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Chapter 5 - The Oocyte’s Role in Embryo Development

Published online by Cambridge University Press:  26 April 2023

By
David F. Albertini
Edited by
Catherine Racowsky ,
Jacques Cohen  and
Nicholas Macklon
Catherine Racowsky
Affiliation:
Hôpital Foch, France
Jacques Cohen
Affiliation:
IVF 2.0, New York
Nicholas Macklon
Affiliation:
London Women's Clinic
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Summary

For embryo development to proceed, the female gamete or oocyte must acquire and express nuclear and cytoplasmic determinants prior to, during, and following fertilization. The biological principles acquired during the process of oogenesis, involving hypertrophy, reorganization, and storage of maternal factors, must be coupled temporally with a phase of “maturation” occurring at the time of ovulation. In human ARTs, controlled ovarian stimulation (COS) is used to sustain the final stages of oogenesis with “maturation” being elicited by pharmacologically triggering ovulation. This chapter focuses on the maturation process in mammalian oocytes from a biological and clinical point of view emphasizing the role of maternal determinants in initiating and sustaining development of the embryo.

Type
Chapter
Information
Manual of Embryo Selection in Human Assisted Reproduction , pp. 43 - 52
Publisher: Cambridge University Press
Print publication year: 2023

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References

Coticchio, G, Albertini, DF, De Santis, L, editors. Oogenesis. New York: Springer; 2013.Google Scholar
Albertini, DF. The mammalian oocyte. In: Plant, T, Zeleznik, A, editors. Knobil and Neill’s Physiology of Reproduction. 4th ed. New York: Elsevier; 2015. p. 59–97.CrossRefGoogle Scholar
Vassena, R, members of the EBART group. Evidence-based medicine in ART. Hum Reprod. 2017;32(1):256.Google ScholarPubMed
De los Santos, MJ, Apter, S, Coticchio, G, Debrock, S, Lundin, K, et al. Revised guidelines for good practice in IVF laboratories (2015). Hum Reprod. 2016;31(4):685–6.Google Scholar
Krisher, RL. The effect of oocyte quality on development. J Anim Sci. 2004;82(E-Suppl.):E14–23.Google ScholarPubMed
Weghofer, A, Kushnir, VA, Darmon, SK, Jafri, H, Lazzaroni-Tealdi, E, Zhang, L, et al. Age, body weight and ovarian function affect oocyte size and morphology in non-PCOS patients undergoing intracytoplasmic sperm injection (ICSI). PLoS ONE. 2019;14(10):e0222390.CrossRefGoogle ScholarPubMed
Conti, M, Franciosi, F. Acquisition of oocyte competence to develop as an embryo: integrated nuclear and cytoplasmic events. Hum Reprod Update. 2018;24(3):245–66.CrossRefGoogle ScholarPubMed
Da Broi, MG, Giorgi, VSI, Wang, F, Keefe, DL, Albertini, D, Navarro, PA. Influence of follicular fluid and cumulus cells on oocyte quality: clinical implications. J Assist Reprod Genet. 2018;35(5):735–51.CrossRefGoogle ScholarPubMed
Latham, KE. Stress signaling in mammalian oocytes and embryos: a basis for intervention and improvement of outcomes. Cell Tissue Res. 2016;363(1):159–67.Google Scholar
Combelles, CMH, Rawe, VY. Determinants of oocyte quality: impact on in vitro fertilization failures. In: Coticchio, G, Albertini, DF, De Santis, L, editors. Oogenesis. New York: Springer; 2013. p. 307–27.Google Scholar
Combelles, CM, Kearns, WG, Fox, JH, Racowsky, C. Cellular and genetic analysis of oocytes and embryos in a human case of spontaneous oocyte activation. Hum Reprod. 2011;26(3):545–52.Google Scholar
Dal Canto, M, Guglielmo, MC, Mignini Renzini, M, Fadini, R, Moutier, C, Merola, M, et al. Dysmorphic patterns are associated with cytoskeletal alterations in human oocytes. Hum Reprod. 2017;32(4):750–7.Google ScholarPubMed
McGinnis, LK, Albertini, DF. Dynamics of protein phosphorylation during meiotic maturation. J Assist Reprod Genet. 2010;27(4):169–82.Google Scholar
Bebbere, D, Masala, L, Albertini, DF, Ledda, S. The subcortical maternal complex: multiple functions for one biological structure? J Assist Reprod Genet. 2016;33(11):1431–8.Google Scholar
Feng, R, Yan, Z, Li, B, Yu, M, Sang, Q, Tian, G, et al. Mutations in TUBB8 cause a multiplicity of phenotypes in human oocytes and early embryos. J Med Genet. 2016;53(10):662–71.CrossRefGoogle Scholar
Andersen, CY, Kelsey, T, Mamsen, LS, Vuong, LN. Shortcomings of an unphysiological triggering of oocyte maturation using human chorionic gonadotropin. Fertil Steril. 2020;114(2):200–8.CrossRefGoogle ScholarPubMed
Zaninovic, N, Nohales, M, Zhan, Q, de Los Santos, ZMJ, Sierra, J, Rosenwaks, Z, et al. A comparison of morphokinetic markers predicting blastocyst formation and implantation potential from two large clinical data sets. J Assist Reprod Genet. 2019;36(4):637–46.CrossRefGoogle ScholarPubMed
Simopoulou, M, Sfakianoudis, K, Maziotis, E, Antoniou, N, Rapani, A, Anifandis, G, et al. Are computational applications the “crystal ball” in the IVF laboratory? The evolution from mathematics to artificial intelligence. J Assist Reprod Genet. 2018;35(9):1545–57.Google Scholar
Maziotis, E, Sfakianoudis, K, Giannelou, P, Grigoriadis, S, Rapani, A, Tsioulou, P, et al. Evaluating the value of day 0 of an ICSI cycle on indicating laboratory outcome. Sci Rep. 2020;10(1):19325.CrossRefGoogle Scholar
Vuong, LN, Le, AH, Ho, VNA, Pham, TD, Sanchez, F, Romero, S, et al. Live births after oocyte in vitro maturation with a prematuration step in women with polycystic ovary syndrome. J Assist Reprod Genet. 2020;37(2):347–57.CrossRefGoogle ScholarPubMed

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