenn, J., Cotton, D., Wesley, R., & Pizzo, P.Anorectal infections in patients with malignant diseases. Rev. Infect. Dis. 1988; 10(1): 42–52.CrossRefGoogle ScholarPubMed
Troiani, R. T. Jr., DuBois, J. J., & Boyle, L.Surgical management of anorectal infection in the leukemic patient. Milit. Med. 1991; 156(10): 558–561.CrossRefGoogle ScholarPubMed
Boddie, A. W. Jr. & Bines, S. D.Management of acute rectal problems in leukemic patients. J. Surg. Oncol. 1986; 33(1): 53–56.CrossRefGoogle ScholarPubMed
Bodey, G., Bueltmann, B., Duguid, W.et al. Fungal infections in cancer patients: an international autopsy survey. Eur. J. Clin. Microbiol. Infect. Dis. 1992; 11(2): 99–109.CrossRefGoogle ScholarPubMed
Baron, O., Guillaume, B., Moreau, P.et al. Aggressive surgical management in localized pulmonary mycotic and nonmycotic infections for neutropenic patients with acute leukemia: report of eighteen cases. J. Thorac. Cardiovasc. Surg. 1998; 115(1): 63–68.CrossRefGoogle ScholarPubMed
Moreau, P., Zahar, J. R., Milpied, N.et al. Localized invasive pulmonary aspergillosis in patients with neutropenia. Effectiveness of surgical resection. Cancer 1993; 72(11): 3223–3226.3.0.CO;2-R>CrossRefGoogle ScholarPubMed
Robinson, L. A., Reed, E. C., Galbraith, T. A.et al. Pulmonary resection for invasive Aspergillus infections in immunocompromised patients. J. Thorac. Cardiovasc. Surg. 1995; 109(6): 1182–1196.CrossRefGoogle ScholarPubMed
Wong, K., Waters, C. M., & Walesby, R. K.Surgical management of invasive pulmonary aspergillosis in immunocompromised patients. Eur. J. Cardiothorac. Surg. 1992; 6(3): 138–142.CrossRefGoogle ScholarPubMed
Young, V. K., Maghur, H. A., Luke, D. A., & McGovern, E. M.Operation for cavitating invasive pulmonary aspergillosis in immunocompromised patients. Ann. Thorac. Surg. 1992; 53(4): 621–624.CrossRefGoogle ScholarPubMed
Sutton, D. A., Sanche, S. E., Revankar, S. G.et al. In vitro amphotericin B resistance in clinical isolates of Aspergillus terreus, with a head-to-head comparison to voriconazole. J. Clin. Microbiol. 1999; 37(7): 2343–2345.Google Scholar
Caillot, D., Casasnovas, O., Bernard, A.et al. Improved management of invasive pulmonary aspergillosis in neutropenic patients using early thoracic computed tomographic scan and surgery. J. Clin. Oncol. 1997; 15(1): 139–147.CrossRefGoogle ScholarPubMed
Offner, F., Cordonnier, C., Ljungman, P.et al. Impact of previous aspergillosis on the outcome of bone marrow transplantation. Clin. Infect. Dis. 1998; 26(5): 1098–1103.CrossRefGoogle ScholarPubMed
Segal, B. H., Walsh, T. J., & Holland, S. M. Infections in the cancer patient. In Devita, V. T. Jr. HSRS, ed. Cancer Principles and Practice of Oncology. Philadelphia: Lippincott-Raven, 2001: 2827–2828.Google Scholar
Hughes, W. T., Armstrong, D., Bodey, G. P.et al. 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin. Infect. Dis. 2002; 34(6): 730–751.CrossRefGoogle ScholarPubMed
Akova, M., Akan, H., Korten, V.et al. Meropenem Study Group of Turkey. Comparison of meropenem with amikacin plus ceftazidime in the empirical treatment of febrile neutropenia: a prospective randomised multicentre trial in patients without previous prophylactic antibiotics. Int. J. Antimicrob. Agents 1999; 13(1): 15–19.CrossRefGoogle Scholar
