A robust quality management system (QMS) is crucial to ensure the oocyte collection procedure in the IVF laboratory is fit for purpose. The QMS is a stipulation of the HFEA licence and comprises quality control, quality assurance and quality improvement. For a successful egg collection, the following quality aspects must be considered: equipment selection and validation, temperature monitoring, air quality, reprotoxicity, traceability, batch testing, risk assessment, training, process validation, competence, key performance indicators, audit, documentation, and third-party agreements. Quality activities are infiltrated throughout the whole process of egg collection to achieve the best possible outcome for the patient, and to make continual improvements.