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Chapter 10 - Neonatal Hepatitis and Congenital Infections

from Section II - Cholestatic Liver Disease

Published online by Cambridge University Press:  19 January 2021

By
Philip Rosenthal  and
Leina Alrabadi
Edited by
Frederick J. Suchy ,
Ronald J. Sokol  and
William F. Balistreri
Edited in association with
Jorge A. Bezerra ,
Cara L. Mack  and
Benjamin L. Shneider
Frederick J. Suchy
Affiliation:
University of Colorado, Children’s Hospital Colorado, Aurora
Ronald J. Sokol
Affiliation:
University of Colorado, Children’s Hospital Colorado, Aurora
William F. Balistreri
Affiliation:
Cincinnati Children’s Hospital Medical Center, Cincinnati
Jorge A. Bezerra
Affiliation:
Cincinnati Children’s Hospital Medical Center, Cincinnati
Cara L. Mack
Affiliation:
University of Colorado, Children’s Hospital Colorado, Aurora
Benjamin L. Shneider
Affiliation:
Texas Children’s Hospital, Houston
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Summary

Neonatal hepatitis refers to a heterogeneous group of disorders that result in a somewhat similar morphologic change in the liver of an infant younger than three months of age in response to various insults. The term neonatal hepatitis has been used at times to include all causes of cholestasis in infancy in which extrahepatic biliary obstruction is excluded. Although in the majority of cases an etiology cannot be found, specific infectious and metabolic causes have been identified that may present as neonatal hepatitis. At final diagnosis, neonatal hepatitis is responsible for approximately 40% of the cases of infants with cholestasis and is the most frequently encountered liver disorder of early infancy. Males usually predominate over females (2:1). Additionally, some familial cases have been reported, suggesting either a maternal environmental factor or autosomal recessive inheritance.

Type
Chapter
Information
Liver Disease in Children , pp. 147 - 161
Publisher: Cambridge University Press
Print publication year: 2021

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