Cometta, A., Calandra, T., Gaya, H.et al. The International Antimicrobial Therapy Cooperative Group of the European Organization for Research and Treatment of Cancer and the Gruppo Italiano Malattie Ematologiche Maligne dell'Adulto Infection Program. Monotherapy with meropenem versus combination therapy with ceftazidime plus amikacin as empiric therapy for fever in granulocytopenic patients with cancer. Antimicrob. Agents Chemother. 1996; 40(5): 1108–1115.Google Scholar
Pauw, B. E., Deresinski, S. C., Feld, R.et al. The Intercontinental Antimicrobial Study Group. Ceftazidime compared with piperacillin and tobramycin for the empiric treatment of fever in neutropenic patients with cancer. A multicenter randomized trial. Ann. Intern. Med. 1994; 120(10): 834–844.CrossRefGoogle Scholar
Feld, R., DePauw, B., Berman, S.et al. Meropenem versus ceftazidime in the treatment of cancer patients with febrile neutropenia: a randomized, double-blind trial. J. Clin. Oncol. 2000; 18(21): 3690–3698.CrossRefGoogle ScholarPubMed
Pizzo, P. A., Hathorn, J. W., Hiemenz, J.et al. A randomized trial comparing ceftazidime alone with combination antibiotic therapy in cancer patients with fever and neutropenia. N. Engl. J. Med. 1986; 315(9): 552–558.CrossRefGoogle ScholarPubMed
Ramphal, R.Is monotherapy for febrile neutropenia still a viable alternative? Clin. Infect. Dis. 1999; 29(3): 508–514.CrossRefGoogle Scholar
Wang, F. D., Liu, C. Y., Hsu, H. C.et al. A comparative study of cefepime versus ceftazidime as empiric therapy of febrile episodes in neutropenic patients. Chemotherapy 1999; 45(5): 370–379.CrossRefGoogle ScholarPubMed
Malik, I. A., Abbas, Z., & Karim, M.Randomised comparison of oral ofloxacin alone with combination of parenteral antibiotics in neutropenic febrile patients. Lancet 1992; 339(8801): 1092–1096.CrossRefGoogle ScholarPubMed
Del Favero, A., Menichetti, F., Martino, P.et al. A multicenter, double-blind, placebo-controlled trial comparing piperacillin-tazobactam with and without amikacin as empiric therapy for febrile neutropenia. Clin. Infect. Dis. 2001; 33(8): 1295–1301.CrossRefGoogle ScholarPubMed
Yamamura, D., Gucalp, R., Carlisle, P.et al. Open randomized study of cefepime versus piperacillin-gentamicin for treatment of febrile neutropenic cancer patients. Antimicrob. Agents Chemother. 1997; 41(8): 1704–1708.Google ScholarPubMed
A randomized trial of cefepime vs. cefaidime as initial therapy for patients with prolonged fever and neutropenia after intensive chemotherapy [abstract].: 1993.
Schiffer, C. A., Anderson, K. C., Bennett, C. L.et al. Platelet transfusion for patients with cancer: clinical practice guidelines of the American Society of Clinical Oncology. J. Clin. Oncol. 2001; 19(5): 1519–1538.CrossRefGoogle ScholarPubMed
Rebulla, P.Platelet transfusion trigger in difficult patients. Transfus. Clin. Biol. 2001; 8(3): 249–254.CrossRefGoogle ScholarPubMed
Williamson, L. M. & Warwick, R. M.Transfusion-associated graft-versus-host disease and its prevention. Blood Rev. 1995; 9(4): 251–261.CrossRefGoogle ScholarPubMed
Ratko, T. A., Cummings, J. P., Oberman, H. A.et al. Evidence-based recommendations for the use of WBC-reduced cellular blood components. Transfusion 2001; 41(10): 1310–1319.CrossRefGoogle ScholarPubMed
Slichter, S. J.Platelet refractoriness and alloimmunization. Leukemia. 1998; 12 Suppl 1: S51–S53.Google ScholarPubMed
British Committee for Standards in Haematology, Blood Transfusion Task Force. Guidelines on the clinical use of leucocyte-depleted blood components. Transfus. Med. 1998; 8(1): 59–71.CrossRef
