Book contents
- Frontmatter
- Contents
- Preface
- Acknowledgments
- List of abbreviations
- 1 Bringing muscles into focus; the first two millennia
- 2 Muscle metabolism after the Chemical Revolution; lactic acid takes the stage
- 3 The relationship between mechanical events, heat production and metabolism; studies between 1840 and 1930
- 4 The influence of brewing science on the study of muscle glycolysis; adenylic acid and the ammonia controversy
- 5 The discovery of phosphagen and adenosinetriphosphate; contraction without lactic acid
- 6 Adenosinetriphosphate as fuel and as phosphate-carrier
- 7 Early studies of muscle structure and theories of contraction, 1870–1939
- 8 Interaction of actomyosin and ATP
- 9 Some theories of contraction mechanism, 1939 to 1956
- 10 On myosin, actin and tropomyosin
- 11 The sliding mechanism
- 12 How does the sliding mechanism work?
- 13 Excitation, excitation-contraction coupling and relaxation
- 14 Happenings in intact muscle: the challenge of adenosinetriphosphate breakdown
- 15 Rigor and the chemical changes responsible for its onset
- 16 Respiration
- 17 Oxidative phosphorylation
- 18 The regulation of carbohydrate metabolism for energy supply to the muscle machine
- 19 A comparative study of the striated muscle of vertebrates
- 20 Enzymic and other effects of denervation, cross-innervation and repeated stimulation
- 21 Some aspects of muscle disease
- 22 Contraction in muscles of invertebrates
- 23 Vertebrate smooth muscle
- 24 Energy provision and contractile proteins in non-muscular functions
- The perspective surveyed
- References
- Author index
- Subject index
1 - Bringing muscles into focus; the first two millennia
Published online by Cambridge University Press: 04 August 2010
- Frontmatter
- Contents
- Preface
- Acknowledgments
- List of abbreviations
- 1 Bringing muscles into focus; the first two millennia
- 2 Muscle metabolism after the Chemical Revolution; lactic acid takes the stage
- 3 The relationship between mechanical events, heat production and metabolism; studies between 1840 and 1930
- 4 The influence of brewing science on the study of muscle glycolysis; adenylic acid and the ammonia controversy
- 5 The discovery of phosphagen and adenosinetriphosphate; contraction without lactic acid
- 6 Adenosinetriphosphate as fuel and as phosphate-carrier
- 7 Early studies of muscle structure and theories of contraction, 1870–1939
- 8 Interaction of actomyosin and ATP
- 9 Some theories of contraction mechanism, 1939 to 1956
- 10 On myosin, actin and tropomyosin
- 11 The sliding mechanism
- 12 How does the sliding mechanism work?
- 13 Excitation, excitation-contraction coupling and relaxation
- 14 Happenings in intact muscle: the challenge of adenosinetriphosphate breakdown
- 15 Rigor and the chemical changes responsible for its onset
- 16 Respiration
- 17 Oxidative phosphorylation
- 18 The regulation of carbohydrate metabolism for energy supply to the muscle machine
- 19 A comparative study of the striated muscle of vertebrates
- 20 Enzymic and other effects of denervation, cross-innervation and repeated stimulation
- 21 Some aspects of muscle disease
- 22 Contraction in muscles of invertebrates
- 23 Vertebrate smooth muscle
- 24 Energy provision and contractile proteins in non-muscular functions
- The perspective surveyed
- References
- Author index
- Subject index
Summary
ANTIQUITY AND THE HELLENISTIC AGE
In the development of thought about the bodies of men and animals there came a time when the age-old acceptance of undifferentiated body-substance, the biblical ‘flesh of rams’ or the meat on which Homeric heroes feasted, gave place to a realisation that it consisted of individual muscles. How early did this happen and when was the function of these muscles as instruments of movement realised? With these questions our story naturally begins.
The Hippocratic collection of writings on medicine and its philosophy, by a number of writers of his school as well as perhaps by Hippocrates of Cos himself, was put together before the end of the third century B.C. and includes works of the two previous centuries, some indeed containing ideas from still earlier times. There is thus no such thing as a single system of thought to be found in them; the different treatises of the Corpus, some sixty in number all told, represent several different, and even opposing, schools. Three of them have been attributed by some distinguished scholars to the great physician of Cos himself, and eight more are considered to date from his time (460 to 380 B.C.). The only certainly pre-Hippocratic one is the ‘Sevens’, a prognostic text which implies the humoral theory of disease and the doctrine of critical days.
In these Greek writings the tendons (which were confused with nerves) were endowed with the power of causing movement. In fact the same word neuron was used indiscriminately for both, just as phlebes was used indifferently for the veins and the arteries.
- Type
- Chapter
- Information
- Machina CarnisThe Biochemistry of Muscular Contraction in its Historical Development, pp. 1 - 26Publisher: Cambridge University PressPrint publication year: 1971