Skip to main content Accessibility help

We use cookies to distinguish you from other users and to provide you with a better experience on our websites. Close this message to accept cookies or find out how to manage your cookie settings.

Close cookie message
×
Hostname: page-component-669899f699-chc8l Total loading time: 0 Render date: 2025-05-01T05:10:14.493Z Has data issue: false hasContentIssue false

Chapter 3 - The Ovarian Reserve

Predicting the Menopause

Published online by Cambridge University Press:  18 June 2020

By
Richard A. Anderson
Edited by
Nicholas Panay ,
Paula Briggs  and
Gabor T. Kovacs
Nicholas Panay
Affiliation:
Queen Charlotte's & Chelsea Hospital, London
Paula Briggs
Affiliation:
Liverpool Women's NHS Foundation Trust
Gabor T. Kovacs
Affiliation:
Monash University, Victoria
Get access

Summary

The essential cause of the existence of the menopause is that the ovary contains a finite number of follicles: these are progressively lost with time until insufficient remain to support menstrual cyclicity. Ovarian follicles are both the source of the female gamete, and the key site of reproductive hormone production. Depletion of follicle numbers therefore results in both loss of fertility and gonadal estrogen production, and thus differs substantially from the situation in the male where the two functions of the gonad are anatomically and functionally more independent, and loss of one does not necessitate loss of the other.

Type
Chapter
Information
Managing the Menopause , pp. 19 - 27
Publisher: Cambridge University Press
Print publication year: 2020

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

Book purchase

Temporarily unavailable

References

Wallace, WH, Kelsey, TW. Human ovarian reserve from conception to the menopause. PLoS ONE 2010;5:e8772.Google Scholar
Broekmans, FJ, Soules, MR, Fauser, BC. Ovarian aging: mechanisms and clinical consequences. Endocr Rev 2009;30:465–93.CrossRefGoogle ScholarPubMed
Dewailly, D, Andersen, CY, Balen, A, et al. The physiology and clinical utility of anti-Mullerian hormone in women. Hum Reprod Update 2014;20:370–85.Google Scholar
Freeman, EW, Sammel, MD, Lin, H, et al. Anti-Mullerian hormone as a predictor of time to menopause in late reproductive age women. J Clin Endocrinol Metab 2012;97:1673–80.CrossRefGoogle ScholarPubMed
Tehrani, FR, Solaymani-Dodaran, M, Tohidi, M, et al. Modeling age at menopause using serum concentration of anti-Mullerian hormone. J Clin Endocrinol Metab 2013;98:729–35.CrossRefGoogle ScholarPubMed
de Kat, AC, van der Schouw, YT, Eijkemans, MJC, et al. Can menopause prediction be improved with multiple AMH measurement? Results for the prospective Doetinchem Cohort Study. J Clin Endo Metab 2019; doi 10.21210/jc.2018-02607.Google Scholar
Anderson, RA, Mansi, J, Coleman, RE, Adamson, DJA, Leonard, RCF. The utility of anti-Mullerian hormone in the diagnosis and prediction of loss of ovarian function following chemotherapy for early breast cancer. Eur J Cancer 2017;87:58–64.CrossRefGoogle ScholarPubMed
Anderson, RA, Remedios, R, Kirkwood, AA, et al. Determinants of ovarian function after response-adapted therapy in patients with advanced Hodgkin’s lymphoma (RATHL): a secondary analysis of a randomised phase 3 trial. Lancet Oncol 2018;19:1328–1337.Google Scholar
Anderson, RA, Rosendahl, M, Kelsey, TW, et al. Pretreatment anti-Mullerian hormone predicts for loss of ovarian function after chemotherapy for early breast cancer. Eur J Cancer 2013;49:3404–11.CrossRefGoogle ScholarPubMed
Kelsey, TW, Wright, P, Nelson, SM, et al. A validated model of serum anti-Müllerian hormone from conception to menopause. PLoS ONE 2011;6:e22024.Google Scholar
Brougham, MF, Crofton, PM, Johnson, EJ, et al. Anti-Mullerian hormone is a marker of gonadotoxicity in pre- and postpubertal girls treated for cancer: a prospective study. J Clin Endocrinol Metab 2012;97:2059–67.CrossRefGoogle ScholarPubMed
Argyle, CE, Harper, JC, Davies, MC. Oocyte cryopreservation: where are we now? Hum Reprod Update 2016;22:440–9.CrossRefGoogle ScholarPubMed
Cobo, A, García-Velasco, J, Domingo, J, Pellicer, A, Remohí, J. Elective and onco-fertility preservation: factors related to IVF outcomes. Hum Reprod 2018;33:2222–31.Google Scholar

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×