Kwaan, H. C., Wang, J., & Boggio, L. N.Abnormalities in hemostasis in acute promyelocytic leukemia. Hematol. Oncol. 2002; 20(1): 33–41.CrossRefGoogle ScholarPubMed
Rodeghiero, F., Avvisati, G., Castaman, G.et al. Early deaths and anti-hemorrhagic treatments in acute promyelocytic leukemia. A GIMEMA retrospective study in 268 consecutive patients. Blood 1990; 75(11): 2112–2117.Google ScholarPubMed
Fleming, D. R. & Doukas, M. A.Acute tumor lysis syndrome in hematologic malignancies. Leuk. Lymphoma. 1992; 8(4–5): 315–318.CrossRefGoogle ScholarPubMed
Jeha, S.Tumor lysis syndrome. Semin. Hematol. 2001; 38(4 Suppl 10): 4–8.CrossRefGoogle ScholarPubMed
Flombaum, C. D.Metabolic emergencies in the cancer patient. Semin. Oncol. 2000; 27(3): 322–334.Google ScholarPubMed
Giles, F. J., Shen, Y., Kantarjian, H. M.et al. Leukapheresis reduces early mortality in patients with acute myeloid leukemia with high white cell counts but does not improve long-term survival. Leuk. Lymphoma 2001; 42(1–2): 67–73.CrossRefGoogle Scholar
Leonard, A. S., Giebink, G. S., Baesl, T. J., & Krivit, W.The overwhelming postsplenectomy sepsis problem. World J. Surg. 1980; 4(4): 423–432.CrossRefGoogle ScholarPubMed
Seymour, J. F., Cusack, J. D., Lerner, S. A.et al. Case/control study of the role of splenectomy in chronic lymphocytic leukemia. J. Clin. Oncol. 1997; 15(1): 52–60.CrossRefGoogle ScholarPubMed
Kalhs, P., Schwarzinger, I., Anderson, G.et al. A retrospective analysis of the long-term effect of splenectomy on late infections, graft-versus-host disease, relapse, and survival after allogeneic marrow transplantation for chronic myelogenous leukemia. Blood 1995; 86(5): 2028–2032.Google ScholarPubMed
Morrison, V. A.The infectious complications of chronic lymphocytic leukemia. Semin. Oncol. 1998; 25(1): 98–106.Google ScholarPubMed
Anaissie, E. J., Kontoyiannis, D. P., O'Brien, S.et al. Infections in patients with chronic lymphocytic leukemia treated with fludarabine. Ann. Intern. Med. 1998; 129(7): 559–566.CrossRefGoogle ScholarPubMed
Maung, Z. T., Wood, A. C., Jackson, G. H.et al. Transfusion-associated graft-versus-host disease in fludarabine-treated B-chronic lymphocytic leukaemia. Br. J. Haematol. 1994; 88(3): 649–652.CrossRefGoogle ScholarPubMed
Lee, G. R., Foerster, J., Lukens, J., Paraskevas, F., Greer, J. P., & Rodgers, G. M. eds. Hairy Cell Leukemia. Baltimore: Lippincott, Williams & Wilkins, 1999.Google Scholar
Golde, D. W.Therapy of hairy-cell leukemia. N. Engl. J. Med. 1982; 307(8): 495–496.CrossRefGoogle ScholarPubMed
Magee, M. J., McKenzie, S., Filippa, D. A.et al. Hairy cell leukemia. Durability of response to splenectomy in 26 patients and treatment of relapse with androgens in six patients. Cancer 1985; 56(11): 2557–2562.3.0.CO;2-T>CrossRefGoogle ScholarPubMed
Andrey, J. & Saven, A.Therapeutic advances in the treatment of hairy cell leukemia. Leuk. Res. 2001; 25(5): 361–368.CrossRefGoogle ScholarPubMed
Savoie, L. & Johnston, J. B.Hairy cell leukemia. Curr. Treatm. Options Oncol. 2001; 2(3): 217–224.CrossRefGoogle ScholarPubMed
Hasenclever, D. & Diehl, V.A prognostic score for advanced Hodgkin's disease. International Prognostic Factors Project on Advanced Hodgkin's Disease. N. Engl. J. Med. 1998; 339(21): 1506–1514.CrossRefGoogle ScholarPubMed
Horning, S. J., Rosenberg, S. A., & Hoppe, R. T.Brief chemotherapy (Stanford V) and adjuvant radiotherapy for bulky or advanced Hodgkin's disease: an update. Ann. Oncol. 1996; 7(Suppl. 4): 105–108.CrossRefGoogle ScholarPubMed
