Skip to main content Accessibility help
×
Hostname: page-component-78c5997874-s2hrs Total loading time: 0 Render date: 2024-11-09T06:19:28.323Z Has data issue: false hasContentIssue false

Chapter 15 - Management of Twin-Reversed Arterial Perfusion (TRAP) Sequence

Published online by Cambridge University Press:  11 October 2022

Leanne Bricker
Affiliation:
Corniche Hospital, Abu Dhabi
Julian N. Robinson
Affiliation:
Brigham & Women's Hospital, Boston
Baskaran Thilaganathan
Affiliation:
St George's Hospital Medical School, University of London
Get access

Summary

Twin reversed arterial perfusion sequence (TRAP) is a rare complication of monochorionic twins consisting of complete retrograde blood perfusion with consequent developmental disruption and malformation of one twin (acardiac twin), blood bypass of the placenta and subsequent hemodynamic overload in the otherwise normally developed twin (pump twin). Recent studies have identified a higher incidence than historically reported and identification in early pregnancy is crucial to establish opportune diagnosis and management. If not detected, the survival rate of the pump twin is only 50 – 60%, as heart failure, fetal hydrops and intrauterine death may develop, as well as miscarriage or preterm delivery may occur. As a result of increasing awareness and early diagnosis, treatment options have shifted from the second to the first trimester in recent years, although optimal timing and mode of intervention is still controversial. In this chapter the incidence, pathophysiology and clinical presentation of TRAP sequence will be discussed, as well as different therapeutic options will be addressed.

Type
Chapter
Information
Management of Multiple Pregnancies
A Practical Guide
, pp. 157 - 167
Publisher: Cambridge University Press
Print publication year: 2022

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Van Gemert, MJ, Van den Wijngaard, JP, Vandenbussche, FP. Twin reversed arterial perfusion sequence is more frequent than generally accepted. Birth Defects Res A Clin Mol Teratol 2015;103(7):641–3.CrossRefGoogle Scholar
Benirschke, K. The monozygotic twinning process, the twin–twin transfusion syndrome and acardiac twins. Placenta 2009;30(11):923–8.CrossRefGoogle ScholarPubMed
Machin, G. Non-identical monozygotic twins, intermediate twin types, zygosity testing, and the non-random nature of monozygotic twinning: s review. Am J Med Genet Part C Semin Med Genet 2009;151C:110–27.Google Scholar
Lewi, L, Valencia, C, Gonzalez, E, et al. The outcome of twin reversed arterial perfusion sequence diagnosed in the first trimester. Am J Obstet Gynecol 2010;203:213.e1e4.CrossRefGoogle ScholarPubMed
Chaveeva, P, Poon, LC, Sotiriadis, A, Kosinski, P, Nicolaides, KH. Optimal method and timing of intrauterine intervention in twin reversed arterial perfusion sequence: case study and meta-analysis. Fetal Diagn Ther 2014;35:267–79.CrossRefGoogle ScholarPubMed
TRAP Intervention STudy (TRAPIST). ClinincalTrials.gov: NCT02621645.Google Scholar
Jelin, E, Hirose, S, Rand, L et al. Perinatal outcome of conservative management versus fetal intervention for twin reversed arterial perfusion sequence with a small acardiac twin. Fetal Diagn Ther 2010;27:138–41.CrossRefGoogle ScholarPubMed
Berg, C, Koenninger, A, Gembruch, U, Geipel, A. Twin arterial reversed arterial perfusion (TRAP) sequence: does monoamnionicity preclude early intervention? Ultrasound Obstet Gynecol 2014;44:241–2.CrossRefGoogle Scholar
Valsky, DV, Martinez-Serrano, MJ, Sanz, M et al. Cord occlusion followed by laser cord transection in monochorionic monoamniotic discordant twins. Ultrasound Obstet Gynecol 2011;37:684–8.CrossRefGoogle ScholarPubMed
Tavares de Sousa, M, Glosemeyer, P, Diemert, A, Bamberg, C, Hecher, K. First-trimester intervention in twin reversed arterial perfusion sequence. Ultrasound Obstet Gynecol 2020;55:47–9.CrossRefGoogle ScholarPubMed
Berg, C, Holst, D, Mallmann, MR, Gottschalk, I, Gembruch, U, Geipel, A. Early vs late intervention in twin reversed arterial perfusion sequence. Ultrasound Obstet Gynecol 2014;43:60–4.CrossRefGoogle ScholarPubMed
Vitucci, A, Fichera, A, Fratelli, N, Sartori, E, Prefumo, F. Twin reversed arterial perfusion sequence: current treatment options. Int J Womens Health 2020;12:435–43.CrossRefGoogle ScholarPubMed
Lee, H, Bebbington, M, Crombelholme, TM, North American Fetal Therapy Network. The North American Fetal Therapy Network Registry data on outcomes of radiofrequency ablation for twin-reversed arterial perfusion sequence. Fetal Diagn Ther 2013;33(4):224–9.CrossRefGoogle Scholar
Diehl, W, Hecher, K. Selective cord coagulation in acardiac twins. Semin Fetal Neonatal Med 2007;12(6):458–63.CrossRefGoogle ScholarPubMed
Pagani, G, D’Antonio, F, Khalil, A, Papageorghiou, A, Bhide, A, Thilaganathan, B. Intrafetal laser treatment for twin reversed arterial perfusion sequence: cohort study and meta-analysis. Ultrasound Obstet Gynecol 2013 Jul;42(1):614. https://doi.org/10.1002/uog.12495CrossRefGoogle ScholarPubMed

Save book to Kindle

To save this book to your Kindle, first ensure [email protected] is added to your Approved Personal Document E-mail List under your Personal Document Settings on the Manage Your Content and Devices page of your Amazon account. Then enter the ‘name’ part of your Kindle email address below. Find out more about saving to your Kindle.

Note you can select to save to either the @free.kindle.com or @kindle.com variations. ‘@free.kindle.com’ emails are free but can only be saved to your device when it is connected to wi-fi. ‘@kindle.com’ emails can be delivered even when you are not connected to wi-fi, but note that service fees apply.

Find out more about the Kindle Personal Document Service.

Available formats
×

Save book to Dropbox

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Dropbox.

Available formats
×

Save book to Google Drive

To save content items to your account, please confirm that you agree to abide by our usage policies. If this is the first time you use this feature, you will be asked to authorise Cambridge Core to connect with your account. Find out more about saving content to Google Drive.

Available formats
×