Book contents
- Marijuana and Madness
- Marijuana and Madness
- Copyright page
- Contents
- Contributors
- Preface
- Part I Pharmacology of Cannabis and the Endocannabinoid System
- Part II The Changing Face of Cannabis
- Part III Cannabis and the Brain
- Part IV Cannabis, Anxiety, and Mood
- Part V Cannabis and Psychosis
- Chapter 14 Cannabis and Psychosis Proneness
- Chapter 15 Which Cannabis Users Develop Psychosis?
- Chapter 16 Cannabis Causes Positive, Negative, and Cognitive Symptoms and Produces Impairments in Electrophysiological Indices of Information Processing
- Part VI Cannabinoids and Schizophrenia: Aetiopathology and Treatment Implications
- Part VII Cannabinoids and Schizophrenia: Aetiopathology and Treatment Implications
- Part VIII Special Topics
- Index
- References
Chapter 14 - Cannabis and Psychosis Proneness
from Part V - Cannabis and Psychosis
Published online by Cambridge University Press: 12 May 2023
- Marijuana and Madness
- Marijuana and Madness
- Copyright page
- Contents
- Contributors
- Preface
- Part I Pharmacology of Cannabis and the Endocannabinoid System
- Part II The Changing Face of Cannabis
- Part III Cannabis and the Brain
- Part IV Cannabis, Anxiety, and Mood
- Part V Cannabis and Psychosis
- Chapter 14 Cannabis and Psychosis Proneness
- Chapter 15 Which Cannabis Users Develop Psychosis?
- Chapter 16 Cannabis Causes Positive, Negative, and Cognitive Symptoms and Produces Impairments in Electrophysiological Indices of Information Processing
- Part VI Cannabinoids and Schizophrenia: Aetiopathology and Treatment Implications
- Part VII Cannabinoids and Schizophrenia: Aetiopathology and Treatment Implications
- Part VIII Special Topics
- Index
- References
Summary
Cannabis use is associated with the development of psychosis in multiple studies. With increasing cannabis use worldwide, it is important to identify individuals who are at risk of developing psychosis following cannabis use. The concept of psychosis proneness has evolved over the past century from schizotypy, to denote people at clinical high risk for psychosis (CHR), those at genetic risk of schizophrenia (defined by polygenic risk score for schizophrenia), and those who experience attenuated psychotic symptoms in the general population. Across these definitions of psychosis proneness, cannabis use has been shown to increase the risk of psychosis expression. General population samples show that cannabis interacts with other environmental risk factors, such as childhood trauma and urbanicity, as well as with genetic liability in an additive manner, such that the risk of psychosis expression is greater with increasing number of risk factors. The role of affective dysregulation in increasing the risk of psychosis expression is also recognized. While biological and psychological studies suggest the role of striatal dopamine release, reasoning bias, impairment in face processing, and working memory, the precise biological underpinnings of the effects of cannabis use on psychosis proneness remain to be elucidated.
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- Marijuana and Madness , pp. 139 - 147Publisher: Cambridge University PressPrint publication year: 2023