Gossot, D., Girard, P., Kerviler, E.et al. Thoracoscopy or CT-guided biopsy for residual intrathoracic masses after treatment of lymphoma. Chest 2001; 120(1): 289–294.CrossRefGoogle ScholarPubMed
Ionescu, I., Brice, P., Simon, D.et al. Restaging with gallium scan identifies chemosensitive patients and predicts survival of poor-prognosis mediastinal Hodgkin's disease patients. Med. Oncol. 2000; 17(2): 127–134.CrossRefGoogle ScholarPubMed
Stumpe, K. D., Urbinelli, M., Steinert, H. C.et al. Whole-body positron emission tomography using fluorodeoxyglucose for staging of lymphoma: effectiveness and comparison with computed tomography. Eur. J. Nucl. Med. 1998; 25(7): 721–728.CrossRefGoogle ScholarPubMed
Jerusalem, G., Beguin, Y., Fassotte, M. F.et al. Whole-body positron emission tomography using 18F-fluorodeoxyglucose for posttreatment evaluation in Hodgkin's disease and non-Hodgkin's lymphoma has higher diagnostic and prognostic value than classical computed tomography scan imaging. Blood 1999; 94(2): 429–433.Google Scholar
Weingrad, D. N., DeCosse, J. J., Sherlock, P.et al. Primary gastrointestinal lymphoma: a 30-year review. Cancer 1982; 49(6): 1258–1265.3.0.CO;2-4>CrossRefGoogle ScholarPubMed
Torosian, M. H. & Turnbull, A. D.Emergency laparotomy for spontaneous intestinal and colonic perforations in cancer patients receiving corticosteroids and chemotherapy. J. Clin. Oncol. 1988; 6(2): 291–296.CrossRefGoogle ScholarPubMed
Horning, S. Hodgkin lymphoma. In Beutler, E., Lichtman, M. A., Coller, B. S., Kipps, T. J., & Seligsohn, U. eds. Williams Hematology. 6th edn. New York: McGraw Hill, 2001: 1215–1236.Google Scholar
Dinsmore, R. E., Straus, D. J., Pollack, M. S.et al. Fatal graft-versus-host disease following blood transfusion in Hodgkin's disease documented by HLA typing. Blood 1980; 55(5): 831–834.Google ScholarPubMed
, F. V., Higby, D. J., & Kim, U.Graft-versus-host reaction following blood product transfusion. Am. J. Med. 1982; 72(6): 951–961.Google Scholar
Decoste, S. D., Boudreaux, C., & Dover, J. S.Transfusion-associated graft-vs-host disease in patients with malignancies. Report of two cases and review of the literature. Arch. Dermatol. 1990; 126(10): 1324–1329.CrossRefGoogle ScholarPubMed
Gelly, K. J., Kerr, R., Rawlinson, S.et al. Transfusion-associated graft vs. host disease in a patient with high-grade B-cell lymphoma. Should cellular products for patients with non-Hodgkin's lymphoma be irradiated? Br. J. Haematol. 2000; 110(1): 228–229.CrossRefGoogle Scholar
Spitzer, T. R., Cahill, R., Cottler-Fox, M.et al. Transfusion-induced graft-versus-host disease in patients with malignant lymphoma. A case report and review of the literature. Cancer 1990; 66(11): 2346–2349.3.0.CO;2-T>CrossRefGoogle ScholarPubMed
Yahalom, J. Oncologic Emergencies. In Devita, V. T. Jr., Hellman, S., & Rosenberg, S. A. eds. Cancer Principles and Practice of Oncology. Philadelphia: Lippincott, Williams and Wilkins, 2001: 2609–2616.Google Scholar
Schindler, N. & Vogelzang, R. L.Superior vena cava syndrome. Experience with endovascular stents and surgical therapy. Surg. Clin. North Am. 1999; 79(3): 683–694, xi.CrossRefGoogle ScholarPubMed
Jahangiri, M. & Goldstraw, P.The role of mediastinoscopy in superior vena caval obstruction. Ann. Thorac. Surg. 1995; 59(2): 453–455.CrossRefGoogle ScholarPubMed
Mineo, T. C., Ambrogi, V., Nofroni, I., & Pistolese, C.Mediastinoscopy in superior vena cava obstruction: analysis of 80 consecutive patients. Ann. Thorac. Surg. 1999; 68(1): 223–226.CrossRefGoogle ScholarPubMed
