Book contents
- Frontmatter
- Contents
- List of contributors
- Preface
- Part I LYMPHOMA OVERVIEW
- Part II LYMPHOMA SUBTYPES
- 7 Hodgkin's lymphoma
- 8 Follicular lymphoma
- 9 MALT lymphoma and other marginal zone lymphomas
- 10 Small lymphocytic lymphoma and its variants
- 11 Mantle cell lymphoma
- 12 Diffuse large B-cell lymphoma
- 13 Burkitt's and lymphoblastic lymphomas
- 14 Central nervous system lymphoma
- 15 T-cell lymphoma
- 16 Cutaneous lymphoma
- 17 Lymphoma in the immunosuppressed
- Index
- References
12 - Diffuse large B-cell lymphoma
from Part II - LYMPHOMA SUBTYPES
Published online by Cambridge University Press: 05 March 2010
- Frontmatter
- Contents
- List of contributors
- Preface
- Part I LYMPHOMA OVERVIEW
- Part II LYMPHOMA SUBTYPES
- 7 Hodgkin's lymphoma
- 8 Follicular lymphoma
- 9 MALT lymphoma and other marginal zone lymphomas
- 10 Small lymphocytic lymphoma and its variants
- 11 Mantle cell lymphoma
- 12 Diffuse large B-cell lymphoma
- 13 Burkitt's and lymphoblastic lymphomas
- 14 Central nervous system lymphoma
- 15 T-cell lymphoma
- 16 Cutaneous lymphoma
- 17 Lymphoma in the immunosuppressed
- Index
- References
Summary
INTRODUCTION
Diffuse large B-cell lymphoma (DLBCL) is the most common type of non-Hodgkin's lymphoma (NHL), accounting for 35–40% of all cases of NHL. Despite high reported response rates to anthracycline-based combination chemotherapy regimens, only 50–65% of patients with this disease have achieved long-term disease-free survival with this approach. The emergence of new strategies, including monoclonal antibodies, dose-dense chemotherapy approaches and the identification of new rational therapeutic targets by gene expression profiling, has resulted in improvements in outcome for patients with this disease in recent years.
Involvement of extranodal sites, either as a primary site of disease or as sites of dissemination, is relatively common in DLBCL. With the exception of primary central nervous system lymphoma (see Chapter 14) and some other specific anatomic sites, treatment recommendations for DLBCL are generally identical for nodal and extranodal disease, with the exception of single-site non-lower limb DLBCL of the skin (see Chapter 16).
CLINICAL PRESENTATION
The clinical presentation of DLBCL, as with other types of NHL, is most commonly with painless lymphadenopathy. Approximately 25% of patients present with anatomically limited stage disease (clinical stage I or II), with the remaining 75% having more advanced disease (bulky stage II, or stage III–IV). Many patients will also experience constitutional (“B”) symptoms including drenching night sweats, unexplained fevers and unexplained weight loss of more than 10% of body weight. Since extranodal disease is relatively common in DLBCL, and since almost any organ can be affected by this disease, presenting symptoms may mimic many other diseases.
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- Information
- Lymphoma: Pathology, Diagnosis and Treatment , pp. 168 - 181Publisher: Cambridge University PressPrint publication year: 2007