Holmes also presented his thoughts about phrenology and its purveyors in what he called his three “medicated novels,” which also began as serials in the Atlantic Monthly before coming out as books. The first was Elsie Venner, published as a book in 1861. The Guardian Angel followed in 1867 and A Mortal Antipathy in 1885. In these three works, he asks pertinent questions, such as whether people with mental disabilities are morally responsible and are accountable for their crimes. He is bothered by how the insane rarely received proper attention from physicians or compassion and understanding from the public. Another common theme is how mental traits can be transmitted through multiple generations. These were the same issues that the founders of phrenology raised, and he is in agreement with them. Yet he also states that phrenology “has failed to demonstrate its system of special correspondences.” That is, its system of bumps is worthless or, as put by the brilliant Lurida Vincent, “nonsense.” This chapter concludes with what a leading phrenologist wrote about Holmes after he died in 1894. He felt Holmes was a gifted writer, yet, and as might be expected, one very much mistaken about phrenology being a pseudoscience.