Cozzolino, F., Torcia, M., Aldinucci, D.et al. Production of interleukin-1 by bone marrow myeloma cells. Blood 1989; 74(1): 380–387.Google ScholarPubMed
Garrett, I. R., Durie, B. G., Nedwin, G. E.et al. Production of lymphotoxin, a bone-resorbing cytokine, by cultured human myeloma cells. N. Engl. J. Med. 1987; 317(9): 526–532.CrossRefGoogle ScholarPubMed
Mundy, G. R., Raisz, L. G., Cooper, R. A.et al. Evidence for the secretion of an osteoclast stimulating factor in myeloma. N. Engl. J. Med. 1974; 291(20): 1041–1046.CrossRefGoogle Scholar
Barlogie, B., Shaughnessy, J., Munshi, N., & Epstein, J. Plasma cell myeloma. In Beutler, E., Lichtman, M. A., Coller, B. S., Kipps, T. J., & Seligsohn, U. eds. Williams Hematology. 6th edn. New York: McGraw Hill, 2001: 1279–1304.Google Scholar
McLain, R. F. & Bell, G. R.Newer management options in patients with spinal metastasis. Cleve. Clin. J. Med. 1998; 65(7): 359–366.Google ScholarPubMed
Glaspy, J. A.Hemostatic abnormalities in multiple myeloma and related disorders. Hematol. Oncol. Clin. North Am. 1992; 6(6): 1301–1314.CrossRefGoogle ScholarPubMed
Zangari, M., Anaissie, E., Barlogie, B.et al. Increased risk of deep-vein thrombosis in patients with multiple myeloma receiving thalidomide and chemotherapy. Blood 2001; 98(5): 1614–1615.CrossRefGoogle ScholarPubMed
Zangari, M., Saghafifar, F., Anaissie, E.et al. Activated protein C resistance in the absence of factor V Leiden mutation is a common finding in multiple myeloma and is associated with an increased risk of thrombotic complications. Blood Coagul. Fibrinol. 2002; 13(3): 187–192.CrossRefGoogle ScholarPubMed
Bloch, K. J. & Maki, D. G.Hyperviscosity syndromes associated with immunoglobulin abnormalities. Semin. Hematol. 1973; 10(2): 113–124.Google ScholarPubMed
Kwaan, H. C. & Bongu, A.The hyperviscosity syndromes. Semin. Thromb. Hemost. 1999; 25(2): 199–208.CrossRefGoogle ScholarPubMed
Solomon, A., Weiss, D. T., & Kattine, A. A.Nephrotoxic potential of Bence Jones proteins. N. Engl. J. Med. 1991; 324(26): 1845–1851.CrossRefGoogle ScholarPubMed
Gertz, M. A., Fonseca, R., & Rajkumar, S. V.Waldenstrom's macroglobulinemia. Oncologist 2000; 5(1): 63–67.CrossRefGoogle ScholarPubMed
Raad, I. I. & Hanna, H. A.Intravascular catheter-related infections: new horizons and recent advances. Arch. Intern. Med. 2002; 162(8): 871–878.CrossRefGoogle ScholarPubMed
Byers, K., Adal, K., Anglim, A., & Farr, B.Case fatality rate for catheter-related blood stream infections (CRBSI): a meta-analysis. Infect. Contr. Hosp. Epidemiol. 1995;16–23.Google Scholar
Pearson, M. L.Guideline for prevention of intravascular device-related infections. Part I. Intravascular device-related infections: an overview. The Hospital Infection Control Practices Advisory Committee. Am. J. Infect. Contr. 1996; 24(4): 262–277.Google ScholarPubMed
Lane, R. K. & Matthay, M. A.Central line infections. Curr. Opin. Crit. Care. 2002; 8(5): 441–448.CrossRefGoogle ScholarPubMed
Nucci, M. & Anaissie, E.Should vascular catheters be removed from all patients with candidemia? An evidence-based review. Clin. Infect. Dis. 2002; 34(5): 591–599.CrossRefGoogle ScholarPubMed
Wagman, L. D., Kirkemo, A., & Johnston, M. R.Venous access: a prospective, randomized study of the Hickman catheter. Surgery 1984; 95(3): 303–308.Google ScholarPubMed

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