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Chapter 12 - The Use of Botulinum Neurotoxin in Otorhinolaryngology

Published online by Cambridge University Press:  02 November 2023

By
Rainer Laskawi ,
Arno Olthoff  and
Oleg Olegovich Ivanov
Edited by
Daniel Truong ,
Dirk Dressler ,
Mark Hallett ,
Christopher Zachary  and
Mayank Pathak
Daniel Truong
Affiliation:
University of California, Riverside
Dirk Dressler
Affiliation:
Hannover Medical School
Mark Hallett
Affiliation:
National Institutes of Health (NIH)
Christopher Zachary
Affiliation:
University of California, Irvine
Mayank Pathak
Affiliation:
Truong Neuroscience Institute
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Summary

Various disorders affecting the ears, nose and throat (ENT) are suited for treatment with botulinum neurotoxin (BoNT). This chapter focuses on the following disorders, describing symptomatology, application of BoNT injections, and dosing ranges: laryngeal dystonia, palatal tremor, dysphagia, hypersalivation (sialorrhea), gustatory sweating (Frey’s syndrome), rhinorrhea, hyperlacrimation and speech problems.

Keywords

Botulinum neurotoxinBoNTlaryngeal dystoniapalatal tremordysphagiahypersalivation (sialorrhea)gustatory sweating (Frey’s syndrome)rhinorrheahyperlacrimation
Type
Chapter
Information
Manual of Botulinum Toxin Therapy , pp. 89 - 99
Publisher: Cambridge University Press
Print publication year: 2023

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References

Chao, SS, Graham, SM, Hoffman, HT (2004). Management of pharyngoesophageal spasm with Botox. Otolaryngol Clin North Am, 37, 559–66.Google Scholar
Ellies, M, Gottstein, U, Rohrbach-Volland, S, Arglebe, C, Laskawi, R (2004). Reduction of salivary flow with botulinum toxin: extended report on 33 patients with drooling, salivary fistulas, and sialadenitis. Laryngoscope, 114, 1856–60.Google Scholar
Jost, WH, Friedman, A, Michel, O, et al. (2019). SIAXI: placebo-controlled, randomized, double-blind study of incobotulinumtoxA for sialorrhea. Neurology, 92, e1982–e91.CrossRefGoogle ScholarPubMed
Laskawi, R, Rohrbach, S (2002). Frey’s syndrome: treatment with botulinum toxin. In Kreyden, OP, Böni, R, Burg, G (eds.) Hyperhidrosis and Botulinum Toxin in Dermatology. Basel: Karger, pp. 170–7.Google Scholar
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Olthoff, A, Laskawi, R, Kruse, E (2007). Successful treatment of autophonia with botulinum toxin: case report. Ann Otol Rhinol Laryngol, 116, 594–8.Google Scholar
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Whittaker, KW, Matthews, BN, Fitt, AW, Sandramouli, S (2003). The use of botulinum toxin A in the treatment of functional epiphora. Orbit, 22, 193–8.Google Scholar

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